"IDH2" Related Products

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Recombinant Human IDH2 Protein, DDK-tagged

Cat.No. : IDH2-046H
Product Overview : Purified recombinant protein of Homo sapiens isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2) and mutant(R172K) heterodimer, with C-terminal 6xHis and DDK tags, expressed in sf9 cells.
Description : Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
Source : Insect cell
Species : Human
Tag : DDK
Molecular Mass : 46.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 µg/mL as determined by microplate BCA method
Storage Buffer : 50mM Tris-HCl, pH 8.0, 100mM glycine, 150mM NaCl, 10% glycerol.
Gene Name : IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial [ Homo sapiens ]
Official Symbol : IDH2
Synonyms : IDH2; isocitrate dehydrogenase 2 (NADP+), mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial; NADP(+)-specific ICDH; oxalosuccinate decarboxylase; IDH; IDP; IDHM; IDPM; ICD-M; D2HGA2; mNADP-IDH;
Gene ID : 3418
mRNA Refseq : NM_002168
Protein Refseq : NP_002159
MIM : 147650
UniProt ID : P48735

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