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IDH2

  • Official Full Name

    isocitrate dehydrogenase 2 (NADP+), mitochondrial

  • Overview

    Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.
  • Synonyms

    IDH2; isocitrate dehydrogenase 2 (NADP+), mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial; NADP(+)-specific ICDH; oxalosuccinate decarboxylase; IDH; IDP; IDHM; IDPM; ICD-M; D2HGA2; mNADP-IDH;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • DDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IDH2-14048H Recombinant Human IDH2, GST-tagged E.coli GST 104-452a.a.
Human IDH2-115H Recombinant Human IDH2(R140K) Protein, His-tagged E.coli His 40-452
Human IDH2-045H Recombinant Human IDH2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IDH2-046H Recombinant Human IDH2 Protein, DDK-tagged Insect Cell DDK
Human IDH2-28080TH Recombinant Human IDH2, His-tagged E.coli His
Human IDH2-116H Recombinant Human IDH2(R140Q) Protein, His-tagged E.coli His 40-452
Human IDH2-117H Recombinant Human IDH2(R172Q) Protein, His-tagged E.coli His 40-452
Human IDH2-118H Recombinant Human IDH2 Protein, His-tagged E.coli His 40-452
Human IDH2-5306HCL Recombinant Human IDH2 293 Cell Lysate HEK293 N/A
Human IDH2-119H Recombinant Human IDH2 protein, His-tagged E.coli His Ala40~Gln452
Human IDH2-2835H Recombinant Human IDH2 protein, His-tagged E.coli His 104-452 aa
Human IDH2-1135H Recombinant Human IDH2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IDH2-994H Recombinant Human IDH2 Protein, His-tagged Insect Cell His
Human IDH2-1135H-B Recombinant Human IDH2 Protein Pre-coupled Magnetic Beads HEK293
Human IDH2-1044HFL Recombinant Full Length Human IDH2 Protein, C-Flag-tagged Mammalian cells Flag
Human IDH2-3097H Recombinant Human IDH2 Protein (Met1-Leu414), C-His tagged Mammalian cells C-His Met1-Leu414
Human IDH2-3098H Recombinant Human IDH2 Protein (Ala40-Gln452), N-His tagged E.coli N-His Ala40-Gln452
Mouse IDH2-7985M Recombinant Mouse IDH2 Protein Mammalian Cell His
Mouse Idh2-3472M Recombinant Mouse Idh2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse IDH2-4410M Recombinant Mouse IDH2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse IDH2-4410M-B Recombinant Mouse IDH2 Protein Pre-coupled Magnetic Beads HEK293
Rat IDH2-2986R Recombinant Rat IDH2 Protein Mammalian Cell His
Rat IDH2-2641R-B Recombinant Rat IDH2 Protein Pre-coupled Magnetic Beads HEK293
Rat IDH2-2641R Recombinant Rat IDH2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey IDH2-609C Recombinant Cynomolgus IDH2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey IDH2-355C Recombinant Cynomolgus Monkey IDH2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey IDH2-355C-B Recombinant Cynomolgus Monkey IDH2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IDH2-2192R Recombinant Rhesus monkey IDH2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IDH2-2013R-B Recombinant Rhesus Macaque IDH2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IDH2-2013R Recombinant Rhesus Macaque IDH2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish IDH2-9967Z Recombinant Zebrafish IDH2 Mammalian Cell His
Chicken IDH2-3239C Recombinant Chicken IDH2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IDH2 Related Articles
  • IDH2 Related Research Area

IDH2 involved in several pathways and played different roles in them. We selected most pathways IDH2 participated on our site, such as Citrate cycle (TCA cycle), Glutathione metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Citrate cycle (TCA cycle)IDH3G;SUCLA2;PDHB;PCXB;PDHA1B;ACLYA;PCK1;DLST;DLAT
Glutathione metabolismGSTT1B;GPX1;GSTM1;GPX7;OPLAH;ANPEP;MGST1;MGST1.1;ODC1
Metabolic pathwaysGALNT18A;PYCR1B;GLCEA;HMGCLL1;G6PC3;DNMT4;CYP2C55;HOGA1;PLA2G4C
Carbon metabolismTKTL1;PGAM1B;GLDC;DLDH;PDHA1;PCCB;SDHDB;SHMT2;GLUD1B
-Oxocarboxylic acid metabolismACO2;ACO1;ACY1;GOT2B;GOT1;BCAT1;GOT2A;GPT;AADAT
Biosynthesis of amino acidsPKMB;TKTL1;PC;ALDOC;GPT;PCXB;ALDOAA;ENO1A;PKM
PeroxisomeBAAT;ABCD1;PEX3;FAR1;NOS2;CRATB;AGXTA;AMACR;NUDT19

IDH2 has several biochemical functions, for example, NAD binding, isocitrate dehydrogenase (NADP+) activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH2 itself. We selected most functions IDH2 had, and list some proteins which have the same functions with IDH2. You can find most of the proteins on our site.

Function Related Protein
NAD bindingCTBP2L;AOX1;HIBADHA;ADH1;HPGD;DLD;LDHA;AHCY;IDH3G
isocitrate dehydrogenase (NADP+) activityIDH1;IDH2
magnesium ion bindingHMGCL;TOP2A;RPS6KAL;ALPP;ZAK;PTENA;MTHFD2;NME1;PSPH

IDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH2.

PYGL; 15-deoxy-delta(12,14; ere_dna; HDAC1; KBTBD7; SIRT4; Mad2l1

Kato, Y; et al. Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas. BRAIN TUMOR PATHOLOGY 32:3-11(2015).
Cryan, JB; Haidar, S; et al. Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas. ONCOTARGET 5:8083-8092(2014).
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