Rabbit Anti-Human Interleukin 17 Receptor A Monoclonal Antibody

Cat.No. : CAB11561RH
Product Overview : Rabbit Monoclonal Antibody to Human Interleukin 17 Receptor A
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Antigen Description : IL17RA ( Interleukin 17 receptor A ), also known as IL17R and CDw217, is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A (IL17A). IL17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL17A binds to a type I cell surface receptor called IL17R of which there are at least three variants IL17RA, IL17RB, and IL17RC. IL17RA is a widely expressed glycoprotein that plays a central role in inflammatory responses. IL17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. Human IL17RA is an 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy-proximal transmembrane domain, and a 525 aa cytoplasmic tail. The aa sequence of human IL17RA is 69% identical to the mouse IL17R. Within the extracellular domain, human IL17RA shares 72% aa sequence identity with mouse and rat IL17RA. IL17RA associates with IL17RC to form a signaling receptor complex for IL17 and IL17F. Ligand and IL17RA ligation promotes T cell activation and the production of IL-6, G-CSF, SCF, and multiple proinflammatory chemokines.
Specificity : Human IL17RA / CD217. No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA.
Immunogen : Recombinant human IL17RA protein
Host : Rabbit
Isotype : Rabbit IgG
Species : Human
Cross Reactivity : 012
Clone : A013
Applications : WB; ELISA
Dilution : Western blot: This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect human IL17RAin WB. Using a DAB detection system, the detection limit for human IL17RA is approximately 0.125 ng/lane under non-reducing conditions and reducing conditionsDirect ELISA: This antibody can be used at 0.1 - 0.2 μg/mL with the appropriate secondary reagents to detect human IL17RA. The detection limit for human IL17RA is approximately 0.00245 ng/well
Preparation : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human IL17RA ( rh IL17RA ; NP_055154.3 ; Met 1 - Trp 320 ).
Format : 0.2 μm filtered solution in PBS with 5% trehalose
Storage : This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name : IL17RA interleukin 17 receptor A [ Homo sapiens ]
Official Symbol : IL17RA
Synonyms : IL17RA; interleukin 17 receptor A; IL17R,interleukin 17 receptor; interleukin-17 receptor A; CD217; CDw217; hIL 17R; IL 17RA; IL-17 receptor A; IL17R; CANDF5; IL-17RA; hIL-17R; FLJ32274; FLJ36453; MGC10262;
Gene ID : 23765
mRNA Refseq : NM_014339
Protein Refseq : NP_055154
MIM : 605461
UniProt ID : Q96F46
Chromosome Location : 22q11.1
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : interleukin-17 receptor activity; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What experimental techniques are employed to investigate the interaction between IL17RA and various IL17 family members, and how is their binding specificity determined? 12/02/2022

Surface plasmon resonance, co-immunoprecipitation, and mutagenesis studies reveal IL17RA's binding partners and affinity.

Can you discuss the experimental designs used to examine the crosstalk between IL17RA signaling and other immune pathways, such as TNF-α or IFN-纬 pathways? 11/16/2020

Cross-pathway signaling assays, gene expression profiling, and functional rescue experiments unveil IL17RA's interaction networks.

What strategies are utilized to explore the contribution of IL17RA to tissue remodeling processes, such as angiogenesis and fibrosis? 11/08/2020

Angiogenesis assays, fibroblast activation assays, and tissue remodeling models illuminate IL17RA's role in tissue repair.

How is the potential of IL17RA as a therapeutic target evaluated in experimental settings, and what challenges exist in translating these findings to clinical applications? 03/15/2020

Animal models, pharmacological interventions, and toxicity assessments evaluate IL17RA-targeted therapies and translational challenges.

How do researchers study the involvement of IL17RA in autoimmune disorders through patient samples, and what insights have been gained? 12/26/2019

Patient cohorts, clinical data analysis, and immune profiling provide insights into IL17RA's relevance in autoimmune diseases.

How do researchers study the role of IL17RA in the regulation of immune cell recruitment and infiltration in inflammatory tissues? 12/13/2018

Flow cytometry, in vivo imaging, and chemotaxis assays characterize immune cell responses guided by IL17RA activation.

Can you elaborate on the methods used to dissect the intracellular signaling pathways triggered by IL17RA activation, especially in the context of autoimmune diseases? 04/28/2018

Phosphorylation assays, gene expression analysis, and knockout models dissect IL17RA-mediated signaling cascades.

Could you explain the experimental approaches employed to assess the impact of IL17RA inhibition on chronic inflammatory diseases in preclinical models? 01/10/2018

Disease models, antibody-based treatments, and inflammatory biomarker assessments elucidate IL17RA's therapeutic potential.

What molecular methods are employed to understand the genetic and epigenetic regulation of IL17RA expression in immune cells? 07/22/2017

ChIP-sequencing, promoter analysis, and epigenetic modification studies uncover IL17RA gene regulation mechanisms.

What techniques are used to investigate the role of IL17RA in maintaining epithelial barrier integrity and preventing microbial invasion? 03/06/2017

Epithelial barrier assays, microbiome analysis, and infection models decipher IL17RA's role in mucosal defense.

Customer Reviews (3)

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Reviews
01/23/2021

    Effective in T-cell activation.

    07/12/2019

      Suitable for co-immunoprecipitation.

      03/17/2017

        High solubility.

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