FASLG-5413H
Optional Service: Optional requirements on this protein
Product Overview :
Recombinant Humansoluble FASLG contains 175 amino acid residues and comprises the TNFhomologous region of Fasl.
Description :
FASLG is a type-II transmembraneprotein that belongs to the tumor necrosis factor (TNF) family. Its bindingwith its receptor induces apoptosis. Fas ligand/receptor interactions play animportant role in the regulation of the immune system and the progression ofcancer.
Source :
CHO cells
Species :
Human
Form :
Lyophilized withoutadditives.
Molecular Weight :
19.9 kDa
Purity :
>98% asdetermined by SDS-PAGE analysis.
Endotoxin Level :
<0.1 ng/ug
Biological Activity :
Determined by itsability to induce cytotoxicity in Jurkat cells in the absence of anycross-linking. The EDSO for this effect is<5.0 ng/ml.
Specific Activity :
>2 x 105units/mg
Reconstitution :
Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration of 0.1-1.0 mg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions.
Storage :
Store lyophilizedprotein at -20°C and reconstituted protein in working aliquots at -20°C.Avoid repeated freeze-thaw cycles.
Activationof Pro-Caspase 8; Africantrypanosomiasis; Allograft rejection;Apoptosis; Autoimmune thyroid disease; Calcineurin-regulatedNFAT-dependent transcription in lymphocytes; Calcium signaling in the CD4+ TCR pathway; Caspase-8 is formed from procaspase-8; Death Receptor Signalling; FoxO family signaling; Influenza A; MAPKsignaling pathway; Measles; Pathways in cancer; Type I diabetes mellitus
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.