CTNNB1

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CTNNB1

Official Full Name catenin (cadherin-associated protein), beta 1, 88kDa
Background The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]
Synonyms CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa; CTNNB; MRD19; armadillo; catenin beta-1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • Baculovirus-Insect Cells
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • DDK
    • GST
    • His
    • His/GST
    • MYC/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CTNNB1-10H Recombinant Human CTNNB1 Protein, His-tagged Insect Cell His
    Human CTNNB1-1174H Recombinant Human CTNNB1 Protein (2-781 aa), GST-tagged E.coli GST
    Human CTNNB1-1327H Recombinant Human CTNNB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CTNNB1-1441H Recombinant Human CTNNB1,GST-tagged Sf9 Insect Cell GST
    Human CTNNB1-192H Recombinant Human CTNNB1 protein, His-tagged Insect Cell His
    Human CTNNB1-2082H Recombinant Human CTNNB1 Protein, GST-tagged Wheat Germ GST
    Human CTNNB1-2514H Recombinant Human CTNNB1 Protein (2-781 aa), His-tagged Yeast His
    Human CTNNB1-26623TH Recombinant Human CTNNB1, GST-tagged GST
    Human CTNNB1-3375H Recombinant Human CTNNB1 Protein, DDK-tagged Insect Cell DDK
    Human CTNNB1-3376H Recombinant Human CTNNB1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CTNNB1-3378H Recombinant Human CTNNB1 Protein, His-tagged Insect Cell His
    Human CTNNB1-36H Recombinant Human CTNNB1 protein, His/GST-tagged Baculovirus-Insect Cells His/GST
    Human CTNNB1-3891H Recombinant Human CTNNB1, His & GST tagged Insect Cell His/GST
    Human CTNNB1-4958H Recombinant Human CTNNB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CTNNB1-563HCL Recombinant Human CTNNB1 cell lysate Insect Cell N/A
    Human CTNNB1-5747H Recombinant Human CTNNB1 protein, His-tagged E.coli His
    Mouse CTNNB1-001MCL Recombinant Mouse CTNNB1 cell lysate Insect Cell N/A
    Mouse Ctnnb1-5748M Recombinant Mouse Ctnnb1 protein, His-tagged E.coli His
    Mouse Ctnnb1-7398M Recombinant Mouse Ctnnb1, His & GST tagged Insect Cell His/GST
    Mouse Ctnnb1-779M Recombinant Mouse Ctnnb1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CTNNB1-1657R Recombinant Rat CTNNB1 Protein Mammalian Cell His
    Rat Ctnnb1-5749R Recombinant Rat Ctnnb1 protein, His-tagged E.coli His
    Rhesus Macaque CTNNB1-1080R Recombinant Rhesus monkey CTNNB1 Protein, His-tagged Mammalian Cell His
    Chicken CTNNB1-6638C Recombinant Chicken CTNNB1 Mammalian Cell His
    Zebrafish CTNNB1-8687Z Recombinant Zebrafish CTNNB1 Mammalian Cell His

    CTNNB1 involved in several pathways and played different roles in them. We selected most pathways CTNNB1 participated on our site, such as Adherens junction, Adherens junctions interactions, Adipogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTNNB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adherens junction PTPRB; BAIAP2A; PVRL2; EP300; WASF1; EGFRA; ACTB1; RHOA; INSRB; NLK1
    Adherens junctions interactions JUP; CDH7; CDH6; CDH12; CDH18; ANG; CADM2A; CDH4; CDH10A; CTNNA1
    Adipogenesis CREB1; MBNL1; HMGA1-RS1; AHR; GDF10; CNTFR; E2F1; AGPAT2; MIXL1; GATA2A
    Androgen receptor signaling pathway RNF6; RAD9A; HMGB2A; TGFB1I1; STUB1; RHOB; NR0B2A; KAT7; RUNX2A; SVILA
    Apoptosis CDK5RAP2; CASP3B; IRF1B; IRF4A; DBNL; CASP6L2; IRAK3; MYC; RIPK1; PRKAR2AA
    Apoptotic cleavage of cell adhesion proteins CTNNB2; OCLN; DSG2; PTBP3; DSP; DSG3; CTNNB1; DSG1; PKP1
    Apoptotic cleavage of cellular proteins OCLN; CLSPN; CTNNB2; DSP; GAS2; BCAP31; SPNA2; STK24; DBNLB; DSG1
    Apoptotic execution phase CASP6L1; CLSPN; SATB1; CASP8L1; HIST1H1E; DNM1L; HIST1H1D; SPNA2; STK24; HIST1H1B

    CTNNB1 has several biochemical functions, for example, I-SMAD binding, R-SMAD binding, RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTNNB1 itself. We selected most functions CTNNB1 had, and list some proteins which have the same functions with CTNNB1. You can find most of the proteins on our site.

