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  • Official Full Name

    interleukin 17 receptor C

  • Overview

    This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
  • Synonyms

    IL17RC; interleukin 17 receptor C; interleukin-17 receptor C; IL17 RL; IL 17 receptor C; IL 17RC; IL 17RL; IL17 receptor C; IL17F receptor; IL17RL; Interleukin 17 receptor homolog; Interleukin 17 receptor like; Interleukin 17 receptor like protein; IL-17RL; IL17Rhom; zcytoR14; IL-17 receptor C; interleukin-17 receptor homolog; interleukin-17 receptor-like protein; IL17-RL;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Insect Cells
  • Mammalian cells
  • Fc
  • Avi
  • His
  • His (Fc)
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL17RC-423H Active Recombinant Human IL17RC Protein, Fc-tagged HEK293 Fc
Human IL17RC-645H Active Recombinant Human Interleukin 17 Receptor C, HIgG1 Fc-tagged CHO Fc
Human IL17RC-786H Active Recombinant Human IL17RC Protein, His-tagged Mammalian cells His Leu21-Ala454
Human IL17RC-641H Active Recombinant Human Interleukin 17 Receptor C, HIgG1 Fc-tagged, mutant CHO Fc
Human IL17RC-249H Active Recombinant Human IL17RC protein, Fc-tagged HEK293 Fc
Human IL17RC-14159H Recombinant Human IL17RC, His-tagged E.coli His 1-350a.a.
Human IL17RC-596H Recombinant Human IL17RC protein, His-tagged E.coli His Asn257~Asn477
Human IL17RC-741H Active Recombinant Human IL17RC protein, His-tagged Insect Cells His Met1-Ala454
Human IL17RC-494HCL Recombinant Human IL17RC cell lysate Insect Cell N/A
Human IL17RC-1611HCL Recombinant Human IL17RC cell lysate Human Cell N/A
Human IL17RC-1865H Active Recombinant Human IL17RC protein, Fc & Avi-tagged, Biotinylated HEK293 Fc/Avi Leu 21 - His 465
Human IL17RC-3559H Recombinant Human IL17RC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL17RC-3144H Recombinant Human IL17RC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL17RC-3144H-B Recombinant Human IL17RC Protein Pre-coupled Magnetic Beads HEK293
Human IL17RC-2909H Recombinant Human IL17RC Protein (Asn257-Asn477), N-His tagged E.coli N-His Asn257-Asn477
Mouse Il17rc-5648M Active Recombinant Mouse Interleukin 17 receptor C, His-tagged Mammalian cells His
Mouse Il17rc-294M Active Recombinant Mouse Il17rc, His-tagged Mammalian cells His
Mouse Il17rc-7986M Recombinant Mouse Il17rc protein, His-tagged E.coli His Arg73-Phe330 (Accession # Q8K4C2)
Mouse Il17rc-3501M Recombinant Mouse Il17rc Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Il17rc-4496M Recombinant Mouse Il17rc Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Il17rc-4496M-B Recombinant Mouse Il17rc Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IL17RC Related Articles
  • IL17RC Related Gene Family
  • IL17RC Related Research Area

IL17RC involved in several pathways and played different roles in them. We selected most pathways IL17RC participated on our site, such as IL17 signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL17RC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
IL17 signaling pathwayTRAF3IP2;IL17F;IL17RE;IL17RC;IL17C

IL17RC has several biochemical functions, for example, interleukin-17 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL17RC itself. We selected most functions IL17RC had, and list some proteins which have the same functions with IL17RC. You can find most of the proteins on our site.

Function Related Protein
interleukin-17 receptor activityIL17RC;IL17RD;IL17RA;IL17RB;IL17RE

IL17RC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL17RC here. Most of them are supplied by our site. Hope this information will be useful for your research of IL17RC.

Elain, G; Jeanneau, K; et al. The Selective Anti-IL17A Monoclonal Antibody Secukinumab ( AIN457) Attenuates IL17A-Induced Levels of IL6 in Human Astrocytes. GLIA 62:725-735(2014).
Hecker, M; Paap, BK; et al. Reassessment of Blood Gene Expression Markers for the Prognosis of Relapsing-Remitting Multiple Sclerosis. PLOS ONE 6:-(2011).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
What experimental strategies are employed to investigate the crosstalk between IL17RC and other immune receptors or cytokine pathways? 06/15/2022

Co-stimulation assays, co-immunoprecipitation, and gene expression analysis reveal IL17RC's interplay with other immune pathways.

How are structural biology approaches, such as X-ray crystallography or cryo-electron microscopy, used to understand IL17RC's interaction with its ligands? 02/02/2022

Structural studies provide insights into IL17RC's binding interface with ligands, aiding in understanding cytokine-receptor interactions.

What methodologies are used to assess the impact of IL17RC inhibition on immune cell differentiation, migration, and cytokine production? 08/11/2021

In vitro cell migration assays, cytokine profiling, and adoptive transfer experiments investigate IL17RC's impact on immune cell functions.

Can you elaborate on the methods used to investigate IL17RC's contribution to autoimmune diseases, considering its involvement in IL17-mediated inflammation? 04/15/2021

Animal models, patient-derived cells, and genetic association studies explore IL17RC's involvement in autoimmune disorders.

Could you explain how genetic and pharmacological manipulation of IL17RC expression or function in animal models helps elucidate its role in tissue-specific inflammation? 05/26/2020

Conditional knockout models, adoptive transfer experiments, and tissue-specific inflammation assays unveil IL17RC's role in disease contexts.

How are patient-derived samples and clinical data integrated into experimental research to investigate the relevance of IL17RC in human diseases? 11/23/2019

Biomarker analysis, patient stratification, and correlation studies validate the clinical relevance of IL17RC in human diseases.

How do researchers study the potential of targeting IL17RC as a therapeutic strategy in inflammatory and autoimmune conditions? 05/04/2018

Preclinical models, therapeutic antibodies, and disease amelioration studies assess IL17RC as a target for immune-mediated disorders.

What cellular and molecular assays are utilized to unravel the downstream signaling cascades triggered by IL17RC activation and their impact on immune responses? 11/23/2017

Phosphorylation assays, reporter gene assays, and CRISPR screens dissect IL17RC-mediated signaling events and immune outcomes.

What experimental techniques are employed to study the expression and localization of IL17RC in different immune and non-immune cell types? 09/29/2017

Immunofluorescence, flow cytometry, and single-cell RNA sequencing determine IL17RC expression profiles in diverse cell populations.

How do researchers experimentally distinguish the roles of IL17RC in specific IL17 cytokine signaling pathways? 07/06/2017

Perturbation studies, siRNA knockdown, and gene editing differentiate IL17RC's roles in distinct IL17 cytokine pathways.

Customer Reviews (3)

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    High purity.


      Suitable for signaling studies.


        Effective in neutrophil activation.

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