CX3CR1 Protein


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Official Full Name chemokine (C-X3-C motif) receptor 1
Background Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Synonyms CX3CR1; chemokine (C-X3-C motif) receptor 1; V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1; CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1;
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His/GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CX3CR1-2150H Recombinant Human CX3CR1 Protein, GST-tagged Wheat Germ GST
    Human CX3CR1-28062TH Recombinant Human CX3CR1 Wheat Germ N/A
    Rat CX3CR1-1684R Recombinant Rat CX3CR1 Protein Mammalian Cell His
    Rhesus Macaque CX3CR1-1103R Recombinant Rhesus monkey CX3CR1 Protein, His-tagged Mammalian Cell His
    Human CX3CR1-7173HCL Recombinant Human CX3CR1 293 Cell Lysate HEK293 N/A
    Human CX3CR1-220H Recombinant Human CX3CR1 Protein, His/GST-tagged E. coli His/GST
    Kit-1024 Tumor-derived Exosome enrichment and Quantification Assay Kit (Biological Fluids/Cell Media, Colorimetric) N/A
    Kit-1187 CX3CR1 CHO-K1 β-Arrestin GPCR Assay Kit N/A

    CX3CR1 involved in several pathways and played different roles in them. We selected most pathways CX3CR1 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CX3CR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chemokine receptors bind chemokines CCR9; CX3CR1; CCR6; AMCF-II; CXCL13; CCR8; CCR7; CXCL11.8; CCR3; CCL35.1
    Chemokine signaling pathway HRAS; GNB3; PXN; CCL4L1; STAT2; JAK3; GNG2; AMCF-II; GM13304; RAP1A
    Class A/1 (Rhodopsin-like receptors) PROK2; SAA1; PYYA; GPR132; HRH3; S1PR3; CHRM5; AMCF-II; SSTR5; PENKA
    Cytokine-cytokine receptor interaction GM2002; IFNA7; IL22RA1; CCL20A.3; CXCR3; CCL6; IFNW1; BMPR1BB; KITLG; XCL2
    GPCR ligand binding RGS1; EMR1; GPR31; GPR55A; CRHR2; FPR-RS3; CNR2; OPN1SW1; CCL27; PROK2
    GPCRs, Class A Rhodopsin-like NPFFR2; AGTR2; GPR20; OPN1SW; GPR77; FFAR3; SSTR4; OR3A4P; CCR3; ADORA3
    Peptide GPCRs CXCR6; SSTR1; CX3CR1; TAC4; SSTR5; SSTR4
    Peptide ligand-binding receptors CX3CR1; PYY; PENKA; NPB; UTS2; KISS1; PRLH; CCL35.2; GPR37B; RLN3

    CX3CR1 has several biochemical functions, for example, C-X3-C chemokine receptor activity, chemokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CX3CR1 itself. We selected most functions CX3CR1 had, and list some proteins which have the same functions with CX3CR1. You can find most of the proteins on our site.

    Function Related Protein
    C-X3-C chemokine receptor activity CX3CR1
    chemokine receptor activity XCR1; ACKR3B; CXCR4A; CCBP2; CCR6; CCRL2; CCR5; RGRA; RGRB; CCR12A
    protein binding GTF2A1; BLOC1S3; CCNB1; HAND2; AURKA; NARG1; C16orf53; NDUFA13; C19orf57; MAP1S

    CX3CR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CX3CR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CX3CR1.

    Sugaya, M; et al. Chemokines and Skin Diseases. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 63:109-115(2015).
    Bian, C; Zhao, ZQ; et al. Involvement of CX3CL1/CX3CR1 Signaling in Spinal Long Term Potentiation. PLOS ONE 10:-(2015).

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