Fzd4
-
Official Full Name
frizzled family receptor 4 -
Overview
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins;that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors;are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of;the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and;encoding a shorter isoform has been described, however, its expression is not supported by other experimental;evidence. -
Synonyms
FZD4;frizzled family receptor 4;frizzled-4;CD 344;CD 344 antigen;CD344;CD344 antigen;EVR1;FEVR;Frizzled (Drosophila) homolog 4;Frizzled 4;Frizzled homolog 4 (Drosophila);Fz 4;Fz-4;Fz4;FZD4_HUMAN;FZD4S;FzE4;GPCR;hFz4;MGC34390;WNT receptor frizzled 4;cFz-4;frizzled homolog 4
Recombinant Proteins
- Human
- Rat
- Mouse
- Rhesus macaque
- Chicken
- Mus musculus
- Xenopus laevis
- HEK293
- Mammalian Cells
- Human Cells
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- Non
- Fc
- His
- hIgG4
- Avi
- Flag
- GST
Involved Pathway
Fzd4 involved in several pathways and played different roles in them. We selected most pathways Fzd4 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fzd4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | BMP4,PIK3CD,FN1,TPR,RET,LPAR3,FH1,PRKACG,TCF7L2,CCNE1 |
| Proteoglycans in cancer | FN1,WNT1,PPP1CC,WNT2B,PRKCB,IGF1R,PTPN11,MAPK1,GPC1,TGFB1 |
| Melanogenesis | GNAI2,EDNRB2,FZD6,CREB3L3A,GSK3B,WNT1,PRKACA,CALM1B,PRKACAA,CREB3L2 |
| Signaling pathways regulating pluripotency of stem cells | BMPR1B,LIFR,MAPK3,SOX2,WNT8A,POU5F1,WNT2,WNT5A,SMARCAD1,ACVR2A |
| Wnt signaling pathway | PRICKLE2B,FOSL1A,LEF1,VANGL2,FZD6,SKP1,FZD3B,WNT1,PPP3CB,PPARD |
| HTLV-I infection | WNT2B,FOS,FZD10,VDAC3,DVL3,HLA-DQA2,DVL2,ATF4,PIK3R3,SMAD4 |
| Hippo signaling pathway | CTGF,SMAD1,PPP2R1A,CRB1,TP73,SMAD2,WNT10B,PPP2CA,WNT8A,INADL |
| Basal cell carcinoma | WNT8B,TP53,FZD2,STK36,DVL2,FZD10,GSK3B,WNT6,WNT3A,GLI2 |
Protein Function
Fzd4 has several biochemical functions, for example, G-protein coupled receptor activity,PDZ domain binding,Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fzd4 itself. We selected most functions Fzd4 had, and list some proteins which have the same functions with Fzd4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PDZ domain binding | GRM7,FZD7,PDZK1,GRIK5,SDC2,GNG5,CIT,CADM1,SLC9A3R1,DOCK4 |
| protein homodimerization activity | MYH9,MCL1,HES1,HOMER2,PVRL1,Flt3l,ASMT,SNX2,ADD2,IL6R |
| Wnt-protein binding | FZD7A,FRZB,FZD5,FZD3A,FZD7,SMO,SETD6,GM12824,FZD1,FZD9B |
| transmembrane signaling receptor activity | DNER,IL1R1,CD79A,ICAM1,LGR6,EDAR,CD79B,IL4R.1,TLR9,LYVE1 |
| signal transducer activity | OLFR154,PLCD3,TAS2R121,AIP,BMX,CSPG4,PLEKHB1,ERG,STAT2,TAAR14H |
| cytokine binding | IL31RA,CHRD,CD74,IFNGR1,CNTFR,CSF1RA,CSF1R,ELANE,GBP1,IL17F |
| protein binding | ZSCAN21,MCM5,CPT1B,GIPC2,C1QTNF9,CTNNA1,CNOT7,PHB2,ZFYVE9,FOXB1 |
| protein heterodimerization activity | SMC1A,HIST1H3C,AGTR1A,HOMER2,HIST1H2BM,SOX32,PKNOX1,VEGFA,SNX6,PAFAH1B2 |
| ubiquitin protein ligase binding | POLR2A,SCN5A,UQCRC1,PARK2,UBE2C,HSPA1B,AICDA,BLZF1,RAD18,UBE2NA |
Interacting Protein
Fzd4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fzd4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fzd4.
UBC;Usp8;WNT2B;DLG1;Dlg4;Dlg1;Dlg2
Fzd4 Related Signal Pathway
Resources
Gene Families
Research Area
Related Services
Related Products
References
- Paes, KT; Wang, E; et al. Frizzled 4 Is Required for Retinal Angiogenesis and Maintenance of the Blood-Retina Barrier. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 52:6452-6461(2011).
- Wang, HX; Tekpetey, FR; et al. Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. MOLECULAR HUMAN REPRODUCTION 15:11-17(2009).
