Recombinant Cynomolgus CTSD Protein, His-tagged

• Cat.No.: CTSD-429C
• Product Overview: Recombinant Cynomolgus CTSD Protein(NP_001270485.1), fused to His-tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Cynomolgus
• Tag: His
• Form: 0.2 μm sterile filtered PBS buffer.
• Molecular Mass: The predicted molecular mass is 43 kDa, and the actual MW is about 40-50 kDa in SDS-PAGE under reducing conditions.
• AA Sequence: LVRIPLHKFTSIRRTMSEIGGPVED LIAKGPISKYSQAMPAVTEGPIPEV LKNYMDAQYYGEIGIGTPPQCFTVV FDTGSSNLWVPSIHCKLLDIACWLH HKYNSDKSSTYVKNGTSFAIHYGSG SLSGYLSQDTVSVPCKSAPSTAALG GVKVERQVFGEAIKQPGITFIAAKF DGILGMAYPRISVNNVLPVFDNLMQ QKLVDQNIFSFYLNRDPTAQPGGEL MLGGTDSKYYRGSLSYLNVTRKAYW QVRLDQVEVASGLTLCKEGCEAIVD TGTSLMVGPVDEVRELQKAIGAVPL IQGEYMIPCEKVSTLPTITLKLGGK GYKLSPEDYTLKVSQAGKTLCLSGF MGMDIPPPSGPLWILGDVFIGRYYT VFDRDNNRVGFAEAARLHHHHHH
• Endotoxin: <1.0 EU per mg of the protein by the LAL method
• Purity: ≥ 95%, by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.83 mg/ml

Gene Information

• Gene Name: CTSD cathepsin D [ Macaca fascicularis (crab-eating macaque) ]
• Official Symbol: CTSD
• Synonyms: CTSD
• Gene ID: 102125635
• mRNA Refseq: NM_001283556.1
• Protein Refseq: NP_001270485.1

Reviews

07/12/2021

Good at western-blot experiments.

03/28/2021

In experiments, the biocompatibility performed well.

03/02/2021

The experimental conditions are broad, and the experimental results are accurate and repeatable.

Q&As

What is the relationship between CTSD proteins and cognitive function?

There is an association between CTSD proteins and cognitive function. In some neurodegenerative diseases, abnormal accumulation and deposition of CTSD proteins may affect neuronal signaling and synaptic function, leading to a decline in cognitive function.

What is the relationship between changes in CTSD protein levels and disease?

In some neurodegenerative diseases, levels of the CTSD protein may change. For example, people with Alzheimer's disease may have elevated levels of the CTSD protein. These changes may help in the diagnosis of the disease and in the assessment of the course of the disease.

For people with cognitive decline, how do you assess their CTSD protein levels?

For people with cognitive decline, their CTSD protein levels can be assessed by a blood or cerebrospinal fluid sample. This evaluation can help doctors understand whether the cause of cognitive decline is related to a neurodegenerative disease.

How can treatment be used to alter the level or function of the CTSD protein?

It is currently no treatment that directly targets the CTSD protein. However, some medications can reduce symptoms of neurodegenerative diseases, such as cholinesterase inhibitors such as donepezil, which can increase acetylcholine levels in synapses, which can improve cognitive function.

Is CTSD protein involved in Parkinson's disease?

People with Parkinson's disease may have reduced levels of the CTSD protein. This decrease may be associated with neuronal death and impaired synaptic function. In addition, CTSD protein may also be associated with motor symptoms in patients with Parkinson's disease.

In which diseases does the CTSD protein play a role?

CTSD proteins play a role in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. It may change in these diseases, leading to structural alterations and impaired signaling of neuronal synapses.