Recombinant Human IDH2 Protein, His-tagged IDH2-994H

Cat.No.:	IDH2-994H
Product Overview:	Recombinant human IDH2 protein, fused to His tag at N-terminus, was expressed in Insect cell.
Description:	Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
Source:	Insect cells
Species:	Human
Tag :	His
Form:	50 mM Tris.HCl pH 8.0 , 150 mM NaCl, 10 % glycerol. Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Molecular Mass:	46.6 kDa
Purity:	>50 ug/mL as determined by microplate BCA method
Concentration:	>50 ug/mL as determined by microplate BCA method

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Gene Name:	IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial [ Homo sapiens ]
Official Symbol:	IDH2
Synonyms:	D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; mNADP-IDH
Gene ID:	3418
mRNA Refseq:	NM_002168
Protein Refseq:	NP_002159
MIM:	147650
UniProt ID:	P48735