Fzd4
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Official Full Name
frizzled family receptor 4
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Overview
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins;that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors;are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of;the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and;encoding a shorter isoform has been described, however, its expression is not supported by other experimental;evidence. -
Synonyms
FZD4; frizzled family receptor 4; frizzled-4; CD 344; CD 344 antigen; CD344; CD344 antigen; EVR1; FEVR; Frizzled (Drosophila) homolog 4; Frizzled 4; Frizzled homolog 4 (Drosophila); Fz 4; Fz-4; Fz4; FZD4_HUMAN; FZD4S; FzE4; GPCR; hFz4; MGC34390; WNT receptor frizzled 4; cFz-4; frizzled homolog 4;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Chicken
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Rhesus monkey
- Xenopus laevis (African clawed frog)
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Fc
- GST
- hIgG4
- His
- Avi
- Flag
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | FZD4-305H | Active Recombinant Human FZD4 Full Length Transmembrane protein(Nanodisc) | HEK293 | Non |
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| Human | FZD4-1540H | Recombinant Human FZD4 Protein, His-tagged | E.coli | His | Phe37-Trp222 |
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| Human | FZD4-4592H | Recombinant Human FZD4 Protein | Wheat Germ | Non |
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| Human | FZD4-381H | Recombinant Human FZD4 Protein, His-tagged | HEK293 | His | Met1-Glu180 |
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| Human | FZD4-382H | Recombinant Human FZD4 protein, Fc-tagged | HEK293 | Fc | Phe37-Glu180 |
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| Human | FZD4-5200H | Recombinant Human FZD4 Protein (Met1-Glu180), C-His tagged | Mammalian cells | His | Met1-Glu180 |
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| Human | FZD4-4593H | Recombinant Human FZD4 Protein, GST-tagged | Wheat Germ | GST |
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| Human | FZD4-1469H | Recombinant Human FZD4 protein, Fc-tagged | HEK293 | Fc | Phe37-Glu180 |
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| Human | FZD4-5077HF | Recombinant Full Length Human FZD4 Protein | In Vitro Cell Free System | 164 amino acids |
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| Human | FZD4-1111HFL | Recombinant Human FZD4 protein, His&Flag-tagged | HEK293 | His&Flag | 1-537 aa |
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| Human | FZD4-5082HF | Recombinant Full Length Human FZD4 Protein, GST-tagged | In Vitro Cell Free System | GST | 537 amino acids |
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| Human | FZD4-147H | Recombinant Human FZD4 Protein, C-His-tagged | E.coli | His |
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| Human | FZD4-256H | Recombinant Human FZD4 Protein, Fc-tagged | HEK293 | Fc | 537 |
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| Mouse | Fzd4-1740M | Recombinant Mouse Frizzled Homolog 4 (Drosophila) | Mammalian cells | Non |
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| Mouse | Fzd4-8308M | Recombinant Mouse Fzd4 | Mammalian cells | Non |
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| Mouse | Fzd4-10558M-B | Recombinant Mouse Fzd4 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | Fzd4-10558M | Recombinant Mouse Fzd4 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rat | FZD4-2430R | Recombinant Rat FZD4 Protein | Mammalian Cell | His |
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| Rat | FZD4-1106R | Recombinant Rat FZD4 protein(Met1-Glu181), hFc-tagged | HEK293 | Fc | Met1-Glu181 |
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| Rat | FZD4-1107R | Recombinant Rat FZD4 Protein, His-tagged | HEK293 | His | Met1-Glu181 |
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| Rat | FZD4-1196RCL | Recombinant Rat FZD4 cell lysate | Human Cell | Non |
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| Rat | FZD4-2086R-B | Recombinant Rat FZD4 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | FZD4-2086R | Recombinant Rat FZD4 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rhesus monkey | FZD4-1765R | Recombinant Rhesus Monkey FZD4 Protein, hIgG1-tagged | HEK293 | Fc | 37-222 |
