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Official Full Name frizzled family receptor 4
Background This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins;that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors;are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of;the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and;encoding a shorter isoform has been described, however, its expression is not supported by other experimental;evidence.
Synonyms FZD4; frizzled family receptor 4; frizzled-4; CD 344; CD 344 antigen; CD344; CD344 antigen; EVR1; FEVR; Frizzled (Drosophila) homolog 4; Frizzled 4; Frizzled homolog 4 (Drosophila); Fz 4; Fz-4; Fz4; FZD4_HUMAN; FZD4S; FzE4; GPCR; hFz4; MGC34390; WNT receptor frizzled 4; cFz-4; frizzled homolog 4
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Rhesus monkey
    • Source :
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • hIgG1
    • hIgG4
    • His
    • human
    • IgG1
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FZD4-381H Recombinant Human FZD4 Protein, His-tagged HEK293 His
    Human FZD4-382H Recombinant Human FZD4 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human FZD4-4592H Recombinant Human FZD4 Protein Wheat Germ N/A
    Human FZD4-4593H Recombinant Human FZD4 Protein, GST-tagged Wheat Germ GST
    Mouse Fzd4-1740M Recombinant Mouse Frizzled Homolog 4 (Drosophila) Mammalian cells N/A
    Mouse Fzd4-8308M Recombinant Mouse Fzd4 Mammalian cells N/A
    Rat FZD4-1106R Recombinant Rat FZD4 Protein, Fc-tagged HEK293 Fc
    Rat FZD4-1107R Recombinant Rat FZD4 Protein, His-tagged HEK293 His
    Rat FZD4-1196RCL Recombinant Rat FZD4 cell lysate Human Cell N/A
    Rat FZD4-2430R Recombinant Rat FZD4 Protein Mammalian Cell His
    Rhesus monkey FZD4-1764R Recombinant Rhesus Monkey FZD4 Protein HEK293 N/A
    Rhesus monkey FZD4-1765R Recombinant Rhesus Monkey FZD4 Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey FZD4-1766R Recombinant Rhesus Monkey FZD4 Protein, hIgG4-tagged HEK293 hIgG4
    Rhesus Macaque FZD4-1776R Recombinant Rhesus monkey FZD4 Protein, His-tagged Mammalian Cell His
    Chicken FZD4-5675C Recombinant Chicken FZD4 Mammalian Cell His

    Fzd4 involved in several pathways and played different roles in them. We selected most pathways Fzd4 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fzd4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway CER1; WNT11; FZD8A; WNT7AA; WNT11B; PRKACAB; PPP3CA; BAMBIB; WNT3; MAP3K7
    Hippo signaling pathway TCF7L2; WNT7A; PPP2R1B; YWHAB; JUB; ITGB2; BIRC5; TGFB1; SMAD4; NF2
    Signaling pathways regulating pluripotency of stem cells ACVR2A; WNT8B; HNF1A; BMPR1B; AXIN2; FZD1; FGFR2; WNT2; AXIN1; WNT11
    Melanogenesis CALML5; RAF1; WNT4A; DVL3A; WNT1; CREB3L3; GNAO1; PLCB1; WNT5B; KITA
    HTLV-I infection CD3G; PIK3R3; ETS2; WNT3; EGR1; WNT3A; CRTC3; WNT7A; TNF; ITGB2L
    Pathways in cancer BIRC8; LPAR3; PTEN; TRAF6; CASP9; NFKB1; BCL2L1; FLT3LG; FGF3; PAX8
    Proteoglycans in cancer FZD10; CBLC; HPSE2; ROCK2; ACTG1; PTPN6; ITGB1; NANOG; ARAF; TFAP4
    Basal cell carcinoma TCF7L2; TCF7; WNT16; AXIN2; DVL2; TP53; PTCH1; SMO; WNT2B; BMP2

    Fzd4 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fzd4 itself. We selected most functions Fzd4 had, and list some proteins which have the same functions with Fzd4. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor activity MC5RB; OR52B6; RHO; PPYR1; OLFR147; RXFP3.2B; OR7C1; FZD3A; LPAR6A; MRGPRH
    PDZ domain binding LIN7B; TBC1D10A; KIDINS220B; CCDC88C; PTEN; ADRB1; GJA1; ARHGAP29; CLCN3; SNTA1
    Wnt-activated receptor activity FZD7; FZD6; FZD9B; FZD2; LRP5; LRP6; LRP2A; LRP5L; FZD3A; Fzd4
    Wnt-protein binding FZD3; GPR177; SETD6; WLS; FZD3B; FZD3A; FZD7B; SFRP2; FZD5; FZD9B
    cytokine binding IL17F; TNFRSF11A; CSF1R; KITB; KITA; PARK7; CHRD; IFNGR1; GBP1; NOG
    protein binding USF2; GPR158; MYLK2; KLHL7; THOC7; ALDH18A1; TBCD; HHEX; CTBP1; ODAM
    protein heterodimerization activity NOTCH1; HIST1H2B5; KCNK9; PPP3CA; SCUBE1; PIK3R2; SLC3A1; SYT14; KATNB1; HIST1H4G
    protein homodimerization activity IL6ST; VPS24; UPK1A; CAMK2G; IKZF3; CRYM; GALE; IMPA1; BMPR1A; ACTN2
    signal transducer activity TAS2R104; TRIM63; STAT4; OLFR146; APLNRB; OLFR481; STAT1B; MIER1A; OLFCD2; OLFR480
    transmembrane signaling receptor activity MARCO; SELE; IL27RA; KIR2DL4; CD3G; BCAM; LILRB5; GHRHRA; ERBB2; P2RX6
    ubiquitin protein ligase binding LTBR; UBE2G1A; UBE2KB; GSK3B; YWHAE; FBXW7; CDC34A; GPI; TRAF3; YOD1

    Fzd4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fzd4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fzd4.

    UBC; Usp8; WNT2B; DLG1; Dlg4; Dlg1; Dlg2

    Paes, KT; Wang, E; et al. Frizzled 4 Is Required for Retinal Angiogenesis and Maintenance of the Blood-Retina Barrier. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 52:6452-6461(2011).
    Wang, HX; Tekpetey, FR; et al. Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. MOLECULAR HUMAN REPRODUCTION 15:11-17(2009).

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