Recombinant Rat Ctnnb1 protein, His-tagged
Cat.No. : | Ctnnb1-5749R |
Product Overview : | Recombinant Rat Ctnnb1 aa. (Leu409~Asp665 (Accession # Q9WU82)) fused with N-terminal His tag was produced in E. coli cells. |
- Specification
- Gene Information
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Description : | Involved in mediating the interaction between cadherins and the actin cytoskeleton. |
Source : | E. coli |
Species : | Rat |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 29.3kDa |
Protein length : | Leu409~Asp665 (Accession # Q9WU82) |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | >95% |
Characteristic : | The isoelectric point is 6.6. |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | Ctnnb1 catenin beta 1 [ Rattus norvegicus (Norway rat) ] |
Official Symbol : | Ctnnb1 |
Synonyms : | Ctnnb1; catenin beta 1; Catnb; catenin beta-1; beta-catenin; catenin (cadherin associated protein), beta 1, 88kDa |
Gene ID : | 84353 |
mRNA Refseq : | NM_053357.2 |
Protein Refseq : | NP_445809.2 |
UniProt ID : | Q9WU82 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, CTNNB1 is implicated in the development and progression of pancreatic cancer, with its dysregulated activity contributing to tumor growth, invasion, and metastasis.
Mutations in the CTNNB1 gene lead to the stabilization and accumulation of β-catenin, contributing to the development of HCC, making it a potential biomarker for the diagnosis and prognosis of HCC.
Studies have shown that CTNNB1 expression levels can serve as an independent prognostic factor in gastric cancer, with high CTNNB1 expression correlating with poor patient outcomes.
While there are no direct CTNNB1-targeted therapies available, various drugs targeting the Wnt signaling pathway are being developed and tested, which indirectly impact CTNNB1 activity in cancer cells.
High expression levels of CTNNB1 in breast cancer cells have been linked to poor prognosis and shorter overall survival, indicating its potential as a prognostic marker for breast cancer.
Customer Reviews (3)
Write a reviewNot only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.
the CTNNB1 protein offers numerous advantages in trials and research experiments.
This commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.
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