Active Recombinant Human IL17RC protein, His-tagged

Cat.No. : IL17RC-741H
Product Overview : Recombinant Human IL17RC protein(NP_116121.2)(Met1-Ala454), fused with His tag, was expressed in Insect Cells.
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Source : Insect Cells
Species : Human
Tag : His
Form : Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bio-activity : 1. Measured by its ability to bind with recombinant human IL17A-His in a functional ELISA. 2. Measured by its ability to bind with recombinant human 17A in a functional ELISA.
Molecular Mass : The recombinant human IL17RC (aa 1-454) consists of 444 amino acids and predicts a molecular mass of 49.6 kDa. The apparent molecular mass of the protein is approximately 60 kDa in SDS-PAGE under reducing conditions.
Protein Length : Met1-Ala454
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 90 % as determined by SDS-PAGE
Storage : Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : IL17RC interleukin 17 receptor C [ Homo sapiens ]
Official Symbol : IL17RC
Synonyms : IL17RC; interleukin 17 receptor C; interleukin-17 receptor C; IL17 RL; IL-17RL; IL17Rhom; zcytoR14; IL17F receptor; IL-17 receptor C; interleukin-17 receptor homolog; interleukin-17 receptor-like protein; IL17RL; IL17-RL; FLJ95963; FLJ96005; MGC10763;
Gene ID : 84818
mRNA Refseq : NM_001203263
Protein Refseq : NP_001190192
MIM : 610925
UniProt ID : Q8NAC3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
12/11/2022

    High purity.

    06/19/2022

      Suitable for signaling studies.

      06/11/2021

        Effective in neutrophil activation.

        Q&As (10)

        Ask a question
        What experimental strategies are employed to investigate the crosstalk between IL17RC and other immune receptors or cytokine pathways? 06/15/2022

        Co-stimulation assays, co-immunoprecipitation, and gene expression analysis reveal IL17RC's interplay with other immune pathways.

        How are structural biology approaches, such as X-ray crystallography or cryo-electron microscopy, used to understand IL17RC's interaction with its ligands? 02/02/2022

        Structural studies provide insights into IL17RC's binding interface with ligands, aiding in understanding cytokine-receptor interactions.

        What methodologies are used to assess the impact of IL17RC inhibition on immune cell differentiation, migration, and cytokine production? 08/11/2021

        In vitro cell migration assays, cytokine profiling, and adoptive transfer experiments investigate IL17RC's impact on immune cell functions.

        Can you elaborate on the methods used to investigate IL17RC's contribution to autoimmune diseases, considering its involvement in IL17-mediated inflammation? 04/15/2021

        Animal models, patient-derived cells, and genetic association studies explore IL17RC's involvement in autoimmune disorders.

        Could you explain how genetic and pharmacological manipulation of IL17RC expression or function in animal models helps elucidate its role in tissue-specific inflammation? 05/26/2020

        Conditional knockout models, adoptive transfer experiments, and tissue-specific inflammation assays unveil IL17RC's role in disease contexts.

        How are patient-derived samples and clinical data integrated into experimental research to investigate the relevance of IL17RC in human diseases? 11/23/2019

        Biomarker analysis, patient stratification, and correlation studies validate the clinical relevance of IL17RC in human diseases.

        How do researchers study the potential of targeting IL17RC as a therapeutic strategy in inflammatory and autoimmune conditions? 05/04/2018

        Preclinical models, therapeutic antibodies, and disease amelioration studies assess IL17RC as a target for immune-mediated disorders.

        What cellular and molecular assays are utilized to unravel the downstream signaling cascades triggered by IL17RC activation and their impact on immune responses? 11/23/2017

        Phosphorylation assays, reporter gene assays, and CRISPR screens dissect IL17RC-mediated signaling events and immune outcomes.

        What experimental techniques are employed to study the expression and localization of IL17RC in different immune and non-immune cell types? 09/29/2017

        Immunofluorescence, flow cytometry, and single-cell RNA sequencing determine IL17RC expression profiles in diverse cell populations.

        How do researchers experimentally distinguish the roles of IL17RC in specific IL17 cytokine signaling pathways? 07/06/2017

        Perturbation studies, siRNA knockdown, and gene editing differentiate IL17RC's roles in distinct IL17 cytokine pathways.

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