DDR1

  • Official Full Name

    discoidin domain receptor tyrosine kinase 1

  • Overview

    The discoidin domain receptors (DDRs) are receptor tyrosine kinases with a discoidin homology repeat in their extracellular domains, activated by binding to extracellular matrix collagens. So far, two mammalian DDRs have been identified: DDR1 and DDR2. Th
  • Synonyms

    DDR1; discoidin domain receptor tyrosine kinase 1; CAK, discoidin domain receptor family, member 1 , EDDR1, NEP, NTRK4, PTK3A; epithelial discoidin domain-containing receptor 1; CD167; RTK6; tyrosine kinase DDR; cell adhesion kinase; mammary carcinoma ki;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • hFc
  • His
  • DDK
  • DDK|His
  • Fc
  • Fc|His
  • Flag
  • GST
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • Myc
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DDR1-29455TH Active Recombinant Human DDR1 protein, GST-tagged Insect Cell GST
Human DDR1-5432H Recombinant Human DDR1 protein(21-417aa), His-tagged HEK293 C-His 21-417aa
Human DDR1-55H Active Recombinant Human DDR1(492-end) Protein, N-His-tagged Sf21 His 492-end
Human DDR1-814H Recombinant Human DDR1 Protein, DDK-tagged Sf9 Insect Cell DDK
Human DDR1-7297H Active Recombinant Human DDR1 protein(Arg444-Val913), His&GST-tagged Insect Cells N-His&GST Arg444-Val913
Human DDR1-815H Recombinant Human DDR1 Protein, DDK/His-tagged HEK293 DDK/His
Human DDR1-509H Recombinant Human DDR1, GST-tagged Sf9 Insect Cell GST
Human DDR1-212H Recombinant Human DDR1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DDR1-620H Recombinant Human DDR1, His tagged Human Cell His
Human DDR1-2454H Recombinant Human DDR1 Protein, GST-tagged Wheat Germ GST
Human DDR1-816H Recombinant Human DDR1 Protein, DDK-tagged Sf9 Insect Cell DDK
Human DDR1-5688H Recombinant Human DDR1 protein, His-tagged E.coli His His568~Phe829
Human DDR1-219H Recombinant Human DDR1 Protein, DDK-tagged Insect Cell DDK
Human DDR1-2453H Recombinant Human DDR1 Protein Wheat Germ N/A
Human DDR1-2534HCL Recombinant Human DDR1 cell lysate Human Cell N/A
Human DDR1-001HCL Recombinant Human DDR1 cell lysate Insect Cell N/A
Human DDR1-2502HF Recombinant Full Length Human DDR1 Protein, GST-tagged In Vitro Cell Free System GST 22-876 amino acids
Human DDR1-793H Recombinant Human DDR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DDR1-220H Recombinant Human DDR1 Protein, hIgG-His-tagged Insect Cell Fc/His 21-417aa
Human DDR1-1819H Recombinant Human DDR1 protein, GST-tagged E.coli GST 439-530 aa
Human DDR1-826HFL Recombinant Full Length Human DDR1 Protein, C-DDK-tagged Mammalian cells DDK
Human DDR1-1325H Recombinant Human DDR1 Protein, His-tagged E.coli N-His Asp21-Ala417
Human DDR1-6029H Recombinant Human DDR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DDR1-1942H Active Recombinant Human DDR1 protein, Fc-tagged HEK293 Fc Asp21-Thr416
Human DDR1-1331HFL Recombinant Full Length Human DDR1 Protein, C-Flag-tagged Mammalian cells Flag
Human DDR1-4H Recombinant Human DDR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DDR1-2853H Recombinant Human DDR1 protein, His-tagged E.coli His 439-530 aa
Human DDR1-5165H Recombinant Human DDR1 protein(Met1-Thr416), His-tagged HEK293 C-His Met1-Thr416
Human DDR1-143H Recombinant Human DDR1 Protein, C-His-tagged E.coli C-His
Human DDR1-4H-B Recombinant Human DDR1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ddr1-391M Active Recombinant Mouse Discoidin Domain Receptor Family, Member 1 Mammalian cells N/A
Mouse Ddr1-7402M Active Recombinant Mouse Ddr1 protein(Leu444-Val874), His&GST-tagged Insect Cells N-His&GST Leu444-Val874
Mouse Ddr1-6919M Recombinant Mouse Ddr1 protein, hFc-tagged HEK293 hFc Met1-Thr414
Mouse Ddr1-1150M Recombinant Mouse Ddr1 protein, His-tagged HEK293 His Met1-Thr414
Mouse DDR1-401MCL Recombinant Mouse DDR1 cell lysate Insect Cell N/A
Mouse DDR1-1709MCL Recombinant Mouse DDR1 cell lysate Human Cell N/A
Mouse Ddr1-10533M Recombinant Mouse Ddr1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ddr1-1151M Recombinant Mouse Ddr1 Protein(Asp22-Ala415), His-tagged HEK293 C-His Asp22-Ala415
Mouse Ddr1-10533M-B Recombinant Mouse Ddr1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ddr1-741M Recombinant Mouse Ddr1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Ddr1-53R Recombinant Rat Ddr1, Fc tagged Human Cell His
Rat Ddr1-8808R Recombinant Rat Ddr1, His tagged Human Cell His
Rat DDR1-1081RCL Recombinant Rat DDR1 cell lysate Human Cell N/A
Rat DDR1-1353R Recombinant Rat DDR1 protein(Met1-Thr413), hFc-tagged HEK293 C-hFc Met1-Thr413
Rhesus monkey DDR1-1209R Recombinant Rhesus monkey DDR1 Protein, His-tagged HEK293 His
Rhesus monkey DDR1-1593R Recombinant Rhesus Monkey DDR1 Protein HEK293 N/A
Rhesus monkey DDR1-1594R Recombinant Rhesus Monkey DDR1 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey DDR1-1595R Recombinant Rhesus Monkey DDR1 Protein, hIgG4-tagged HEK293 hIgG4
Rhesus Macaque DDR1-1034R Recombinant Rhesus Macaque DDR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DDR1-1034R-B Recombinant Rhesus Macaque DDR1 Protein Pre-coupled Magnetic Beads HEK293
Kit-1560 U2OS DDR1 Bioassay Kit N/A
Kit-1579 DDR1 Functional Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

