Recombinant Human IL17RA Protein, His-tagged
|Product Overview :||Recombinant Human IL17RA Protein with His tag was expressed in E. coli.|
- Gene Information
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|Description :||The IL-17 family of cytokines consists of IL-17A-F, and their receptors include IL-17RA-RE. IL-17 cytokines are produced by a variety of cell types including the Th17 subset of CD4+ T cells, as well as subsets of γδ T cells, NK cells, and NKT cells. IL-17A and IL-17F, the most well-studied of the IL-17 cytokines, contribute to fungal and bacterial immunity by inducing expression of proinflammatory cytokines, chemokines, and antimicrobial peptides. In addition, IL-17A contributes to the pathogenesis of several autoimmune disease. IL-17E promotes Th2 cell responses. The roles of IL-17B, IL-17C, and IL-17D are less clear, however these family members also appear to have the capacity to induce proinflammatory cytokines. IL-17 receptors have an extracellular domain, a transmembrane domain, and a SEFIR domain. They are believed to signal as homodimers, heterodimers, or multimers through their SEFIR domain by recruiting the SEFIR domain-containing adaptor Act1. Unlike most cytokines that signal through Jak/STAT pathways, IL-17 signaling results in NF-κB activation. IL-17RA associates with IL-17RC to mediate signaling by homodimers and heterodimers of IL-17A and IL-17. IL-17RA is broadly expressed with highest expression in hematopoietic cells.|
|Source :||E. coli|
|Molecular Mass :||~37 kDa|
|AA Sequence :||MLRLLDHRALVCSQPGLNCTVKNST CLDDSWIHPRNLTPSSPKDLQIQLH FAHTQQGDLFPVAHIEWTLQTDASI LYLEGAELSVLQLNTNERLCVRFEF LSKLRHHHRRWRFTFSHFVVDPDQE YEVTVHHLPKPIPDGDPNHQSKNFL VPDCEHARMKVTTPCMSSGSLWDPN ITVETLEAHQLRVSFTLWNESTHYQ ILLTSFPHMENHSCFEHMHHIPAPR PEEFHQRSNVTLTLRNLKGCCRHQV QIQPFFSSCLNDCLRHSATVSCPEM PDTPEPIPDYMPLW|
|Purity :||Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).|
|Notes :||For research use only, not for use in diagnostic procedure.|
|Storage :||Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.|
|Storage Buffer :||PBS, 4M Urea, pH7.4|
|Gene Name :||IL17RA interleukin 17 receptor A [ Homo sapiens (human) ]|
|Official Symbol :||IL17RA|
|Synonyms :||IL17RA; interleukin 17 receptor A; IL17R, interleukin 17 receptor; interleukin-17 receptor A; CD217; CDw217; hIL 17R; IL 17RA; IL-17 receptor A; IL17R; CANDF5; IL-17RA; hIL-17R; FLJ32274; FLJ36453; MGC10262;|
|Gene ID :||23765|
|mRNA Refseq :||NM_014339|
|Protein Refseq :||NP_055154|
|UniProt ID :||Q96F46|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Surface plasmon resonance, co-immunoprecipitation, and mutagenesis studies reveal IL17RA's binding partners and affinity.
Cross-pathway signaling assays, gene expression profiling, and functional rescue experiments unveil IL17RA's interaction networks.
Angiogenesis assays, fibroblast activation assays, and tissue remodeling models illuminate IL17RA's role in tissue repair.
Animal models, pharmacological interventions, and toxicity assessments evaluate IL17RA-targeted therapies and translational challenges.
Patient cohorts, clinical data analysis, and immune profiling provide insights into IL17RA's relevance in autoimmune diseases.
Flow cytometry, in vivo imaging, and chemotaxis assays characterize immune cell responses guided by IL17RA activation.
Phosphorylation assays, gene expression analysis, and knockout models dissect IL17RA-mediated signaling cascades.
Disease models, antibody-based treatments, and inflammatory biomarker assessments elucidate IL17RA's therapeutic potential.
ChIP-sequencing, promoter analysis, and epigenetic modification studies uncover IL17RA gene regulation mechanisms.
Epithelial barrier assays, microbiome analysis, and infection models decipher IL17RA's role in mucosal defense.
Customer Reviews (3)Write a review
Effective in T-cell activation. -
Suitable for co-immunoprecipitation. -
High solubility. -
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