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Recombinant Human CHEK1 Protein, GST-Tagged

Cat.No. : CHEK1-1221H
Product Overview : Human CHEK1 full-length ORF (AAH04202, 1 a.a. - 476 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 77.88 kDa
AA Sequence : MAVPFVEDWDLVQTLGEGAYGEVQL AVNRVTEEAVAVKIVDMKRAVDCPE NIKKEICINKMLNHENVVKFYGHRR EGNIQYLFLEYCSGGELFDRIEPDI GMPEPDAQRFFHQLMAGVVYLHGIG ITHRDIKPENLLLDERDNLKISDFG LATVFRYNNRERLLNKMCGTLPYVA PELLKRREFHAEPVDVWSCGIVLTA MLAGELPWDQPSDSCQEYSDWKEKK TYLNPWKKIDSAPLALLHKILVENP SARITIPDIKKDRWYNKPLKKGAKR PRVTSGGVSESPSGFSKHIQSNLDF SPVNSASSEENVKYSSSQPEPRTGL SLWDTSPSYIDKLVQGISFSQPTCP DHMLLNSQLLGTPGSSQNPWQRLVK RMTRFFTKLDADKPYQCLKETREKL GYQWKKSCMNQVTISTTDRRNNKLI FKVNLLEMDDKILVDFRLSKGDGLE FKRHFLKIKGKLIDIVSSQKVWLPA T
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CHEK1 checkpoint kinase 1 [ Homo sapiens ]
Official Symbol : CHEK1
Synonyms : CHEK1; checkpoint kinase 1; CHK1 (checkpoint, S.pombe) homolog, CHK1 checkpoint homolog (S. pombe); serine/threonine-protein kinase Chk1; CHK1; Chk1-S; checkpoint kinase-1; CHK1 checkpoint homolog; cell cycle checkpoint kinase; Checkpoint, S. pombe, homolog of, 1;
Gene ID : 1111
mRNA Refseq : NM_001114121
Protein Refseq : NP_001107593
MIM : 603078
UniProt ID : O14757

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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