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Cathepsin D Inhibitor Screening Kit
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Cat.No. : | Kit-0264 Optional Service: Optional requirements on this protein |
Product Overview : | CTSD Inhibitor Screening Kit is used for screening cathepsin D inhibitor. |
Description : | Apoptosis can be mediated by mechanisms other than the traditional caspase-mediated cleavage cascade. There is growing recognition that alternative proteolytic enzymes such as the lysosomal cathepsin proteases may initiate or propagate proapoptotic signals. Cathepsins are lysosomal enzymes that are also used as sensitive markers in various toxicological investigations. The Cathepsin D Activity Assay kit is a fluorescence-based assay that utilizes the preferred cathepsin D substrate sequence GKPILFFRLK(DNP)-D-R- NH2) labeled with MCA. Cathepsin D will cleave the synthetic substrate to release the quenched fluorescent group MCA, which can then easily be measured using a fluorometer or fluorescence plate reader at Ex/Em = 328/460 nm. The relative efficacy of test inhibitors are compared to the positive control inhibitor, Pepstatin A (IC50< 0.1 nM). The Cathepsin D assay is simple, straightforward, and can be adapted to 96-well plate assays and is suitable for high throughput screening (HTS). |
Storage : | Store kit at -20°C (Store CD Reaction Buffer at 4°C after opening). Protect CD Substrate from light. Store Cathepsin D vial at -80°C. All reagents are stable for 6 months under proper storage conditions. |
◆ Recombinant Protein
CTSD-435C | Recombinant Cricetulus Griseus CTSD Protein (65-408 aa), His-SUMO-tagged | +Inquiry |
CTSD-2103H | Recombinant Human CTSD Protein, GST-tagged | +Inquiry |
Ctsd-2369M | Recombinant Mouse Ctsd Protein, His-tagged | +Inquiry |
CTSD-877H | Recombinant Human CTSD Protein, His-tagged | +Inquiry |
CTSD-2758H | Recombinant Human CTSD protein, GST-tagged | +Inquiry |
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◆ Native Protein
CTSD-5325D | Native Human CTSD protein | +Inquiry |
CTSD-1648H | Native Human Cathepsin D | +Inquiry |
CTSD-27858TH | Native Human CTSD | +Inquiry |
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◆ Lysates
CTSD-1735HCL | Recombinant Human CTSD cell lysate | +Inquiry |
CTSD-3023MCL | Recombinant Mouse CTSD cell lysate | +Inquiry |
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