CX3CR1

  • Official Full Name

    chemokine (C-X3-C motif) receptor 1

  • Overview

    Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
  • Synonyms

    CX3CR1; chemokine (C-X3-C motif) receptor 1; V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1; CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chromatography Reagents
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CX3CR1-2947H Active Recombinant Human CX3CR1 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CX3CR1-2150H Recombinant Human CX3CR1 Protein, GST-tagged Wheat Germ GST
Human CX3CR1-28062TH Recombinant Human CX3CR1 Wheat Germ N/A 355 amino acids
Human CX3CR1-7173HCL Recombinant Human CX3CR1 293 Cell Lysate HEK293 N/A
Human CX3CR1-103HF Recombinant Full Length Human CX3CR1 Protein In Vitro Cell Free System 355 amino acids
Human CX3CR1-220H Recombinant Human CX3CR1 Protein, His/GST-tagged E.coli His/GST Met1~Lys103
Human CX3CR1-9543M CX3CR1 Antibody-coupled magnetic MicroBeads
Human CX3CR1-2222HF Recombinant Full Length Human CX3CR1 Protein, GST-tagged In Vitro Cell Free System GST 355 amino acids
Rat CX3CR1-1684R Recombinant Rat CX3CR1 Protein Mammalian Cell His
Rat CX3CR1-1343R Recombinant Rat CX3CR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CX3CR1-1343R-B Recombinant Rat CX3CR1 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL26922BF Recombinant Full Length Bovine Cx3C Chemokine Receptor 1(Cx3Cr1) Protein, His-Tagged E.coli expression system His Full Length (1-358)
Homo sapiens (Human) RFL20493HF Recombinant Full Length Human Cx3C Chemokine Receptor 1(Cx3Cr1) Protein, His-Tagged E.coli expression system His Full Length (1-355)
Mus musculus (Mouse) RFL26790MF Recombinant Full Length Mouse Cx3C Chemokine Receptor 1(Cx3Cr1) Protein, His-Tagged E.coli expression system His Full Length (1-354)
Oryctolagus cuniculus (Rabbit) RFL26864OF Recombinant Full Length Rabbit Cx3C Chemokine Receptor 1(Cx3Cr1) Protein, His-Tagged E.coli expression system His Full Length (1-356)
Rattus norvegicus (Rat) RFL16386RF Recombinant Full Length Rat Cx3C Chemokine Receptor 1(Cx3Cr1) Protein, His-Tagged E.coli expression system His Full Length (1-354)
Rhesus Macaque CX3CR1-1103R Recombinant Rhesus monkey CX3CR1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CX3CR1-928R-B Recombinant Rhesus Macaque CX3CR1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CX3CR1-928R Recombinant Rhesus Macaque CX3CR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Kit-1024 Tumor-derived Exosome enrichment and Quantification Assay Kit (Biological Fluids/Cell Media, Colorimetric) N/A
Kit-1187 CX3CR1 CHO-K1 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CX3CR1 involved in several pathways and played different roles in them. We selected most pathways CX3CR1 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CX3CR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine receptors bind chemokinesCXCL11.8;CCR1;CCR6;CCL35.2;CCL27;CCR9;CXCR6;CXCL13;CCL35.1
Chemokine signaling pathwayGSK3B;GNAI1;CCL19;PF4;RAF1;CCL4L1;CCL22;GNB3;CCL23
Class A/1 (Rhodopsin-like receptors)GPR17;EDN2;GAL;CYSLTR1;PROKR1A;TAC3;S1PR3;GPR37L1;INSL3
Cytokine-cytokine receptor interactionCXCR4B;IL12B;FLT3LG;IL5;TNFRSF10B;IL8L2;GM13306;CSF1RA;TNFRSF21
GPCR ligand bindingOPN1MW2;LTB4R;OXER1;CRHR1;OPN1SW1;AGT;GPRC6A;EDN1;ADRA2B
GPCRs, Class A Rhodopsin-likeHRH3;GPR1;FFAR3;OPN1SW;SSTR1;DRD3;GPR31;SSTR3;CCR8
Peptide GPCRsSSTR5;SSTR1;CX3CR1;TAC4;CXCR6;SSTR4
Peptide ligand-binding receptorsSST1.1;PENK;PROKR1A;NTS;NMBA;KISS1;RLN2;APLN;GAL

CX3CR1 has several biochemical functions, for example, C-X3-C chemokine receptor activity, chemokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CX3CR1 itself. We selected most functions CX3CR1 had, and list some proteins which have the same functions with CX3CR1. You can find most of the proteins on our site.

Function Related Protein
C-X3-C chemokine receptor activity
chemokine receptor activityPRLH2R;CXCR3;CMKLR1;CCR1L1;CXCR4B;CCR3;CCR9A;CCR12A;CXCR3.1
protein bindingZNF511;RNF14;TRAPPC2L;DDX39B;NOP58;PLEKHN1;PPFIA2;FBXO7;BTG1

CX3CR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CX3CR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CX3CR1.

Gene Family

GPCRs

Research Area

Related articles

Sugaya, M; et al. Chemokines and Skin Diseases. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 63:109-115(2015).
Bian, C; Zhao, ZQ; et al. Involvement of CX3CL1/CX3CR1 Signaling in Spinal Long Term Potentiation. PLOS ONE 10:-(2015).
  • Q&As
  • Reviews

Q&As (7)

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Are there therapeutic implications or potential targets related to CX3CR1 in immune-related disorders? 07/27/2022

There are potential therapeutic implications related to CX3CR1 in immune-related disorders, making it a target of interest for drug development.

How does CX3CR1 contribute to the regulation of immune responses and cell migration? 02/23/2019

CX3CR1 contributes to the regulation of immune responses and cell migration by responding to its ligand, fractalkine (CX3CL1).

In which immune cells is CX3CR1 predominantly expressed? 10/21/2018

CX3CR1 is predominantly expressed in certain immune cells, including monocytes, macrophages, and certain subsets of T cells.

How does CX3CR1 influence the balance between immune tolerance and inflammation? 04/04/2018

CX3CR1 plays a role in influencing the balance between immune tolerance and inflammation through its impact on immune cell function.

What diseases or conditions are associated with dysregulation or abnormal expression of CX3CR1? 11/16/2017

Dysregulation or abnormal expression of CX3CR1 is associated with conditions such as atherosclerosis, neuroinflammatory disorders, and certain cancers.

Are there specific chemokines that bind to CX3CR1, and what is their role in immune modulation? 12/04/2016

The ligand for CX3CR1, fractalkine (CX3CL1), is involved in immune modulation, influencing cell adhesion and migration.

What is the primary function of C-X3-C motif chemokine receptor 1 (CX3CR1) in the immune system? 10/19/2016

C-X3-C motif chemokine receptor 1 (CX3CR1) primarily functions in the immune system, playing a role in immune responses and cell migration.

Customer Reviews (3)

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Reviews
09/06/2016

    The manufacturer's commitment to meeting regulatory requirements demonstrated its dedication to ethical research practices.

    04/21/2016

      The reliability of the product's quality and effectiveness from one batch to another instilled confidence in its usage.

      02/08/2016

        The product's adherence to regulatory standards aligned with our lab's commitment to responsible and transparent research.

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