| Description : |
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
79.4 kDa |
| AA Sequence : |
MEALIPVINKLQDVFNTVGADIIQL PQIVVVGTQSSGKSSVLESLVGRDL LPRGTGIVTRRPLILQLVHVSQEDK RKTTGEENGVEAEEWGKFLHTKNKL YTDFDEIRQEIENETERISGNNKGV SPEPIHLKIFSPNVVNLTLVDLPGM TKVPVGDQPKDIELQIRELILRFIS NPNSIILAVTAANTDMATSEALKIS REVDPDGRRTLAVITKLDLMDAGTD AMDVLMGRVIPVKLGIIGVVNRSQL DINNKKSVTDSIRDEYAFLQKKYPS LANRNGTKYLARTLNRLLMHHIRDC LPELKTRINVLAAQYQSLLNSYGEP VDDKSATLLQLITKFATEYCNTIEG TAKYIETSELCGGARICYIFHETFG RTLESVDPLGGLNTIDILTAIRNAT GPRPALFVPEVSFELLVKRQIKRLE EPSLRCVELVHEEMQRIIQHCSNYS TQELLRFPKLHDAIVEVVTCLLRKR LPVTNEMVHNLVAIELAYINTKHPD FADACGLMNNNIEEQRRNRLARELP SAVSRDKLIQDSRRETKNVASGGGG VGDGVQEPTTGNWRGMLKTSKAEEL LAEEKSKPIPIMPASPQKGHAVNLL DVPVPVARKLSAREQRDCEVIERLI KSYFLIVRKNIQDSVPKAVMHFLVN HVKDTLQSELVGQLYKSSLLDDLLT ESEDMAQRRKEAADMLKALQGASQI IAEIRETHLWTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
