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|Background||Human cytomegalovirus (CMV) (human herpesvirus 5) glycoprotein B is a 907-amino acid glycoprotein encoded by the ORF of UL55. It is the most abundant component of the envelope with at least two defined neutralizing epitopes, a target of neutralizing antibodies and an essential replication component. The synthesized gB precursor matures into a 130-160 kDa glycoprotein by acquiring N-linked glycosylation modifications, and is cleaved by the cellular protease furin into two components, a 93-116 kDa N-terminal fragment and a 55 kDa C-terminal fragment linked by a disulfide-bond, which is presented on the viral envelope as well as on the surface of virus-infected cells as a covalently associated homodimer. gB plays important roles in HCMV entry, cell-cell spread of internal virions, and fusion of infected cells. It triggers penetration of cells and enhances the spread of infection in nonpolarized human fibroblasts.|
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gB involved in several pathways and played different roles in them. We selected most pathways gB participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with gB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
gB has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by gB itself. We selected most functions gB had, and list some proteins which have the same functions with gB. You can find most of the proteins on our site.
gB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with gB here. Most of them are supplied by our site. Hope this information will be useful for your research of gB.