ctnnb1
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  • Official Full Name
  • catenin (cadherin-associated protein), beta 1, 88kDa
  • Background
  • The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]
  • Synonyms
  • CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa; CTNNB; MRD19; armadillo; catenin beta-1;
Cat.#:CTNNB1-2082HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CTNNB1 Protein, GST-tagged
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Cat.#:CTNNB1-3375HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CTNNB1 Protein, DDK-tagged
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Cat.#:CTNNB1-3376HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTNNB1 Protein, MYC/DDK-tagged
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Cat.#:CTNNB1-3378HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CTNNB1 Protein, His-tagged
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Cat.#:CTNNB1-1441HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CTNNB1,GST-tagged
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Cat.#:CTNNB1-192HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CTNNB1 protein, His-tagged
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Cat.#:CTNNB1-26623THTag:GST
Source (Host):Species:Human
Product nameRecombinant Human CTNNB1, GST-tagged
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Cat.#:CTNNB1-36HTag:His/GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CTNNB1 protein, His/GST-tagged
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Cat.#:CTNNB1-3891HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CTNNB1, His & GST tagged
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Cat.#:CTNNB1-5747HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTNNB1 protein, His-tagged
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Cat.#:Ctnnb1-5748MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ctnnb1 protein, His-tagged
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Cat.#:Ctnnb1-7398MTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Ctnnb1, His & GST tagged
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Cat.#:CTNNB1-1657RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CTNNB1 Protein
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Cat.#:Ctnnb1-5749RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ctnnb1 protein, His-tagged
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Cat.#:CTNNB1-1080RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CTNNB1 Protein, His-tagged
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Cat.#:CTNNB1-6638CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CTNNB1
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Cat.#:CTNNB1-8687ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CTNNB1
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Cat.#:CTNNB1-563HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CTNNB1 cell lysate
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Cat.#:CTNNB1-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse CTNNB1 cell lysate
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Involved Pathway

CTNNB1 involved in several pathways and played different roles in them. We selected most pathways CTNNB1 participated on our site, such as Adherens junction, Adherens junctions interactions, Adipogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTNNB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adherens junction
ACTN2B; SMAD3A; RAC1; RAC1B; PTPRM; ACTN4; WASF3B; WAS; PVRL1B; PVRL4
Adherens junctions interactions
CTNNA1; CDH7; CDH18A; CADM2B; PVRL1A; CDH24; CADM2A; ANG; CDH2; CDH12
Adipogenesis
KLF6A; CDKN1A; AHR; PLIN2; GADD45A; BMP3; FRZB; CISD1; GTF3AA; NR2F1
Androgen receptor signaling pathway
STUB1; EGFR; HMGB2A; KDM1A; CARM1; ETV5A; CCDC102A; JUN; PATZ1; EFCAB6
Apoptosis
CAPN2; CYCSB; HDR; BIRC3; BCL2L1; PRKACB; XIAP; DIABLO; HMGB2; DERL3
Apoptotic cleavage of cell adhesion proteins
DSG1; DSG2; OCLN; DSG3; CTNNB2; PTBP3; PKP1; DSP; CTNNB1
Apoptotic cleavage of cellular proteins
CTNNB1; DSG2; SPNA2; CTNNB2; BCAP31; PLECA; BMX; CASP6L1; GAS2; DSG1
Apoptotic execution phase
HMGB2A; HIST1H1D; BMX; DBNLA; GAS2; OCLN; STK24; HIST1H1B; STK26; HIST1H1A

