Recombinant Human IL17RA Protein (Met1-Trp320), His-Fc-tagged, Biotinylated

Cat.No. : IL17RA-449H
Product Overview : Recombinant Human IL17RA Protein (NP_055154.3) (Met1-Trp320) was produced by HEK293 Cells expression system. This protein was expressed with the C-terminal polyhistidine-taggged Fc region of human IgG1 at the C-terminus. The purified protein was biotinylated in vitro.
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Description : Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Source : HEK293
Species : Human
Tag : His-Fc
Predicted N Terminal : Leu 33
Form : Lyophilized from sterile Sterile PBS. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant IL17RA consists of 536 amino acids and predicts a molecular mass of 61.6 kDa.
Protein length : Met1-Trp320
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 90 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade.
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name : IL17RA interleukin 17 receptor A [ Homo sapiens ]
Official Symbol : IL17RA
Synonyms : IL17RA; CD217; CDw217; hIL 17R; IL 17RA; IL-17 receptor A; IL17R; CANDF5; IL-17RA; hIL-17R; FLJ32274; FLJ36453; MGC10262;
Gene ID : 23765
mRNA Refseq : NM_014339
Protein Refseq : NP_055154
MIM : 605461
UniProt ID : Q96F46

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
01/23/2021

    Effective in T-cell activation.

    07/12/2019

      Suitable for co-immunoprecipitation.

      03/17/2017

        High solubility.

        Q&As (10)

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        What experimental techniques are employed to investigate the interaction between IL17RA and various IL17 family members, and how is their binding specificity determined? 12/02/2022

        Surface plasmon resonance, co-immunoprecipitation, and mutagenesis studies reveal IL17RA's binding partners and affinity.

        Can you discuss the experimental designs used to examine the crosstalk between IL17RA signaling and other immune pathways, such as TNF-α or IFN-纬 pathways? 11/16/2020

        Cross-pathway signaling assays, gene expression profiling, and functional rescue experiments unveil IL17RA's interaction networks.

        What strategies are utilized to explore the contribution of IL17RA to tissue remodeling processes, such as angiogenesis and fibrosis? 11/08/2020

        Angiogenesis assays, fibroblast activation assays, and tissue remodeling models illuminate IL17RA's role in tissue repair.

        How is the potential of IL17RA as a therapeutic target evaluated in experimental settings, and what challenges exist in translating these findings to clinical applications? 03/15/2020

        Animal models, pharmacological interventions, and toxicity assessments evaluate IL17RA-targeted therapies and translational challenges.

        How do researchers study the involvement of IL17RA in autoimmune disorders through patient samples, and what insights have been gained? 12/26/2019

        Patient cohorts, clinical data analysis, and immune profiling provide insights into IL17RA's relevance in autoimmune diseases.

        How do researchers study the role of IL17RA in the regulation of immune cell recruitment and infiltration in inflammatory tissues? 12/13/2018

        Flow cytometry, in vivo imaging, and chemotaxis assays characterize immune cell responses guided by IL17RA activation.

        Can you elaborate on the methods used to dissect the intracellular signaling pathways triggered by IL17RA activation, especially in the context of autoimmune diseases? 04/28/2018

        Phosphorylation assays, gene expression analysis, and knockout models dissect IL17RA-mediated signaling cascades.

        Could you explain the experimental approaches employed to assess the impact of IL17RA inhibition on chronic inflammatory diseases in preclinical models? 01/10/2018

        Disease models, antibody-based treatments, and inflammatory biomarker assessments elucidate IL17RA's therapeutic potential.

        What molecular methods are employed to understand the genetic and epigenetic regulation of IL17RA expression in immune cells? 07/22/2017

        ChIP-sequencing, promoter analysis, and epigenetic modification studies uncover IL17RA gene regulation mechanisms.

        What techniques are used to investigate the role of IL17RA in maintaining epithelial barrier integrity and preventing microbial invasion? 03/06/2017

        Epithelial barrier assays, microbiome analysis, and infection models decipher IL17RA's role in mucosal defense.

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