Active Recombinant Human Interleukin 17 Receptor C, HIgG1 Fc-tagged
|Product Overview :||The extracellular domain of human IL-17RC (NP_116121.2)(Leu21-Ala454) is fused to the N-terminus of the Fc region of a human IgG1 was expressed in CHO cell.|
- Gene Information
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|Description :||This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.|
|Source :||CHO cell|
|Tag :||HIgG1 Fc-tagged|
|Form :||Lyophilized from 0.2μm-filtered solution in PBS.|
|Bio-activity :||Measured by its ability to bind rhIL-17 in a functional ELISA.|
|Molecular Mass :||74KDa (monomer)|
|AA Sequence :||Leu21-Ala454|
|Endotoxin :||<0.06 eu/μg as determined by lal>0.06>|
|Purity :||>98%, by SDS-PAGE under reducing conditions.|
|Stability :||Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.|
|Reconstitution :||Reconstitute at 100μg/ml in sterile PBS.|
|Warning :||Avoid freeze/thaw cycles.|
|Gene Name :||IL17RC interleukin 17 receptor C [ Homo sapiens ]|
|Official Symbol :||IL17RC|
|Synonyms :||IL17RC; interleukin 17 receptor C; interleukin-17 receptor C; IL17 RL; IL-17RL; IL17Rhom; zcytoR14; IL17F receptor; IL-17 receptor C; interleukin-17 receptor homolog; interleukin-17 receptor-like protein; IL17RL; IL17-RL; FLJ95963; FLJ96005; MGC10763;|
|Gene ID :||84818|
|mRNA Refseq :||NM_001203263|
|Protein Refseq :||NP_001190192|
|UniProt ID :||Q8NAC3|
|Chromosome Location :||3p25.3|
|Function :||receptor activity;|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Co-stimulation assays, co-immunoprecipitation, and gene expression analysis reveal IL17RC's interplay with other immune pathways.
Structural studies provide insights into IL17RC's binding interface with ligands, aiding in understanding cytokine-receptor interactions.
In vitro cell migration assays, cytokine profiling, and adoptive transfer experiments investigate IL17RC's impact on immune cell functions.
Animal models, patient-derived cells, and genetic association studies explore IL17RC's involvement in autoimmune disorders.
Conditional knockout models, adoptive transfer experiments, and tissue-specific inflammation assays unveil IL17RC's role in disease contexts.
Biomarker analysis, patient stratification, and correlation studies validate the clinical relevance of IL17RC in human diseases.
Preclinical models, therapeutic antibodies, and disease amelioration studies assess IL17RC as a target for immune-mediated disorders.
Phosphorylation assays, reporter gene assays, and CRISPR screens dissect IL17RC-mediated signaling events and immune outcomes.
Immunofluorescence, flow cytometry, and single-cell RNA sequencing determine IL17RC expression profiles in diverse cell populations.
Perturbation studies, siRNA knockdown, and gene editing differentiate IL17RC's roles in distinct IL17 cytokine pathways.
Customer Reviews (3)Write a review
High purity. -
Suitable for signaling studies. -
Effective in neutrophil activation. -
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