DNM1L

  • Official Full Name

    dynamin 1-like

  • Overview

    The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related;subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do;not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a;role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts;encoding different isoforms. These transcripts are alternatively polyadenylated.
  • Synonyms

    DNM1L; dynamin 1-like; dynamin-1-like protein; DRP1; DVLP; DYMPLE; HDYNIV; VPS1; dynamin-like protein 4; dynamin-like protein IV; Dnm1p/Vps1p-like protein; dynamin-related protein 1; dynamin family member proline-rich carboxyl-terminal domain less; DLP1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|Myc
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DNM1L-2785H Recombinant Human DNM1L Protein, GST-tagged Wheat Germ GST
Human DNM1L-6859HCL Recombinant Human DNM1L 293 Cell Lysate HEK293 N/A
Human DNM1L-6858HCL Recombinant Human DNM1L 293 Cell Lysate HEK293 N/A
Human DNM1L-199HFL Active Recombinant Full Length Human DNM1L Protein, C-Flag-tagged Mammalian cells Flag
Human DNM1L-2471H Recombinant Human DNM1L Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DNM1L-8494H Recombinant Human DNM1L Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human DNM1L-2584H Recombinant Human DNM1L Protein (1-710 aa), His-Myc-tagged E.coli His/Myc 1-710 aa
Human DNM1L-4043HF Recombinant Full Length Human DNM1L Protein, GST-tagged In Vitro Cell Free System GST 710 amino acids
Human DNM1L-1671H Recombinant Human DNM1L Protein (Met520-Arg736), His tagged E.coli His Met520-Arg736
Human DNM1L-777H-B Recombinant Human DNM1L Protein Pre-coupled Magnetic Beads HEK293
Human DNM1L-3896H Recombinant Human DNM1L Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DNM1L-1672H Recombinant Human DNM1L Protein (Met1-Arg516), N-His tagged E.coli N-His Met1-Arg516
Human DNM1L-8493H Active Recombinant Human DNM1L Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human DNM1L-777H Recombinant Human DNM1L Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DNM1L-2457H Recombinant Human DNM1L protein(501-570 aa), C-His-tagged E.coli C-His 501-570 aa
Mouse DNM1L-4736M Recombinant Mouse DNM1L Protein Mammalian Cell His
Mouse DNM1L-2470M-B Recombinant Mouse DNM1L Protein Pre-coupled Magnetic Beads HEK293
Mouse Dnm1l-2618M Recombinant Mouse Dnm1l Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DNM1L-2470M Recombinant Mouse DNM1L Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DNM1L-1923R Recombinant Rat DNM1L Protein Mammalian Cell His
Rat DNM1L-1582R Recombinant Rat DNM1L Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DNM1L-1582R-B Recombinant Rat DNM1L Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DNM1L-11163Z Recombinant Zebrafish DNM1L Mammalian Cell His
Chicken DNM1L-3555C Recombinant Chicken DNM1L Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DNM1L involved in several pathways and played different roles in them. We selected most pathways DNM1L participated on our site, such as Apoptosis, Apoptotic execution phase, Programmed Cell Death, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNM1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ApoptosisCDK5RAP2;PPP3CCB;AKT1;DYNLL2;PLECA;CAPN2L;HELLS;CASP6;IRAK1
Apoptotic execution phaseHMGB2A;CASP8L1;CTNNB2;PLEC;OCLN;BMX;HIST1H1D;DSG3;CASP6L2
Programmed Cell DeathDSG2;DSP;DBNLA;DBNLB;GZME;MLKL;CASP6L1;DIABLOA;DSG1
Synaptic Vesicle PathwayCPLX2;SYP;SYN3;PARK7;DNM1L;SYN2;STX1B;SYN1
TNF signaling pathwayIL1B;ICAM1;TAB2;PTGS2;TNF;IL15;CXCL10;ATF4;MAGI2

DNM1L has several biochemical functions, for example, GTP binding, GTPase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DNM1L itself. We selected most functions DNM1L had, and list some proteins which have the same functions with DNM1L. You can find most of the proteins on our site.

Function Related Protein
GTP bindingRHOF;RAB7L1;HRAS;ARF1;REM1;EHD2;DIRAS2;TUBA3E;RND3B
GTPase activityRAB1;GNAT1;RAB38;GBP1;RAB34;GNB1;GIMAP7;GNG10;RND2
identical protein bindingSNX1;SLC22A1;TOPBP1;RASSF1;SELK;RAF1;DHX8;CLDN16;TP63
lipid bindingACOT12;RUFY1;INPP4B;APOC2;PRAM1;FFAR1;BAD;DBI;FAM123C
protein bindingWHSC1;DPYSL4;KLHL12;RPS6KA4;FZD8;SEC61G;ZNF550;TBCD;PTPN18
protein homodimerization activityDST;S100A6;ALDH1A3;ANXA9;DSCAML1;NOS2;DAPK3;NOS1;CUL3
ubiquitin protein ligase bindingWASH;UBE2H;GPI1;PML;PRR5L;XRCC5;CDC34A;HSPD1;EIF4E2

DNM1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNM1L here. Most of them are supplied by our site. Hope this information will be useful for your research of DNM1L.

LRRK2; MIEF2; MIEF1

  • Q&As
  • Reviews

Q&As (6)

Ask a question
Does a mutation in the DNM1L gene cause a genetic predisposition? 12/31/2019

A mutation in the DNM1L gene may have a genetic predisposition, meaning that the mutation is more likely to occur in a patient's family member.

What is the relationship between DNM1L and neuronal connectivity and synaptic function? 10/08/2019

DNM1L is involved in the regulation of neuronal connections and synaptic function, especially in the endocytosis and release process of synaptic vesicles, thereby affecting the transmission of neural signals.

What is the inheritance pattern of DNM1L gene mutations? 06/17/2019

DNM1L gene mutations can be transmitted in different genetic ways such as autosomal dominant, dominant negative, and dominant homosexual, depending on the type and location of the mutation.

Which diseases are DNM1L gene mutations associated with? 03/21/2019

DNM1L gene mutations are associated with a number of neurological-related diseases, including Charcot-Marie-Tooth disease, multiple system atrophy, intellectual disability, and movement disorders.

What is the relationship between DNM1L gene mutations and neurodegenerative diseases? 02/02/2019

Mutations in the DNM1L gene may be associated with neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and Huntington's disease.

How to assess the impact of DNM1L gene mutations on disease prognosis? 01/22/2019

Through long-term follow-up and clinical data analysis of patients, the impact of DNM1L gene mutations on disease prognosis, such as age of onset, disease progression and quality of life, can be evaluated.

Customer Reviews (3)

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Reviews
12/10/2020

    Increase yield and purity and improve production efficiency in biotechnology production.

    10/22/2019

      Good fluorescence labeling performance in light microscopy technology, which is helpful for cell imaging studies.

      06/18/2019

        In vaccine research, it has been found that it can induce immune protective effect and has potential for disease prevention.

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