IL17RC
-
Official Full Name
interleukin 17 receptor C -
Overview
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. -
Synonyms
IL17RC;interleukin 17 receptor C;interleukin-17 receptor C;IL17 RL;IL 17 receptor C;IL 17RC;IL 17RL;IL17 receptor C;IL17F receptor;IL17RL;Interleukin 17 receptor homolog;Interleukin 17 receptor like;Interleukin 17 receptor like protein;IL-17RL;IL17Rhom;zcytoR14;IL-17 receptor C;interleukin-17 receptor homolog;interleukin-17 receptor-like protein;IL17-RL
Recombinant Proteins
- Human
- Mouse
- E.coli
- HEK293
- Mammalian Cells
- CHO
- Insect Cells
- Human Cells
- His
- Fc
- Non
- Avi
- DDK
- Myc
Involved Pathway
IL17RC involved in several pathways and played different roles in them. We selected most pathways IL17RC participated on our site, such as IL17 signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL17RC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IL17 signaling pathway | IL17F,IL17RE,IL17C,TRAF3IP2 |
Protein Function
IL17RC has several biochemical functions, for example, interleukin-17 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL17RC itself. We selected most functions IL17RC had, and list some proteins which have the same functions with IL17RC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-17 receptor activity | IL17RA,IL17RE,IL17RB,IL17RD |
Interacting Protein
IL17RC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL17RC here. Most of them are supplied by our site. Hope this information will be useful for your research of IL17RC.
Resources
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References
- Elain, G; Jeanneau, K; et al. The Selective Anti-IL17A Monoclonal Antibody Secukinumab ( AIN457) Attenuates IL17A-Induced Levels of IL6 in Human Astrocytes. GLIA 62:725-735(2014).
- Hecker, M; Paap, BK; et al. Reassessment of Blood Gene Expression Markers for the Prognosis of Relapsing-Remitting Multiple Sclerosis. PLOS ONE 6:-(2011).
