• Official Full Name

    chemokine (C-X3-C motif) receptor 1

  • Background

    Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
  • Synonyms

    CX3CR1; chemokine (C-X3-C motif) receptor 1; V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1; CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1;
    • Type:
    • Assay Kits
    • Cell & Tissue Lysates
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Kit-1024 Tumor-derived Exosome enrichment and Quantification Assay Kit (Biological Fluids/Cell Media, Colorimetric) N/A
    Kit-1187 CX3CR1 CHO-K1 β-Arrestin GPCR Assay Kit N/A
    Human CX3CR1-7173HCL Recombinant Human CX3CR1 293 Cell Lysate HEK293 N/A
    Human CX3CR1-28062TH Recombinant Human CX3CR1 Wheat Germ N/A
    Human CX3CR1-2150H Recombinant Human CX3CR1 Protein, GST-tagged Wheat Germ GST
    Human CX3CR1-220H Recombinant Human CX3CR1 Protein, His/GST-tagged E. coli His/GST
    Rat CX3CR1-1343R Recombinant Rat CX3CR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat CX3CR1-1343R-B Recombinant Rat CX3CR1 Protein Pre-coupled Magnetic Beads HEK293
    Rat CX3CR1-1684R Recombinant Rat CX3CR1 Protein Mammalian Cell His
    Rhesus Macaque CX3CR1-1103R Recombinant Rhesus monkey CX3CR1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CX3CR1-928R Recombinant Rhesus Macaque CX3CR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque CX3CR1-928R-B Recombinant Rhesus Macaque CX3CR1 Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • CX3CR1 Related Articles
    • CX3CR1 Related Gene Family

    CX3CR1 involved in several pathways and played different roles in them. We selected most pathways CX3CR1 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CX3CR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chemokine receptors bind chemokinesCCR1;CXCL13;ACKR4;CXCR6;CCR3;CCR7;CCR6;CCR8;CX3CR1
    Chemokine signaling pathwayGNG10;VAV3;RAC2;CCL7;STAT5B;DOCK2;GNB4;CCL11;ROCK2
    Class A/1 (Rhodopsin-like receptors)NPSR1;HEBP1;SSTR4;CXCR7B;ADRB2;DRD2;ADRA2C;GAL;CHRM4
    Cytokine-cytokine receptor interactionCCL13;IL20;CXCL10;EPOR;CNTFR;IFNA3;TNFRSF9;CCL3;IRX1
    GPCRs, Class A Rhodopsin-likeSSTR1;NPFFR2;GPR37L1;GPR39;SSTR5;OPN3;CCR9;CNR1;CMKLR1
    Peptide ligand-binding receptorsHCRT;CXCR7B;CXCL11.8;PYYA;GPR37L1;PPY;RLN2;TAC3;EDN3

    CX3CR1 has several biochemical functions, for example, C-X3-C chemokine receptor activity, chemokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CX3CR1 itself. We selected most functions CX3CR1 had, and list some proteins which have the same functions with CX3CR1. You can find most of the proteins on our site.

    Function Related Protein
    C-X3-C chemokine receptor activity
    chemokine receptor activityCCR6A;CCR1L1;CCR3;CCR9A;CCR9;CCBP2;RGRB;PRLH2R;CXCR3.1
    protein bindingCDR2;NUMBL;CARS;DAZAP2;LIG4;AASDHPPT;ZNF148;C9orf24;PARK7

    CX3CR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CX3CR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CX3CR1.

    Sugaya, M; et al. Chemokines and Skin Diseases. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 63:109-115(2015).
    Bian, C; Zhao, ZQ; et al. Involvement of CX3CL1/CX3CR1 Signaling in Spinal Long Term Potentiation. PLOS ONE 10:-(2015).
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