DDR1
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Official Full Name
discoidin domain receptor tyrosine kinase 1
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Overview
The discoidin domain receptors (DDRs) are receptor tyrosine kinases with a discoidin homology repeat in their extracellular domains, activated by binding to extracellular matrix collagens. So far, two mammalian DDRs have been identified: DDR1 and DDR2. Th -
Synonyms
DDR1; discoidin domain receptor tyrosine kinase 1; CAK, discoidin domain receptor family, member 1 , EDDR1, NEP, NTRK4, PTK3A; epithelial discoidin domain-containing receptor 1; CD167; RTK6; tyrosine kinase DDR; cell adhesion kinase; mammary carcinoma ki;
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- C
- hFc
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- Fc|His
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- hIgG1
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- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- DDR1 Related Articles
- DDR1 Related Research Area
DDR1 involved in several pathways and played different roles in them. We selected most pathways DDR1 participated on our site, such as Extracellular matrix organization, Non-integrin membrane-ECM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Extracellular matrix organization | CD151;CEACAM6;TLL2;MMP20;BMP1A;ADAM9;P3H2;COL10A1A;MMP12 |
Non-integrin membrane-ECM interactions | DDR1;DDR2;DMD;LAMC3;TTR;TRAPPC4 |
DDR1 has several biochemical functions, for example, ATP binding, collagen binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDR1 itself. We selected most functions DDR1 had, and list some proteins which have the same functions with DDR1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | PFKFB4L;ADCY9;FGFR2;CDK3;GK5;FASTK;CAMK1DB;MYO1E;CMPK |
collagen binding | ITGA3;ANTXR1;SERPINH1A;GP6;GPR56;PODN;CD44;CTSB;CTSS |
metal ion binding | NR2F6B;GTF3AB;ALPL;CNOT7;CA15C;CYP21A1;PRKCI;ARAF;NEURL3 |
protein binding | CRABP1;ORC4L;TPD52L2;STIM1;CDKN1C;TNFAIP8L2;RAI1;RTN2;CPSF7 |
protein tyrosine kinase collagen receptor activity | DDR2;DDR1 |
transmembrane receptor protein tyrosine kinase activity | DDR1;MUSK;ERBB4;PDGFRA;ERBB3B;IGF1RA;KITA;KDRL;EPHA4B |
DDR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDR1.
NCK2; PTPN11; RGS2; bosutinib; imatinib; dasatinib; SNAPIN; NUDT3; TTR; TM4SF1; MAPK6; BEND5
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