Fzd4

  • Official Full Name

    frizzled family receptor 4

  • Overview

    This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins;that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors;are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of;the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and;encoding a shorter isoform has been described, however, its expression is not supported by other experimental;evidence.
  • Synonyms

    FZD4; frizzled family receptor 4; frizzled-4; CD 344; CD 344 antigen; CD344; CD344 antigen; EVR1; FEVR; Frizzled (Drosophila) homolog 4; Frizzled 4; Frizzled homolog 4 (Drosophila); Fz 4; Fz-4; Fz4; FZD4_HUMAN; FZD4S; FzE4; GPCR; hFz4; MGC34390; WNT receptor frizzled 4; cFz-4; frizzled homolog 4;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Chicken
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Rhesus monkey
  • Xenopus laevis (African clawed frog)
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • hFc
  • His
  • Fc
  • GST
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • Flag
  • human|IgG1|Fc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FZD4-305H Active Recombinant Human FZD4 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human FZD4-1540H Recombinant Human FZD4 Protein, His-tagged E.coli N-His Phe37-Trp222
Human FZD4-4592H Recombinant Human FZD4 Protein Wheat Germ N/A
Human FZD4-381H Recombinant Human FZD4 Protein, His-tagged HEK293 His Met1-Glu180
Human FZD4-382H Recombinant Human FZD4 protein, Fc-tagged HEK293 human/IgG1/Fc Phe37-Glu180
Human FZD4-5200H Recombinant Human FZD4 Protein (Met1-Glu180), C-His tagged Mammalian cells C-His Met1-Glu180
Human FZD4-4593H Recombinant Human FZD4 Protein, GST-tagged Wheat Germ GST
Human FZD4-1469H Recombinant Human FZD4 protein, Fc-tagged HEK293 Fc Phe37-Glu180
Human FZD4-5077HF Recombinant Full Length Human FZD4 Protein In Vitro Cell Free System 164 amino acids
Human FZD4-1111HFL Recombinant Human FZD4 protein, His&Flag-tagged HEK293 His&Flag 1-537 aa
Human FZD4-5082HF Recombinant Full Length Human FZD4 Protein, GST-tagged In Vitro Cell Free System GST 537 amino acids
Human FZD4-147H Recombinant Human FZD4 Protein, C-His-tagged E.coli C-His
Human FZD4-256H Recombinant Human FZD4 Protein, Fc-tagged HEK293 Fc 537
Mouse Fzd4-1740M Recombinant Mouse Frizzled Homolog 4 (Drosophila) Mammalian cells N/A
Mouse Fzd4-8308M Recombinant Mouse Fzd4 Mammalian cells N/A
Mouse Fzd4-10558M-B Recombinant Mouse Fzd4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Fzd4-10558M Recombinant Mouse Fzd4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FZD4-2430R Recombinant Rat FZD4 Protein Mammalian Cell His
Rat FZD4-1106R Recombinant Rat FZD4 protein(Met1-Glu181), hFc-tagged HEK293 C-hFc Met1-Glu181
Rat FZD4-1107R Recombinant Rat FZD4 Protein, His-tagged HEK293 His
Rat FZD4-1196RCL Recombinant Rat FZD4 cell lysate Human Cell N/A
Rat FZD4-2086R-B Recombinant Rat FZD4 Protein Pre-coupled Magnetic Beads HEK293
Rat FZD4-2086R Recombinant Rat FZD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey FZD4-1765R Recombinant Rhesus Monkey FZD4 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey FZD4-1764R Recombinant Rhesus Monkey FZD4 Protein HEK293 N/A
Rhesus monkey FZD4-1766R Recombinant Rhesus Monkey FZD4 Protein, hIgG4-tagged HEK293 hIgG4
Gallus gallus (Chicken) RFL24489GF Recombinant Full Length Chicken Frizzled-4(Fzd4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-525)
Homo sapiens (Human) RFL27403HF Recombinant Full Length Human Frizzled-4(Fzd4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (37-537)
Mus musculus (Mouse) RFL25517MF Recombinant Full Length Mouse Frizzled-4(Fzd4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (37-537)
Rattus norvegicus (Rat) RFL26741RF Recombinant Full Length Rat Frizzled-4(Fzd4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (38-538)
Rhesus Macaque FZD4-1776R Recombinant Rhesus monkey FZD4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque FZD4-1597R Recombinant Rhesus Macaque FZD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FZD4-1597R-B Recombinant Rhesus Macaque FZD4 Protein Pre-coupled Magnetic Beads HEK293
Xenopus laevis (African clawed frog) RFL34833XF Recombinant Full Length Xenopus Laevis Frizzled-4(Fzd4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-523)
Chicken FZD4-5675C Recombinant Chicken FZD4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • Fzd4 Related Signal Pathway

