Active Recombinant Full Length Human CTNNB1 Protein, C-Flag-tagged

Cat.No. : CTNNB1-21HFL
Product Overview : Recombinant Full Length Human CTNNB1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
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  • Gene Information
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Description : The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Bio-activity : Pull-down assay
Molecular Mass : 85.3 kDa
AA Sequence : MATQADLMELDMAMEPDRKAAVSHW QQQSYLDSGIHSGATTTAPSLSGKG NPEEEDVDTSQVLYEWEQGF SQSFTQEQVADIDGQYAMTRAQRVR AAMFPETLDEGMQIPSTQFDAAHPT NVQRLAEPSQMLKHAVVNLI NYQDDAELATRAIPELTKLLNDEDQ VVVNKAAVMVHQLSKKEASRHAIMR SPQMVSAIVRTMQNTNDVET ARCTAGTLHNLSHHREGLLAIFKSG GIPALVKMLGSPVDSVLFYAITTLH NLLLHQEGAKMAVRLAGGLQ KMVALLNKTNVKFLAITTDCLQILA YGNQESKLIILASGGPQALVNIMRT YTYEKLLWTTSRVLKVLSVC SSNKPAIVEAGGMQALGLHLTDPSQ RLVQNCLWTLRNLSDAATKQEGMEG LLGTLVQLLGSDDINVVTCA AGILSNLTCNNYKNKMMVCQVGGIE ALVRTVLRAGDREDITEPAICALRH LTSRHQEAEMAQNAVRLHYG LPVVVKLLHPPSHWPLIKATVGLIR NLALCPANHAPLREQGAIPRLVQLL VRAHQDTQRRTSMGGTQQQF VEGVRMEEIVEGCTGALHILARDVH NRIVIRGLNTIPLFVQLLYSPIENI QRVAAGVLCELAQDKEAAEA IEAEGATAPLTELLHSRNEGVATYA AAVLFRMSEDKPQDYKKRLSVELTS SLFRTEPMAWNETADLGLDI GAQGEPLGYRQDDPSYRSFHSGGYG QDALGMDPMMEHEMGGHHPGADYPV DGLPDLGHAQDLMDGLPPGD
SNQLAWFDTDLTRTRPLEQKLISEE DLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
Protein Pathways : Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Focal adhesion, Leukocyte transendothelial migration, Melanogenesis, Pathogenic Escherichia coli infection, Pathways in cancer, Prostate cancer, Thyroid cancer, Tight junction, Wnt signaling pathway
Publication :
Gene Name : CTNNB1 catenin beta 1 [ Homo sapiens (human) ]
Official Symbol : CTNNB1
Synonyms : EVR7; CTNNB; MRD19; NEDSDV; armadillo
Gene ID : 1499
mRNA Refseq : NM_001904.4
Protein Refseq : NP_001895.1
MIM : 116806
UniProt ID : P35222

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is the CTNNB1 protein involved in the progression of pancreatic cancer? 12/20/2022

Yes, CTNNB1 is implicated in the development and progression of pancreatic cancer, with its dysregulated activity contributing to tumor growth, invasion, and metastasis.

How is the CTNNB1 protein associated with hepatocellular carcinoma (HCC)? 09/15/2022

Mutations in the CTNNB1 gene lead to the stabilization and accumulation of β-catenin, contributing to the development of HCC, making it a potential biomarker for the diagnosis and prognosis of HCC.

How is the CTNNB1 protein linked to the prognosis of gastric cancer patients? 05/08/2021

Studies have shown that CTNNB1 expression levels can serve as an independent prognostic factor in gastric cancer, with high CTNNB1 expression correlating with poor patient outcomes.

Are there any targeted therapies specifically aimed at CTNNB1 in cancer treatment? 10/10/2018

While there are no direct CTNNB1-targeted therapies available, various drugs targeting the Wnt signaling pathway are being developed and tested, which indirectly impact CTNNB1 activity in cancer cells.

How is the expression of CTNNB1 in breast cancer cells associated with patient survival? 03/12/2016

High expression levels of CTNNB1 in breast cancer cells have been linked to poor prognosis and shorter overall survival, indicating its potential as a prognostic marker for breast cancer.

Customer Reviews (3)

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Reviews
03/27/2023

    Not only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.

    07/28/2017

      the CTNNB1 protein offers numerous advantages in trials and research experiments.

      06/24/2016

        This commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.

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