DDR1 involved in several pathways and played different roles in them. We selected most pathways DDR1 participated on our site, such as Extracellular matrix organization, Non-integrin membrane-ECM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Extracellular matrix organizationCEACAM1;PPIB;MATN4;BMP1B;P3H2;FBN2;CMA1;COL3A1;ADAMTS8
Non-integrin membrane-ECM interactionsDMD;DDR2;LAMC3;TTR;TRAPPC4;DDR1

DDR1 has several biochemical functions, for example, ATP binding, collagen binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDR1 itself. We selected most functions DDR1 had, and list some proteins which have the same functions with DDR1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingEHD4;RBKS;DNAJA3A;UBE2G1A;HARS2;NAIP6;UBA1;SKIV2L;DYNC1LI2
collagen bindingVWF;DCN;NID2;CTSL1;RELL2;GP6;SERPINH1A;DDR1;Pdgfa&Pdgfb
metal ion bindingGNAT1;RNF11A;ZNF497;FREM1;UGP2;ZNF501;FLYWCH1;NRP2A;ACVR1
protein bindingTRAPPC2L;NTM;DIAP1;LATS2;EIF5B;ANP32A;PLK1S1;PBRM1;CRADD
protein tyrosine kinase collagen receptor activityDDR1;DDR2
transmembrane receptor protein tyrosine kinase activityLTK;EPHB4B;IGF1RA;EK1;RYK;ROR2;NTRK1;EPHB4;CSF1RA

DDR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDR1.

NCK2; PTPN11; RGS2; bosutinib; imatinib; dasatinib; SNAPIN; NUDT3; TTR; TM4SF1; MAPK6; BEND5

Research Area

Related articles

Favreau, AJ; Vary, CPH; et al. Cryptic collagen IV promotes cell migration and adhesion in myeloid leukemia. CANCER MEDICINE 3:265-272(2014).
Carafoli, F; Hohenester, E; et al. Collagen recognition and transmembrane signalling by discoidin domain receptors. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1834:2187-2194(2013).
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