Fzd4 involved in several pathways and played different roles in them. We selected most pathways Fzd4 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fzd4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwaySOST;WNT1;RAC1B;RHOAB;WIF1;NFATC3;FZD5;RUVBL1;RHOAD
Hippo signaling pathwayBIRC2;FRMD6;CCND2;WNT9B;TGFB1;TEAD2;Fzd4;BIRC5;CRB2
Signaling pathways regulating pluripotency of stem cellsIL6ST;FZD6;SMAD5;WNT5A;ID1;POU5F1;MAP2K2;WNT1;MEIS1
MelanogenesisFZD1;CAMK2D;WNT2;CALM;WNT1;RAF1B;FZD9;HRASA;WNT7A
HTLV-I infectionSMAD4;HLA-DQA1;PRKACA;HLA-DRB1;TRP53;MSX2;H2-Q10;TNFRSF13C;KAT2A
Pathways in cancerPTGS2;WNT8B;WNT11;RAC2;CYCS;BDKRB2;MLH1;GNAI2;AKT1
Proteoglycans in cancerPTCH1;RRAS2;PLCE1;ARAF;WNT2;AKT1;CAV1;HSPB2;CAV3
Basal cell carcinomaSUFU;DVL3;WNT9A;WNT2;WNT4;FZD1;WNT5B;WNT8B;DVL2

Fzd4 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fzd4 itself. We selected most functions Fzd4 had, and list some proteins which have the same functions with Fzd4. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityOLFR15;OPN1SW1;TAS2R137;OPN1MW4;TAAR2;OLFR473;OPN5;OXTRL;PTAFR
PDZ domain bindingGJA1;LLGL2;ARHGEF16;LRP2;ATP2B4;GRASP;BAIAP2;CLCN3;CXXC4
Wnt-activated receptor activityFZD3;FZD8A;FZD8;FZD1;FZD5;FZD9;FZD6;FZD3B;LRP5
Wnt-protein bindingCTHRC1;PORCN;FZD5;SFRP1A;FZD6;SMO;FZD8B;FZD1;PTPRO
cytokine bindingELANE;CSF1R;KITB;CNTFR;TNFRSF11A;NOG;LIFR;CSF1RA;NRP1
protein bindingSPEF1;RSAD2;ABCD1;BLVRA;LY96;RPL23A;MAGOHB;NCOA2;ORC1L
protein heterodimerization activityPDGFB;PVRL1;SDCBP;ITGB1B;HIST1H2AF;CAV2;HIST1H4C;TAF8;DMRT1
protein homodimerization activityZBTB16;VPS24;PFKM;CASQ2;ACOT7;TENM2;DST;NTRK2;GIMAP7
signal transducer activityAVP;TAAR13B;ILK;GNG7;V2RH32;TAAR12J;RASGRP3;PLCD1;GNGT2A
transmembrane signaling receptor activityNPC1;ENG;OR12D2;SLC22A17;BCAM;TNFRSF10C;ERBB2;OR4N4;FZD7A
ubiquitin protein ligase bindingCDC34A;PCBP2;CUL3;H2-AB1;SMAD3;MAGEA2B;BCL2;ARIH1;HSPA9

Fzd4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fzd4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fzd4.

UBC; Usp8; WNT2B; DLG1; Dlg4; Dlg1; Dlg2

Research Area

Related articles

Paes, KT; Wang, E; et al. Frizzled 4 Is Required for Retinal Angiogenesis and Maintenance of the Blood-Retina Barrier. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 52:6452-6461(2011).
Wang, HX; Tekpetey, FR; et al. Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. MOLECULAR HUMAN REPRODUCTION 15:11-17(2009).
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