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| Rhesus monkey | FZD4-1764R | Recombinant Rhesus Monkey FZD4 Protein | HEK293 | Non | 37-222 |
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| Rhesus monkey | FZD4-1766R | Recombinant Rhesus Monkey FZD4 Protein, hIgG4-tagged | HEK293 | hIgG4 | 37-222 |
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| Gallus gallus (Chicken) | RFL24489GF | Recombinant Full Length Chicken Frizzled-4(Fzd4) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (25-525) |
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| Homo sapiens (Human) | RFL27403HF | Recombinant Full Length Human Frizzled-4(Fzd4) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (37-537) |
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| Mus musculus (Mouse) | RFL25517MF | Recombinant Full Length Mouse Frizzled-4(Fzd4) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (37-537) |
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| Rattus norvegicus (Rat) | RFL26741RF | Recombinant Full Length Rat Frizzled-4(Fzd4) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (38-538) |
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| Rhesus Macaque | FZD4-1776R | Recombinant Rhesus monkey FZD4 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | FZD4-1597R | Recombinant Rhesus Macaque FZD4 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rhesus Macaque | FZD4-1597R-B | Recombinant Rhesus Macaque FZD4 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Xenopus laevis (African clawed frog) | RFL34833XF | Recombinant Full Length Xenopus Laevis Frizzled-4(Fzd4) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (23-523) |
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| Chicken | FZD4-5675C | Recombinant Chicken FZD4 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- Fzd4 Related Signal Pathway
Fzd4 involved in several pathways and played different roles in them. We selected most pathways Fzd4 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fzd4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | BAMBIA;FZD9B;DVL1B;PPP3R2;CER1;FZD7A;MMP7;SKP1;DAAM1B |
| Hippo signaling pathway | LLGL2;Fzd4;ID1;WNT5A;AREG;BIRC5;FZD2;ID2;WNT2 |
| Signaling pathways regulating pluripotency of stem cells | PCGF2;WNT16;ACVR1B;DLX5;FZD9;ID1;BMPR2;MEIS1;PIK3R5 |
| Melanogenesis | ADCY2B;PRKCBB;PRKACB;POMCA;WNT16;WNT5B;CREB3L3;MAP2K1;GNAI2 |
| HTLV-I infection | Fzd4;RELA;KAT2A;ANAPC11;NRP1;PPP3R2;WNT4;ANAPC7;H2-Q10 |
| Pathways in cancer | FGF17;TRAF2;FZD1;FGF1;WNT6;MSH3;GNA12;GNAS;SFPI1 |
| Proteoglycans in cancer | PRKACA;PPP1CB;VAV2;ARHGEF1;MAPK1;FZD6;PIK3R1;ANK1;WNT7B |
| Basal cell carcinoma | Fzd4;FZD3;FZD9;APC2;FZD7;TCF7L2;FZD6;WNT5B;FZD8 |
Fzd4 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fzd4 itself. We selected most functions Fzd4 had, and list some proteins which have the same functions with Fzd4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | TAAR12J;OR10H1;CELSR3;CCR9A;GPRC5BB;TAAR12F;CHRM5A;EMR3;OR52J3 |
| PDZ domain binding | ARHGAP29;BAIAP2;DLG3;PLEKHA1;GNG5;CFTR;SLC9A3;ARHGEF16;KIF14 |
| Wnt-activated receptor activity | FZD5;FZD7;LRP6;FZD8B;FZD9B;FZD8A;FZD2;FZD10;FZD3 |
| Wnt-protein binding | PORCN;FZD3A;FZD9;FZD1;SZL;FZD5;FZD8;PTPRO;CTHRC1 |
| cytokine binding | Fzd4;KIT;CD74;KITB;CSF1R;IL31RA;GBP1;CSF1RA;PARK7 |
| protein binding | FXYD7;EED;RPS10;LPHN1;TRAF2;APOBEC3H;MT1H;KLHL12;MTA3 |
| protein heterodimerization activity | TLR1;DRAP1;FLOT2;HIST1H2AG;MCL1A;NTSR1;TGFB2;BCL11A;CD3D |
| protein homodimerization activity | LCN2;MUC13;ANO6;PITX2;JAM3;PYCARD;PYGB;PVRL4;PRTFDC1 |
| signal transducer activity | TAAR10B;TAS2R125;RRH;OLFCG4;NDFIP1;TAAR12C;DKK1;DRD4A;OR103-4 |
| transmembrane signaling receptor activity | MRC1;ENG;FZD7A;CD5;CLEC2D;TLR10;FZD9B;CD72;CD79B |
| ubiquitin protein ligase binding | CUL3A;SPOP;UBE2T;FANCL;GPR19;PIAS2;LTBR;TRIB2;HSPD1 |
Fzd4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fzd4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fzd4.
UBC; Usp8; WNT2B; DLG1; Dlg4; Dlg1; Dlg2
Research Area
Related articles
Paes, KT; Wang, E; et al. Frizzled 4 Is Required for Retinal Angiogenesis and Maintenance of the Blood-Retina Barrier. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 52:6452-6461(2011).
Wang, HX; Tekpetey, FR; et al. Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. MOLECULAR HUMAN REPRODUCTION 15:11-17(2009).
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