Recombinant Human CD36 Protein, GST-Tagged

• Cat.No.: CD36-0795H
• Product Overview: Human CD36 full-length ORF (NP_000063.2, 1 a.a. - 472 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 79.5 kDa
• AA Sequence: MGCDRNCGLIAGAVIGAVLAVFGGI LMPVGDLLIQKTIKKQVVLEEGTIA FKNWVKTGTEVYRQFWIFDVQNPQE VMMNSSNIQVKQRGPYTYRVRFLAK ENVTQDAEDNTVSFLQPNGAIFEPS LSVGTEADNFTVLNLAVAAASHIYQ NQFVQMILNSLINKSKSSMFQVRTL RELLWGYRDPFLSLVPYPVTTTVGL FYPYNNTADGVYKVFNGKDNISKVA IIDTYKGKRNLSYWESHCDMINGTD AASFPPFVEKSQVLQFFSSDICRSI YAVFESDVNLKGIPVYRFVLPSKAF ASPVENPDNYCFCTEKIISKNCTSY GVLDISKCKEGRPVYISLPHFLYAS PDVSEPIDGLNPNEEEHRTYLDIEP ITGFTLQFAKRLQVNLLVKPSEKIQ VLKNLKRNYIVPILWLNETGTIGDE KANMFRSQVTGKINLLGLIEMILLS VGVVMFVAFMISYCACRSKTIK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CD36 CD36 molecule (thrombospondin receptor) [ Homo sapiens ]
• Official Symbol: CD36
• Synonyms: CD36; CD36 molecule (thrombospondin receptor); CD36 antigen (collagen type I receptor, thrombospondin receptor); platelet glycoprotein 4; FAT; GP3B; GP4; GPIV; SCARB3; GPIIIB; PAS IV; PAS-4 protein; glycoprotein IIIb; cluster determinant 36; fatty acid translocase; platelet glycoprotein IV; scavenger receptor class B, member 3; leukocyte differentiation antigen CD36; CHDS7; PASIV; BDPLT10
• Gene ID: 948
• mRNA Refseq: NM_000072
• Protein Refseq: NP_000063
• MIM: 173510
• UniProt ID: P16671

Reviews

05/21/2020

Dependable protein purification, consistently high-quality results.

04/10/2019

Great antibody validation, enhances our immunoprecipitation experiments.

12/28/2018

Swift protein expression optimization, invaluable for our research efficiency.

Q&As

What is the impact of CD36 on inflammation and the immune response, particularly in chronic inflammatory diseases?

CD36 is involved in inflammation and immune responses, potentially exacerbating chronic inflammatory conditions.

How do alterations in CD36 expression or activity affect obesity and related health complications?

Variations in CD36 function can influence the risk of obesity and associated health issues like metabolic syndrome.

What are the mechanisms by which CD36 modulates cell signaling and energy homeostasis?

CD36 modulates cell signaling related to energy utilization and storage, impacting metabolic health.

How does CD36 contribute to the pathogenesis of metabolic disorders, such as insulin resistance and type 2 diabetes?

CD36 affects the development of metabolic disorders by influencing lipid metabolism and insulin sensitivity.

How does CD36 influence taste perception, especially in the detection of dietary fats?

CD36 aids in taste perception, particularly in detecting and responding to dietary fats.

What role does CD36 play in the development of cardiovascular diseases like atherosclerosis?

CD36 is implicated in cardiovascular diseases, contributing to the formation of atherosclerotic plaques.

How does CD36 (Cluster of Differentiation 36) function in fatty acid metabolism and uptake?

CD36 facilitates the uptake and metabolism of fatty acids in cells, playing a critical role in lipid processing.