Recombinant Mouse Ctsd Protein, His-tagged
|Product Overview :||Purified recombinant protein of Mouse cathepsin D (Ctsd) with a C-His tag was expressed in HEK293.|
- Gene Information
- Related Products
|Description :||Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.|
|Molecular Mass :||43.9 kDa|
|AA Sequence :||IIRIPLRKFTSIRRTMTEVGGSVED LILKGPITKYSMQSSPKTTEPVSEL LKNYLDAQYYGDIGIGTPPQCFTVV FDTGSSNLWVPSIHCKILDIACWVH HKYNSDKSSTYVKNGTSFDIHYGSG SLSGYLSQDTVSVPCKSDQSKARGI KVEKQIFGEATKQPGIVFVAAKFDG ILGMGYPHISVNNVLPVFDNLMQQK LVDKNIFSFYLNRDPEGQPGGELML GGTDSKYYHGELSYLNVTRKAYWQV HMDQLEVGNELTLCKGGCEAIVDTG TSLLVGPVEEVKELQKAIGAVPLIQ GEYMIPCEKVSSLPTVYLKLGGKNY ELHPDKYILKVSQGGKTICLSGFMG MDIPPPSGPLWILGDVFIGSYYTVF DRDNNRVGFANAVVLVDHHHHHH|
|Endotoxin :||< 0.1 ng/μg of protein (< 1 EU/μg)|
|Purity :||> 95% as determined by SDS-PAGE and Coomassie blue staining|
|Stability :||Stable for at least 6 months from date of receipt under proper storage and handling conditions.|
|Storage :||Store at -80 centigrade.|
|Storage Buffer :||LyopH ilized from a 0.2 μM filtered solution of 20 mM MES, 150 mM NaCl, pH 5.5|
|Reconstitution :||Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in 1×PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.|
|Gene Name :||Ctsd cathepsin D [ Mus musculus (house mouse) ]|
|Official Symbol :||Ctsd|
|Synonyms :||CTSD; cathepsin D; CD; CatD|
|Gene ID :||13033|
|mRNA Refseq :||NM_009983|
|Protein Refseq :||NP_034113|
|UniProt ID :||P18242|
|◆ Recombinant Protein|
|CTSD-877H||Recombinant Human CTSD Protein, His-tagged||+Inquiry|
|CTSD-435C||Recombinant Cricetulus Griseus CTSD Protein (65-408 aa), His-SUMO-tagged||+Inquiry|
|CTSD-913R||Recombinant Rhesus Macaque CTSD Protein, His (Fc)-Avi-tagged||+Inquiry|
|CTSD-786H||Recombinant Human CTSD Protein, His-tagged||+Inquiry|
|CTSD-2752H||Recombinant Human CTSD Protein, His (Fc)-Avi-tagged||+Inquiry|
|◆ Native Protein|
|CTSD-27858TH||Native Human CTSD||+Inquiry|
|CTSD-1648H||Active Native Human Cathepsin D||+Inquiry|
|CTSD-5325D||Active Native Human CTSD protein||+Inquiry|
|CTSD-1735HCL||Recombinant Human CTSD cell lysate||+Inquiry|
|CTSD-3023MCL||Recombinant Mouse CTSD cell lysate||+Inquiry|
|◆ Assay kits|
|Kit-0264||Cathepsin D Inhibitor Screening Kit||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
There is an association between CTSD proteins and cognitive function. In some neurodegenerative diseases, abnormal accumulation and deposition of CTSD proteins may affect neuronal signaling and synaptic function, leading to a decline in cognitive function.
In some neurodegenerative diseases, levels of the CTSD protein may change. For example, people with Alzheimer's disease may have elevated levels of the CTSD protein. These changes may help in the diagnosis of the disease and in the assessment of the course of the disease.
For people with cognitive decline, their CTSD protein levels can be assessed by a blood or cerebrospinal fluid sample. This evaluation can help doctors understand whether the cause of cognitive decline is related to a neurodegenerative disease.
It is currently no treatment that directly targets the CTSD protein. However, some medications can reduce symptoms of neurodegenerative diseases, such as cholinesterase inhibitors such as donepezil, which can increase acetylcholine levels in synapses, which can improve cognitive function.
People with Parkinson's disease may have reduced levels of the CTSD protein. This decrease may be associated with neuronal death and impaired synaptic function. In addition, CTSD protein may also be associated with motor symptoms in patients with Parkinson's disease.
CTSD proteins play a role in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. It may change in these diseases, leading to structural alterations and impaired signaling of neuronal synapses.
Customer Reviews (3)Write a review
Good at western-blot experiments. -
In experiments, the biocompatibility performed well. -
The experimental conditions are broad, and the experimental results are accurate and repeatable. -
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