Recombinant Human Fas Ligand (TNF superfamily, member 6) FASLG-5413H

Recombinant Human Fas Ligand (TNF superfamily, member 6)


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Recombinant Human Fas Ligand (TNF superfamily, member 6)

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Cat.No. : FASLG-5413H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Humansoluble FASLG contains 175 amino acid residues and comprises the TNFhomologous region of Fasl.
Description : FASLG is a type-II transmembraneprotein that belongs to the tumor necrosis factor (TNF) family. Its bindingwith its receptor induces apoptosis. Fas ligand/receptor interactions play animportant role in the regulation of the immune system and the progression ofcancer.
Source : CHO cells
Species : Human
Form : Lyophilized withoutadditives.
Molecular Weight : 19.9 kDa
Purity : >98% asdetermined by SDS-PAGE analysis.
Endotoxin Level : <0.1 ng/ug
Biological Activity : Determined by itsability to induce cytotoxicity in Jurkat cells in the absence of anycross-linking. The EDSO for this effect is<5.0 ng/ml.
Specific Activity : >2 x 105units/mg
Reconstitution : Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration of 0.1-1.0 mg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions.
Storage : Store lyophilizedprotein at -20°C and reconstituted protein in working aliquots at -20°C.Avoid repeated freeze-thaw cycles.
OfficialSymbol : FASLG
Gene Name : FASLG Fas ligand (TNFsuperfamily, member 6) [ Homo sapiens ]
Synonyms : FASLG; Fas ligand(TNF superfamily, member 6); FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1; tumor necrosis factor ligand superfamily member 6; APTL; CD95ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand;apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand)superfamily, member 6
Gene ID : 356
mRNA Refseq : NM_000639
Protein Refseq : NP_000630
MIM : 134638
UniProt ID : P48023
Chromosome Location : 1q23
Pathway : Activationof Pro-Caspase 8; Africantrypanosomiasis; Allograft rejection;Apoptosis; Autoimmune thyroid disease; Calcineurin-regulatedNFAT-dependent transcription in lymphocytes; Calcium signaling in the CD4+ TCR pathway; Caspase-8 is formed from procaspase-8; Death Receptor Signalling; FoxO family signaling; Influenza A; MAPKsignaling pathway; Measles; Pathways in cancer; Type I diabetes mellitus
Function : cytokine activity;protein binding; receptor binding; tumor necrosis factor receptor binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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