    Function Related Protein
    I-SMAD binding TGFBR1; SMAD4; SMAD2; SMAD6; AXIN1; SMAD1; SMAD7; AXIN2; CTNNB1; SMURF1
    R-SMAD binding SMAD3; C18orf1; AXIN1; ZC3H3; MEN1; JUN; ZEB2; RANBP3; FOS; SMAD2
    RNA polymerase II activating transcription factor binding EOMES; ATF2; TBX3; MAD2L2; IFI27; LDB1; SETD3; EP300; BEX1; ISL1
    SMAD binding SOD3; BMPR1A; SMURF2; EP300; HMGA2; PRDM16; COL1A2; BMP2; SKOR1B; PURB
    alpha-catenin binding VCL; PKP3; AJUBA; JUPA; JUB; JUP; CTNNB1; CDH2; PKP2; NUMB
    androgen receptor binding PIAS2; BRCA1; EP300; NRIP1; FHL2; RNF6; KDM3A; DDX5; PRMT2; FOXH1
    cadherin binding MMP24; CD46; CTNNA3; CTNNB1; PSEN1; AKAP5; CTNNA1; FER; CTNNA2; JUPA
    double-stranded DNA binding GATA1A; SMAD2; RAD51; HLF; PIN4; IFI203; KLF6; DDX58; MTERF; MTERFD3
    enzyme binding HSPA6; APOA5; CAD; TSPAN33; U2AF2; PRKCE; DDC; HIST1H2AN; IQCB1; TSPAN14
    estrogen receptor binding PRMT2; PPID; PPARG; TMEM38A; CCDC62; DDX17; NCOA1; MMS19; DDX54; ARRB1
    euchromatin binding ASH2L; CTNNB1
    ion channel binding SNTA1; TCAP; KCNIP1; KCNC1; FHL1; ACTN1; RANGRF; YWHAQ; ASPH; FYN
    kinase binding HPCA; CDC6; HSP90AB1; WWC3; TRIP6; PRPSAP1; PFKM; SNAI1; STRADA; JAKMIP3
    nuclear hormone receptor binding NRIP1; HIF1A; CRY1; NCOR1; NCOA1; TACC2; SNW1; MYOD1; CRX; SMARCD3
    protein C-terminus binding TERF2; RBFOX1; YAP1; KPNA3; GRIP1; CALCOCO1; CTBP1; NIPBL; HAND2; BCL10
    protein binding RAB25; FAM19A4; ROPN1; F2RL1; EXOSC8; SIK3; GLP1R; ACACB; PPP2CB; ZC3H10
    protein phosphatase binding SNX3; GNB2L1; SHOC2; CSF1R; LCK; ITGA1; DLG4; VCAN; PIK3R2; CDKN1B
    repressing transcription factor binding TCF3; HDAC9; DDX20; KAT5; ARNTL; CTNNB1; PRDM5; HHEX; HDAC4; GMNN
    signal transducer activity OLFCG1; RRH; OLFCG3; VALOPA; NPY8BR; LSP1; MRGPRA8; CD40; MRGPRA7; OPN1LW1
    transcription coactivator activity GRIP1; CARM1; SUB1; ESR2; CALCOCO1; MMS19; CEBPA; TRIP4; NACA; TAF7L
    transcription factor activity, sequence-specific DNA binding EGR3; FUBP1; FOXG1A; ZNF12; NR4A2A; FOXS1; EGR2A; NKX3-1; ZNF518A; HNF1BB
    transcription factor binding SRF; GATA3; RNF4; TRERF1; PPARGC1B; DIP2C; MDFIC; TBX5; ESR1; IFI16
    transcription regulatory region DNA binding WNT11; IKZF4; CDK9; ZFP335; NFE2L2; ATF4; BRD7; ARRB1; MSX2; GATA3

    CTNNB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTNNB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTNNB1.

    TCF7L2

    Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
    Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).

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