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Official Full Name hydroxysteroid (11-beta) dehydrogenase 1
Background 11β-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
Synonyms 11-DH; 11-beta-HSD1; CORTRD2; HDL; HSD11; HSD11B; HSD11L; SDR26C1; corticosteroid 11-beta-dehydrogenase isozyme 1; short chain dehydrogenase/reductase family 26C, member 1
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSD11B1-065H Recombinant Human HSD11B1 Protein, His-tagged E. coli His
    Human HSD11B1-019H Recombinant Human HSD11B1 Protein, His-tagged E.coli His
    Human HSD11B1-13951H Recombinant Human HSD11B1 Protein, His-tagged E. coli His
    Human HSD11B1-1415H Recombinant Human HSD11B1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HSD11B1-27736TH Recombinant Human HSD11B1 Wheat Germ N/A
    Human HSD11B1-5060H Recombinant Human HSD11B1 Protein, GST-tagged Wheat Germ GST
    Human HSD11B1-5380HCL Recombinant Human HSD11B1 293 Cell Lysate HEK293 N/A
    Human HSD11B1-5381HCL Recombinant Human HSD11B1 293 Cell Lysate HEK293 N/A
    Mouse Hsd11b1-1175M Recombinant Mouse Hsd11b1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse HSD11B1-7869M Recombinant Mouse HSD11B1 Protein Mammalian Cell His
    Rat HSD11B1-2920R Recombinant Rat HSD11B1 Protein Mammalian Cell His
    Rat Hsd11b1-476R Recombinant Rat Hsd11b1 Protein, His-tagged E.coli His
    Rhesus Macaque HSD11B1-2151R Recombinant Rhesus monkey HSD11B1 Protein, His-tagged Mammalian Cell His

    hsd11b1 involved in several pathways and played different roles in them. We selected most pathways hsd11b1 participated on our site, such as Steroid hormone biosynthesis, Metabolism of xenobiotics by cytochrome P, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with hsd11b1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Steroid hormone biosynthesis HSD17B12B; SRD5A2B; HSD17B7; AKR1D1; HSD17B8; UGT1A6B; CYP3A41B; UGT1A3; CYP11C1; UGT1A2
    Metabolism of xenobiotics by cytochrome P UGT1A4; ALDH3A1; CBR1; CBR2; UGT1A6A; GSTM7; MGST1; AKR7A5; UGT1A6; MGST3
    Metabolic pathways ENPP1; NME4; ENO1A; LTC4S; PKM2; SHMT2; ALDH1B1; GART; NDUFA5; PIGK
    Chemical carcinogenesis HSD11B1; CYP3A43; CYP2C37; AHA-1; UGT1A4; CYP2C50; CYP3A7-CYP3AP1; ADH1A; ADH1C; UGT1A3

    hsd11b1 has several biochemical functions, for example, 11-beta-hydroxysteroid dehydrogenase (NADP+) activity, 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity. Some of the functions are cooperated with other proteins, some of the functions could acted by hsd11b1 itself. We selected most functions hsd11b1 had, and list some proteins which have the same functions with hsd11b1. You can find most of the proteins on our site.

    Function Related Protein
    11-beta-hydroxysteroid dehydrogenase (NADP+) activity HSD11B1
    11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity HSD11B1; HSD11B2

    hsd11b1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hsd11b1 here. Most of them are supplied by our site. Hope this information will be useful for your research of hsd11b1.


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