DNM1L
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Official Full Name
dynamin 1-like
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Overview
The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related;subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do;not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a;role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts;encoding different isoforms. These transcripts are alternatively polyadenylated. -
Synonyms
DNM1L; dynamin 1-like; dynamin-1-like protein; DRP1; DVLP; DYMPLE; HDYNIV; VPS1; dynamin-like protein 4; dynamin-like protein IV; Dnm1p/Vps1p-like protein; dynamin-related protein 1; dynamin family member proline-rich carboxyl-terminal domain less; DLP1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
DNM1L involved in several pathways and played different roles in them. We selected most pathways DNM1L participated on our site, such as Apoptosis, Apoptotic execution phase, Programmed Cell Death, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNM1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | OCLN;IL3RA;DSG1;PRKACB;HIST1H1A;NTRK1;NFKBIAA;BOK;HIST1H1B |
| Apoptotic execution phase | HIST1H1C;VIML;DBNLA;SPNA2;PLEC;DBNL;BMX;STK24;STK24A |
| Programmed Cell Death | MLKL;STK26;PANK1A;DBNLA;GZMF;GAS2;HMGB2A;STK24B;DBNLB |
| Synaptic Vesicle Pathway | SYP;DNM1L;SYN3;STX1B;SYN2;SYN1;PARK7;CPLX2 |
| TNF signaling pathway | BIRC3;MAP2K1;CASP10;CREB3L3;Casp3;CFLAR;BAG4;PGAM5;PIK3CA |
DNM1L has several biochemical functions, for example, GTP binding, GTPase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DNM1L itself. We selected most functions DNM1L had, and list some proteins which have the same functions with DNM1L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | RERGLA;NOLC1;GBP1;EFTUD2;RAN;DNM1A;RAB22A;RALBA;RAP2C |
| GTPase activity | SEPT9;GNGT2;DIRAS3;GNB1;RAB3AA;TUBA3D;RABL2;TUBB5;IRGF1 |
| identical protein binding | SDK2;ANXA4;PRPF19;SMAD1;TYROBP;CLDND;ZNF703;IAPP;LTBR |
| lipid binding | YBX2;FABP6;CRABP1B;PITPNC1;STARD10;VCP;RASGRP2;EPN2;SEC14L3 |
| protein binding | STAG1;FAM117B;TFAM;DOCK1;SIT1;SHC3;EGLN1;NSL1;CCNC |
| protein homodimerization activity | BOKB;RNF40;RENBP;E2F8;NPR3;ADAM10;GRIK2;XDH;MBL1 |
| ubiquitin protein ligase binding | ARRB1;FOXO1;UBE2KA;DLG3;SUMO2;CASP10;SLC25A5;TRAF4;TP53 |
DNM1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNM1L here. Most of them are supplied by our site. Hope this information will be useful for your research of DNM1L.
LRRK2; MIEF2; MIEF1
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewIncrease yield and purity and improve production efficiency in biotechnology production.
Good fluorescence labeling performance in light microscopy technology, which is helpful for cell imaging studies.
In vaccine research, it has been found that it can induce immune protective effect and has potential for disease prevention.
Q&As (6)
Ask a questionA mutation in the DNM1L gene may have a genetic predisposition, meaning that the mutation is more likely to occur in a patient's family member.
DNM1L is involved in the regulation of neuronal connections and synaptic function, especially in the endocytosis and release process of synaptic vesicles, thereby affecting the transmission of neural signals.
DNM1L gene mutations can be transmitted in different genetic ways such as autosomal dominant, dominant negative, and dominant homosexual, depending on the type and location of the mutation.
DNM1L gene mutations are associated with a number of neurological-related diseases, including Charcot-Marie-Tooth disease, multiple system atrophy, intellectual disability, and movement disorders.
Mutations in the DNM1L gene may be associated with neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and Huntington's disease.
Through long-term follow-up and clinical data analysis of patients, the impact of DNM1L gene mutations on disease prognosis, such as age of onset, disease progression and quality of life, can be evaluated.
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