IL17RC
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Official Full Name
interleukin 17 receptor C
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Background
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. -
Synonyms
IL17RC; interleukin 17 receptor C; interleukin-17 receptor C; IL17 RL; IL 17 receptor C; IL 17RC; IL 17RL; IL17 receptor C; IL17F receptor; IL17RL; Interleukin 17 receptor homolog; Interleukin 17 receptor like; Interleukin 17 receptor like protein; IL-17RL; IL17Rhom; zcytoR14; IL-17 receptor C; interleukin-17 receptor homolog; interleukin-17 receptor-like protein; IL17-RL;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL17RC Related Articles
- IL17RC Related Gene Family
- IL17RC Related Research Area
IL17RC involved in several pathways and played different roles in them. We selected most pathways IL17RC participated on our site, such as IL17 signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL17RC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IL17 signaling pathway | IL17C;IL17F;IL17RC;IL17RE;TRAF3IP2 |
IL17RC has several biochemical functions, for example, interleukin-17 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL17RC itself. We selected most functions IL17RC had, and list some proteins which have the same functions with IL17RC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-17 receptor activity | IL17RE;IL17RC;IL17RB;IL17RA;IL17RD |
IL17RC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL17RC here. Most of them are supplied by our site. Hope this information will be useful for your research of IL17RC.
- Q&As
- Reviews
Q&As (10)
Ask a questionCo-stimulation assays, co-immunoprecipitation, and gene expression analysis reveal IL17RC's interplay with other immune pathways.
Structural studies provide insights into IL17RC's binding interface with ligands, aiding in understanding cytokine-receptor interactions.
In vitro cell migration assays, cytokine profiling, and adoptive transfer experiments investigate IL17RC's impact on immune cell functions.
Animal models, patient-derived cells, and genetic association studies explore IL17RC's involvement in autoimmune disorders.
Conditional knockout models, adoptive transfer experiments, and tissue-specific inflammation assays unveil IL17RC's role in disease contexts.
Biomarker analysis, patient stratification, and correlation studies validate the clinical relevance of IL17RC in human diseases.
Preclinical models, therapeutic antibodies, and disease amelioration studies assess IL17RC as a target for immune-mediated disorders.
Phosphorylation assays, reporter gene assays, and CRISPR screens dissect IL17RC-mediated signaling events and immune outcomes.
Immunofluorescence, flow cytometry, and single-cell RNA sequencing determine IL17RC expression profiles in diverse cell populations.
Perturbation studies, siRNA knockdown, and gene editing differentiate IL17RC's roles in distinct IL17 cytokine pathways.
Customer Reviews (3)
Write a reviewHigh purity. -
Suitable for signaling studies. -
Effective in neutrophil activation. -
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