Recombinant Full Length Human CHEK1 Protein, C-Flag-tagged
Cat.No. : | CHEK1-1024HFL |
Product Overview : | Recombinant Full Length Human CHEK1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 54.3 kDa |
AA Sequence : | MAVPFVEDWDLVQTLGEGAYGEVQL AVNRVTEEAVAVKIVDMKRAVDCPE NIKKEICINKMLNHENVVKF YGHRREGNIQYLFLEYCSGGELFDR IEPDIGMPEPDAQRFFHQLMAGVVY LHGIGITHRDIKPENLLLDE RDNLKISDFGLATVFRYNNRERLLN KMCGTLPYVAPELLKRREFHAEPVD VWSCGIVLTAMLAGELPWDQ PSDSCQEYSDWKEKKTYLNPWKKID SAPLALLHKILVENPSARITIPDIK KDRWYNKPLKKGAKRPRVTS GGVSESPSGFSKHIQSNLDFSPVNS ASSEENVKYSSSQPEPRTGLSLWDT SPSYIDKLVQGISFSQPTCP DHMLLNSQLLGTPGSSQNPWQRLVK RMTRFFTKLDADKSYQCLKETCEKL GYQWKKSCMNQVTISTTDRR NNKLIFKVNLLEMDDKILVDFRLSK GDGLEFKRHFLKIKGKLIDIVSSQK VWLPATTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Protein Kinase, Stem cell - Pluripotency |
Protein Pathways : | Cell cycle, p53 signaling pathway |
Gene Name : | CHEK1 checkpoint kinase 1 [ Homo sapiens (human) ] |
Official Symbol : | CHEK1 |
Synonyms : | CHK1 |
Gene ID : | 1111 |
mRNA Refseq : | NM_001114122.3 |
Protein Refseq : | NP_001107594.1 |
MIM : | 603078 |
UniProt ID : | O14757 |
Products Types
◆ Recombinant Protein | ||
CHEK1-1026R | Recombinant Rat CHEK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
CHEK1-1221H | Recombinant Human CHEK1 Protein, GST-Tagged | +Inquiry |
CHEK1-3217H | Recombinant Human CHEK1 Protein, MYC/DDK-tagged | +Inquiry |
CHEK1-1186H | Recombinant Human CHEK1 Protein (A2-T476), Tag Free | +Inquiry |
CHEK1-1220H | Active Recombinant Human CHEK1 Protein, GST-His-Tagged | +Inquiry |
◆ Lysates | ||
CHEK1-438HCL | Recombinant Human CHEK1 cell lysate | +Inquiry |
CHEK1-001MCL | Recombinant Mouse CHEK1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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