Recombinant Human DNM1L Protein (Met520-Arg736), His tagged
Cat.No. : | DNM1L-1671H |
Product Overview : | Recombinant human DRP1 (Met520-Arg736) fused with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized powder/frozen liquid |
Molecular Mass : | 54.61 kDa |
Protein Length : | Met520-Arg736 |
Purity : | >90% as determined by SDS-PAGE |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | DNM1L dynamin 1-like [ Homo sapiens (human) ] |
Official Symbol : | DNM1L |
Synonyms : | DNM1L; dynamin 1-like; dynamin-1-like protein; DRP1; DVLP; DYMPLE; HDYNIV; VPS1; dynamin-like protein 4; dynamin-like protein IV; Dnm1p/Vps1p-like protein; dynamin-related protein 1; dynamin family member proline-rich carboxyl-terminal domain less; DLP1; EMPF; DYNIV-11; FLJ41912; |
Gene ID : | 10059 |
mRNA Refseq : | NM_005690 |
Protein Refseq : | NP_005681 |
MIM : | 603850 |
UniProt ID : | O00429 |
Products Types
◆ Recombinant Protein | ||
DNM1L-1582R | Recombinant Rat DNM1L Protein, His (Fc)-Avi-tagged | +Inquiry |
DNM1L-2584H | Recombinant Human DNM1L Protein (1-710 aa), His-Myc-tagged | +Inquiry |
DNM1L-8494H | Recombinant Human DNM1L Protein, Myc/DDK-tagged | +Inquiry |
DNM1L-2457H | Recombinant Human DNM1L protein(501-570 aa), C-His-tagged | +Inquiry |
Dnm1l-2618M | Recombinant Mouse Dnm1l Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
DNM1L-6858HCL | Recombinant Human DNM1L 293 Cell Lysate | +Inquiry |
DNM1L-6859HCL | Recombinant Human DNM1L 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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