Recombinant Mouse Ctsd Protein, His-tagged

Cat.No. : Ctsd-2369M
Product Overview : Purified recombinant protein of Mouse cathepsin D (Ctsd) with a C-His tag was expressed in HEK293.
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Description : Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.
Source : HEK293
Species : Mouse
Tag : His
Molecular Mass : 43.9 kDa
AA Sequence : IIRIPLRKFTSIRRTMTEVGGSVED LILKGPITKYSMQSSPKTTEPVSEL LKNYLDAQYYGDIGIGTPPQCFTVV FDTGSSNLWVPSIHCKILDIACWVH HKYNSDKSSTYVKNGTSFDIHYGSG SLSGYLSQDTVSVPCKSDQSKARGI KVEKQIFGEATKQPGIVFVAAKFDG ILGMGYPHISVNNVLPVFDNLMQQK LVDKNIFSFYLNRDPEGQPGGELML GGTDSKYYHGELSYLNVTRKAYWQV HMDQLEVGNELTLCKGGCEAIVDTG TSLLVGPVEEVKELQKAIGAVPLIQ GEYMIPCEKVSSLPTVYLKLGGKNY ELHPDKYILKVSQGGKTICLSGFMG MDIPPPSGPLWILGDVFIGSYYTVF DRDNNRVGFANAVVLVDHHHHHH
Endotoxin : < 0.1 ng/μg of protein (< 1 EU/μg)
Purity : > 95% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Storage : Store at -80 centigrade.
Storage Buffer : LyopH ilized from a 0.2 μM filtered solution of 20 mM MES, 150 mM NaCl, pH 5.5
Reconstitution : Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in 1×PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Gene Name : Ctsd cathepsin D [ Mus musculus (house mouse) ]
Official Symbol : Ctsd
Synonyms : CTSD; cathepsin D; CD; CatD
Gene ID : 13033
mRNA Refseq : NM_009983
Protein Refseq : NP_034113
UniProt ID : P18242

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What is the relationship between CTSD proteins and cognitive function? 05/02/2022

There is an association between CTSD proteins and cognitive function. In some neurodegenerative diseases, abnormal accumulation and deposition of CTSD proteins may affect neuronal signaling and synaptic function, leading to a decline in cognitive function.

What is the relationship between changes in CTSD protein levels and disease? 12/13/2021

In some neurodegenerative diseases, levels of the CTSD protein may change. For example, people with Alzheimer's disease may have elevated levels of the CTSD protein. These changes may help in the diagnosis of the disease and in the assessment of the course of the disease.

For people with cognitive decline, how do you assess their CTSD protein levels? 01/19/2021

For people with cognitive decline, their CTSD protein levels can be assessed by a blood or cerebrospinal fluid sample. This evaluation can help doctors understand whether the cause of cognitive decline is related to a neurodegenerative disease.

How can treatment be used to alter the level or function of the CTSD protein? 11/14/2020

It is currently no treatment that directly targets the CTSD protein. However, some medications can reduce symptoms of neurodegenerative diseases, such as cholinesterase inhibitors such as donepezil, which can increase acetylcholine levels in synapses, which can improve cognitive function.

Is CTSD protein involved in Parkinson's disease? 02/08/2020

People with Parkinson's disease may have reduced levels of the CTSD protein. This decrease may be associated with neuronal death and impaired synaptic function. In addition, CTSD protein may also be associated with motor symptoms in patients with Parkinson's disease.

In which diseases does the CTSD protein play a role? 12/11/2019

CTSD proteins play a role in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. It may change in these diseases, leading to structural alterations and impaired signaling of neuronal synapses.

Customer Reviews (3)

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Reviews
07/12/2021

    Good at western-blot experiments. -

    03/28/2021

      In experiments, the biocompatibility performed well. -

      03/02/2021

        The experimental conditions are broad, and the experimental results are accurate and repeatable. -

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