Active Recombinant Human CTSD protein, His-tagged
|Product Overview :||Recombinant Human CTSD protein, fused to His-tag, was expressed in HEK293.|
- Gene Information
- Related Products
|Description :||This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.|
|Form :||Liquid in. 50mM MES buffer (pH 5.5) containing 100mM NaCl, 20% glycerol.|
|Bio-activity :||Specific activity is > 20 pmol/min/ug, and is defined as the amount of enzyme that cleaves 1pmol of Mca-PLGL-Dpa-AR-NH2 per minute at pH 3.5 at 25 centigrade.|
|Molecular Mass :||43.4 kDa|
|Protein length :||21-412aa|
|AA Sequence :||LVRIPLHKFT SIRRTMSEVG GSVEDLIAKG PVSKYSQAVP AVTEGPIPEV LKNYMDAQYY GEIGIGTPPQ CFTVVFDTGS SNLWVPSIHC KLLDIACWIH HKYNSDKSST YVKNGTSFDI HYGSGSLSGY LSQDTVSVPC QSASSASALG GVKVERQVFG EATKQPGITF IAAKFDGILG MAYPRISVNN VLPVFDNLMQ QKLVDQNIFS FYLSRDPDAQ PGGELMLGGT DSKYYKGSLS YLNVTRKAYW QVHLDQVEVA SGLTLCKEGC EAIVDTGTSL MVGPVDEVRE LQKAIGAVPL IQGEYMIPCE KVSTLPAITL KLGGKGYKLS PEDYTLKVSQ AGKTLCLSGF MGMDIPPPSG PLWILGDVFI GRYYTVFDRD NNRVGFAEAA RL
|Endotoxin :||< 1 EU per 1ug of protein (determined by LAL method).|
|Purity :||> 95%|
|Applications :||SDS-PAGE, Enzyme Activity|
|Storage :||Can be stored at 2 centigrade to 8 centigrade for 1 week. For long term storage, aliquot and store at -20 centigrade to -80 centigrade. Avoid repeated freezing and thawing cycles.|
|Concentration :||1 mg/ml|
|Gene Name :||CTSD cathepsin D [ Homo sapiens (human) ]|
|Official Symbol :||CTSD|
|Synonyms :||CPSD; CTSD; Cathepsin D; CLN10; HEL-S-130P; lysosomal aspartyl protease; lysosomal aspartyl peptidase; lysosomal aspartyl protease|
|Gene ID :||1509|
|mRNA Refseq :||NM_001909|
|Protein Refseq :||NP_001900|
|UniProt ID :||P07339|
|◆ Recombinant Protein|
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|CTSD-913R||Recombinant Rhesus Macaque CTSD Protein, His (Fc)-Avi-tagged||+Inquiry|
|CTSD-786H||Recombinant Human CTSD Protein, His-tagged||+Inquiry|
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|◆ Native Protein|
|CTSD-1648H||Active Native Human Cathepsin D||+Inquiry|
|CTSD-5325D||Active Native Human CTSD protein||+Inquiry|
|CTSD-189H||Active Native Human Cathepsin D||+Inquiry|
|CTSD-3023MCL||Recombinant Mouse CTSD cell lysate||+Inquiry|
|CTSD-1735HCL||Recombinant Human CTSD cell lysate||+Inquiry|
|◆ Assay kits|
|Kit-0264||Cathepsin D Inhibitor Screening Kit||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
There is an association between CTSD proteins and cognitive function. In some neurodegenerative diseases, abnormal accumulation and deposition of CTSD proteins may affect neuronal signaling and synaptic function, leading to a decline in cognitive function.
In some neurodegenerative diseases, levels of the CTSD protein may change. For example, people with Alzheimer's disease may have elevated levels of the CTSD protein. These changes may help in the diagnosis of the disease and in the assessment of the course of the disease.
For people with cognitive decline, their CTSD protein levels can be assessed by a blood or cerebrospinal fluid sample. This evaluation can help doctors understand whether the cause of cognitive decline is related to a neurodegenerative disease.
It is currently no treatment that directly targets the CTSD protein. However, some medications can reduce symptoms of neurodegenerative diseases, such as cholinesterase inhibitors such as donepezil, which can increase acetylcholine levels in synapses, which can improve cognitive function.
People with Parkinson's disease may have reduced levels of the CTSD protein. This decrease may be associated with neuronal death and impaired synaptic function. In addition, CTSD protein may also be associated with motor symptoms in patients with Parkinson's disease.
CTSD proteins play a role in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. It may change in these diseases, leading to structural alterations and impaired signaling of neuronal synapses.
Customer Reviews (3)Write a review
Good at western-blot experiments. -
In experiments, the biocompatibility performed well. -
The experimental conditions are broad, and the experimental results are accurate and repeatable. -
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