idh2
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  • Official Full Name
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial
  • Background
  • Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.
  • Synonyms
  • IDH2; isocitrate dehydrogenase 2 (NADP+), mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial; NADP(+)-specific ICDH; oxalosuccinate decarboxylase; IDH; IDP; IDHM; IDPM; ICD-M; D2HGA2; mNADP-IDH
Cat.#:IDH2-994HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IDH2 Protein, His-tagged
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Cat.#:IDH2-045HTag:MYC/DDK
Source (Host):HEK293 cellSpecies:Human
Product nameRecombinant Human IDH2 Protein, MYC/DDK-tagged
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Cat.#:IDH2-046HTag:DDK
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human IDH2 Protein, DDK-tagged
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Cat.#:IDH2-115HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IDH2(R140K) Protein, His-tagged
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Cat.#:IDH2-116HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IDH2(R140Q) Protein, His-tagged
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Cat.#:IDH2-117HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IDH2(R172Q) Protein, His-tagged
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Cat.#:IDH2-118HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IDH2 Protein, His-tagged
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Cat.#:IDH2-14048HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDH2, GST-tagged
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Cat.#:IDH2-28080THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDH2, His-tagged
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Cat.#:IDH2-7985MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IDH2 Protein
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Cat.#:IDH2-2986RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IDH2 Protein
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Cat.#:IDH2-609CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IDH2 Protein, His-tagged
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Cat.#:IDH2-2192RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IDH2 Protein, His-tagged
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Cat.#:IDH2-3239CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IDH2
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Cat.#:IDH2-9967ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IDH2
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Cat.#:IDH2-5306HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IDH2 293 Cell Lysate
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Involved Pathway

IDH2 involved in several pathways and played different roles in them. We selected most pathways IDH2 participated on our site, such as Citrate cycle (TCA cycle), Glutathione metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Citrate cycle (TCA cycle)
ACO2; IDH3A; PDHA1A; PDHA1B; IDH3B; PDHA2; FH1; ACLYA; FH; SDHDB
Glutathione metabolism
RRM2; GSTO2; GSTAL; GGCT; GSTM5; MGST1.1; MGST2; GPX4B; GSTM4; GSTM2
Metabolic pathways
CYP26A1; ATP5O; ACOX3; CHPF2; NMNAT3; UCK2A; ADI1; NDUFV1; LCLAT1; SYNJ2
Carbon metabolism
ADH5; PDHA1A; GPI; PFKL; GLUD1; GPIB; PGLS; PGAM1B; CAT; PKM2
-Oxocarboxylic acid metabolism
GOT1; ACY1; ACO1; AADAT; BCAT2; GOT2; GPT2L; IDH3A; GPT2; ACO2
Biosynthesis of amino acids
TALDO1; OTC; PKMB; ALDH18A1; SDSL; ASL2; PFKM; GOT2A; PRPS1B; PGAM1
Peroxisome
PRDX1; ACSL4; ACSL1; PEX5L; AMACR; NUDT12; CROT; HMGCLL1; PEX11A; MLYCD

Protein Function

IDH2 has several biochemical functions, for example, NAD binding, isocitrate dehydrogenase (NADP+) activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH2 itself. We selected most functions IDH2 had, and list some proteins which have the same functions with IDH2. You can find most of the proteins on our site.
Function
Related Protein
Function NAD binding
Related Protein GRHPRB; MDH1; IDH3B; PHGDH; HIBADHB; SORD; IDH3A; ADH4; IDH3G; GPD1C
Function isocitrate dehydrogenase (NADP+) activity
Related Protein IDH2; IDH1
Function magnesium ion binding
Related Protein NT5C3B; RPS6KA4; EPHX2; CIB4; ADSS; ABL2; OPA1; NIM1; MTPAP; RRAGC

Interacting Protein

IDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH2.
PYGL; 15-deoxy-delta(12,14; ere_dna; HDAC1; KBTBD7; SIRT4; Mad2l1

IDH2 Related Articles

Kato, Y; et al. Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas. BRAIN TUMOR PATHOLOGY 32:3-11(2015).
Cryan, JB; Haidar, S; et al. Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas. ONCOTARGET 5:8083-8092(2014).