Recombinant Human IL17RA Protein (Met1-Trp320), His-tagged, Biotinylated
| Cat.No. : | IL17RA-450H |
| Product Overview : | Recombinant Human IL17RA Protein (NP_055154.3) (Met1-Trp320) was produced by HEK293 Cells expression system. This protein was expressed with a C-terminal polyhistidine tag. The purified protein was biotinylated in vitro. |
- Specification
- Gene Information
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| Description : | Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | His |
| Predicted N Terminal : | Leu 33 |
| Form : | Lyophilized from sterile Sterile PBS. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
| Molecular Mass : | The recombinant IL17RA consists of 299 amino acids and predicts a molecular mass of 34.9 kDa. |
| Protein length : | Met1-Trp320 |
| Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
| Purity : | > 95 % as determined by SDS-PAGE. |
| Stability : | Samples are stable for up to twelve months from date of receipt at -70 centigrade. |
| Storage : | Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
| Shipping : | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
| Gene Name : | IL17RA interleukin 17 receptor A [ Homo sapiens ] |
| Official Symbol : | IL17RA |
| Synonyms : | IL17RA; CD217; CDw217; hIL 17R; IL 17RA; IL-17 receptor A; IL17R; CANDF5; IL-17RA; hIL-17R; FLJ32274; FLJ36453; MGC10262; |
| Gene ID : | 23765 |
| mRNA Refseq : | NM_014339 |
| Protein Refseq : | NP_055154 |
| MIM : | 605461 |
| UniProt ID : | Q96F46 |
Products Types
| ◆ Recombinant Protein | ||
| IL17RA-153H | Recombinant Active Human IL17RA Protein (ECD), His-tagged(C-ter) | +Inquiry |
| IL17RA-449H | Recombinant Human IL17RA Protein (Met1-Trp320), His-Fc-tagged, Biotinylated | +Inquiry |
| Il17ra-1240M | Recombinant Mouse Il17ra Protein, MYC/DDK-tagged | +Inquiry |
| IL17RA-442R | Recombinant Rhesus IL17RA Protein, His-tagged | +Inquiry |
| IL17RA-1167H | Recombinant Human IL17RA Protein, His (Fc)-Avi-tagged | +Inquiry |
| ◆ Lysates | ||
| IL17RA-2640HCL | Recombinant Human IL17RA cell lysate | +Inquiry |
| IL17RA-1070MCL | Recombinant Mouse IL17RA cell lysate | +Inquiry |
| IL17RA-1441RCL | Recombinant Rat IL17RA cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionSurface plasmon resonance, co-immunoprecipitation, and mutagenesis studies reveal IL17RA's binding partners and affinity.
Cross-pathway signaling assays, gene expression profiling, and functional rescue experiments unveil IL17RA's interaction networks.
Angiogenesis assays, fibroblast activation assays, and tissue remodeling models illuminate IL17RA's role in tissue repair.
Animal models, pharmacological interventions, and toxicity assessments evaluate IL17RA-targeted therapies and translational challenges.
Patient cohorts, clinical data analysis, and immune profiling provide insights into IL17RA's relevance in autoimmune diseases.
Flow cytometry, in vivo imaging, and chemotaxis assays characterize immune cell responses guided by IL17RA activation.
Phosphorylation assays, gene expression analysis, and knockout models dissect IL17RA-mediated signaling cascades.
Disease models, antibody-based treatments, and inflammatory biomarker assessments elucidate IL17RA's therapeutic potential.
ChIP-sequencing, promoter analysis, and epigenetic modification studies uncover IL17RA gene regulation mechanisms.
Epithelial barrier assays, microbiome analysis, and infection models decipher IL17RA's role in mucosal defense.
Customer Reviews (3)
Write a reviewEffective in T-cell activation. -
Suitable for co-immunoprecipitation. -
High solubility. -
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