Protein Function

CTNNB1 has several biochemical functions, for example, I-SMAD binding, R-SMAD binding, RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTNNB1 itself. We selected most functions CTNNB1 had, and list some proteins which have the same functions with CTNNB1. You can find most of the proteins on our site.
Function
Related Protein
Function I-SMAD binding
Related Protein TGFB1I1; SMAD6; TGFBR1; AXIN1; SMAD4; SMURF1; SMAD1; SMAD2; AXIN2; SMAD7
Function R-SMAD binding
Related Protein PAX6; ANKRD1; SMAD6; ZEB2; AXIN1; PPM1A; MYOCD; FOS; JUN; MEN1
Function RNA polymerase II activating transcription factor binding
Related Protein ATF2; CTNNB1; ISL1; EOMES; HNF4A; NHLH2; CREB1; CREBBP; IFI27; SMAD3
Function SMAD binding
Related Protein USP15; ACVRL1; PURB; SKIA; SKOR1B; EP300; DAB2; AXIN1; HMGA2; SMAD2
Function alpha-catenin binding
Related Protein PKP2; JUB; VCL; JUP; CTNNB1; JUPA; CDH24; NUMB; PKP3; AJUBA
Function androgen receptor binding
Related Protein KDM3A; NSD1; CDK7; KAT5; NCOA1; RNF14; PRMT2; PIAS1; PARK7; DAXX
Function cadherin binding
Related Protein CTNNA1; FER; CTNNA2; CTNND1; AKAP5; PSEN1; TRPC4; NUMB; VCL; NDRG1
Function double-stranded DNA binding
Related Protein PYDC3; HMGB2; PRKDC; LSM14A; AIM2; NKX2-8; AKAP8; MTERF; EGFR; HLF
Function enzyme binding
Related Protein SUPT5H; CCDC99; HAND1; UGT1A6B; PUS7; TMBIM6; TOP2A; EIF2AK3; ACAT1; BCL10
Function estrogen receptor binding
Related Protein PCNA; FUS; PPARGC1A; XBP1; LEF1; DDX17; ISL1; TRIP4; NCOA1; ARRB1
Function euchromatin binding
Related Protein CTNNB1; ASH2L
Function ion channel binding
Related Protein ANK2; PANX1; BAK1; NOS1; SLC8A1; NEDD4L; DIAP1; YWHAH; SUMO1; KCNC1
Function kinase binding
Related Protein CDC37; CEBPA; EMP2; WWC2; TNFAIP3; SIT1; TOLLIP; CDC6; WWC3; STX1A
Function nuclear hormone receptor binding
Related Protein SIRT1; CTNNB1; Ankar; TACC2; NCOA2; SNW1; MYOD1; MED1; NCOR1; ACTN4
Function protein C-terminus binding
Related Protein MIF4GD; HPCAL4; MAP3K7; VGLL1; TJP2; ARL6IP5; SNF8; DST; SHANK2; AGO2
Function protein binding
Related Protein APPB; MSH3; NBN; GRIN1; YEATS4; SHKBP1; GABPA; SDPR; DDX19A; IRAK2
Function protein phosphatase binding
Related Protein GNB2L1; MET; HSP90B1; DLG4; SHOC2; CDH2; VRK3; PIK3R2; CTNNB1; VCP
Function repressing transcription factor binding
Related Protein SRI; EIF4E; KAT5; NFYB; HHEX; GMNN; MAGEA2; NOC2L; PRDM5; CTNNB1
Function signal transducer activity
Related Protein CNOT7; GRM6B; PLCH1; OLFR482; MRGPRA8; PLCH2; PROKR1A; RGRA; OLFR958; AKAP13
Function transcription coactivator activity
Related Protein TBPL1; NFE2; PML; KAT6A; MKL1B; MED13; ELF3; ARID1A; SMARCC2; GMEB1
Function transcription factor activity, sequence-specific DNA binding
Related Protein ELK3; FOXI3B; NKX3; NR2F6B; NKX6-2; SOX13; MAX; NFIL3-4; GATA2; TAF4B
Function transcription factor binding
Related Protein PRKDC; HDAC8; SRY; TFDP1; FIGLA; FOXA2; IFI16; ATG7; SIRT1; ESRRB
Function transcription regulatory region DNA binding
Related Protein NKX2; ZNF174; THRA; MESP1; KLF1; ATF3; PAX8; KLF4; NFKB1; SMAD6

Interacting Protein

CTNNB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTNNB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTNNB1.
TCF7L2

CTNNB1 Related Articles

Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
Liszka, L; et al. DUCTAL ADENOCARCINOMA OF THE PANCREAS USUALLY RETAINED SMAD4 AND p53 PROTEIN STATUS AS WELL AS EXPRESSION OF EPITHELIAL-TO-MESENCHYMAL TRANSITION MARKERS AND CELL CYCLE REGULATORS AT THE STAGE OF LIVER METASTASIS. POLISH JOURNAL OF PATHOLOGY 65:100-112(2014).