Recombinant Human FZD4 Protein, GST-tagged

• Cat.No.: FZD4-4593H
• Product Overview: Human FZD4 full-length ORF ( NP_036325.2, 1 a.a. - 537 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 86.3 kDa
• AA Sequence: MAWRGAGPSVPGAPGGVGLSLGLLL QLLLLLGPARGFGDEEERRCDPIRI SMCQNLGYNVTKMPNLVGHELQTDA ELQLTTFTPLIQYGCSSQLQFFLCS VYVPMCTEKINIPIGPCGGMCLSVK RRCEPVLKEFGFAWPESLNCSKFPP QNDHNHMCMEGPGDEEVPLPHKTPI QPGEECHSVGTNSDQYIWVKRSLNC VLKCGYDAGLYSRSAKEFTDIWMAV WASLCFISTAFTVLTFLIDSSRFSY PERPIIFLSMCYNIYSIAYIVRLTV GRERISCDFEEAAEPVLIQEGLKNT GCAIIFLLMYFFGMASSIWWVILTL TWFLAAGLKWGHEAIEMHSSYFHIA AWAIPAVKTIVILIMRLVDADELTG LCYVGNQNLDALTGFVVAPLFTYLV IGTLFIAAGLVALFKIRSNLQKDGT KTDKLERLMVKIGVFSVLYTVPATC VIACYFYEISNWALFRYSADDSNMA VEMLKIFMSLLVGITSGMWIWSAKT LHTWQKCSNRLVNSGKVKREKRGNG WVKPGKGSETVV
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FZD4 frizzled family receptor 4 [ Homo sapiens ]
• Official Symbol: FZD4
• Synonyms: FZD4; frizzled family receptor 4; EVR1, exudative vitreoretinopathy 1, frizzled (Drosophila) homolog 4, frizzled 4, seven transmembrane spanning receptor, frizzled homolog 4 (Drosophila); frizzled-4; CD344; hFz4; frizzled homolog 4; WNT receptor frizzled-4; frizzled 4, seven transmembrane spanning receptor; EVR1; FEVR; Fz-4; FzE4; GPCR; FZD4S; MGC34390
• Gene ID: 8322
• mRNA Refseq: NM_012193
• Protein Refseq: NP_036325
• MIM: 604579
• UniProt ID: Q9ULV1