Recombinant Full Length Human IL17RA Protein, C-Flag-tagged

• Cat.No.: IL17RA-2083HFL
• Product Overview: Recombinant Full Length Human IL17RA Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 93.2 kDa
• AA Sequence: MGAARSPPSAVPGPLLGLLLLLLGV LAPGGASLRLLDHRALVCSQPGLNC TVKNSTCLDDSWIHPRNLTP SSPKDLQIQLHFAHTQQGDLFPVAH IEWTLQTDASILYLEGAELSVLQLN TNERLCVRFEFLSKLRHHHR RWRFTFSHFVVDPDQEYEVTVHHLP KPIPDGDPNHQSKNFLVPDCEHARM KVTTPCMSSGSLWDPNITVE TLEAHQLRVSFTLWNESTHYQILLT SFPHMENHSCFEHMHHIPAPRPEEF HQRSNVTLTLRNLKGCCRHQ VQIQPFFSSCLNDCLRHSATVSCPE MPDTPEPIPDYMPLWVYWFITGISI LLVGSVILLIVCMTWRLAGP GSEKYSDDTKYTDGLPVADLIPPPL KPRKVWIIYSADHPLYVDVVLKFAQ FLLTACGTEVALDLLEEQAI SEAGVMTWVGRQKQEMVESNSKIIV LCSRGTRAKWQALLGRGAPVRLRCD HGKPVGDLFTAAMNMILPDF KRPACFGTYVVCYFSEVSCDGDVPD LFGAAPRYPLMDRFEEVYFRIQDLE MFQPGRMHRVGELSGDNYLR SPGGRQLRAALDRFRDWQVHCPDWF ECENLYSADDQDAPSLDEEVFEEPL LPPGTGIVKRAPLVREPGSQ ACLAIDPLVGEEGGAAVAKLEPHLQ PRGQPAPQPLHTLVLAAEEGALVAA VEPGPLADGAAVRLALAGEG EACPLLGSPGAGRNSVLFLPVDPED SPLGSSTPMASPDLLPEDVREHLEG LMLSLFEQSLSCQAQGGCSR PAMVLTDPHTPYEEEQRQSVQSDQG YISRSSPQPPEGLTEMEEEEEEEQD PGKPALPLSPEDLESLRSLQ RQLLFRQLQKNSGWDTMGSESEGPS A TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction

Gene Information

• Gene Name: IL17RA interleukin 17 receptor A [ Homo sapiens (human) ]
• Official Symbol: IL17RA
• Synonyms: CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R
• Gene ID: 23765
• mRNA Refseq: NM_014339.7
• Protein Refseq: NP_055154.3
• MIM: 605461
• UniProt ID: Q96F46