Recombinant Human HSD11B1 Protein, His-tagged HSD11B1-019H

Recombinant Human HSD11B1 Protein, His-tagged

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Recombinant Human HSD11B1 Protein, His-tagged

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Cat.No. : HSD11B1-019H
Product Overview : Recombinant Human HSD11B1 protein with a N-terminal His-tag was expressed in E.coli
Description : The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 31.4 kDa
Purity : ≥75% estimated by SDS-PAGE
Unit Definition : One unit is defined as the amount of enzyme required to produce 1 nmol of cortisol per minute at 37 centigrade in 50 mM sodium phosphate buffer, pH 7.6, containing 100 mM sodium chloride, using 40 µM cortisone as substrate, and 500 µM NADPH.
Stability : ≥ 6 months
Storage : -80 centigrade
Storage Buffer : 50 mM sodium phosphate buffer, pH 7.6, containing 100 mM sodium chloride and 20% glycerol
Shipping : Dry ice in continental US, may vary elsewhere.
SDS-PAGE analysis of HSD11B1 :

Lane 1: MW Marker
Lane 2: 5 µg Purified 11β-HSD1

Activity of HSD11B1 :

Gene Name : HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 [ Homo sapiens (human) ]
Official Symbol : HSD11B1
Synonyms : HSD11B1; hydroxysteroid 11-beta dehydrogenase 1; HDL; 11-DH; HSD11; HSD11B; HSD11L; CORTRD2; SDR26C1; 11-beta-HSD1; corticosteroid 11-beta-dehydrogenase isozyme 1; short chain dehydrogenase/reductase family 26C member 1; EC 1.1.1.146
Gene ID : 3290
mRNA Refseq : NM_001206741
Protein Refseq : NP_001193670
MIM : 600713
UniProt ID : P28845

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