Recombinant Mouse Il17rc Protein, Myc/DDK-tagged
|Product Overview :||Purified recombinant protein of mouse full-length interleukin 17 receptor C (Il17rc), with C-terminal MYC/DDK tag, expressed in HEK293T cells.|
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|Description :||Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA. Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA. Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway. Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression. Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Primarily induces neutrophil activation and recruitment at infection and inflammatory sites. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers.|
|Molecular Mass :||74.8 kDa|
|Purity :||> 80% as determined by SDS-PAGE and Coomassie blue staining|
|Stability :||Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.|
|Storage :||Store at -80 centigrade after receiving vials.|
|Concentration :||>50 μg/mL as determined by microplate BCA method|
|Storage Buffer :||25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.|
|Gene Name :||Il17rc interleukin 17 receptor C [ Mus musculus (house mouse) ]|
|Official Symbol :||Il17rc|
|Synonyms :||IL17RC; interleukin 17 receptor C; interleukin-17 receptor C; IL-17RL; zcytoR14; IL-17 receptor C; interleukin-17 receptor-like protein; Il17rl; IL-17RC; IL17-RC; IL17-RL; 1110025H02Rik|
|Gene ID :||171095|
|mRNA Refseq :||NM_134159|
|Protein Refseq :||NP_598920|
|UniProt ID :||Q8K4C2|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Co-stimulation assays, co-immunoprecipitation, and gene expression analysis reveal IL17RC's interplay with other immune pathways.
Structural studies provide insights into IL17RC's binding interface with ligands, aiding in understanding cytokine-receptor interactions.
In vitro cell migration assays, cytokine profiling, and adoptive transfer experiments investigate IL17RC's impact on immune cell functions.
Animal models, patient-derived cells, and genetic association studies explore IL17RC's involvement in autoimmune disorders.
Conditional knockout models, adoptive transfer experiments, and tissue-specific inflammation assays unveil IL17RC's role in disease contexts.
Biomarker analysis, patient stratification, and correlation studies validate the clinical relevance of IL17RC in human diseases.
Preclinical models, therapeutic antibodies, and disease amelioration studies assess IL17RC as a target for immune-mediated disorders.
Phosphorylation assays, reporter gene assays, and CRISPR screens dissect IL17RC-mediated signaling events and immune outcomes.
Immunofluorescence, flow cytometry, and single-cell RNA sequencing determine IL17RC expression profiles in diverse cell populations.
Perturbation studies, siRNA knockdown, and gene editing differentiate IL17RC's roles in distinct IL17 cytokine pathways.
Customer Reviews (3)Write a review
High purity. -
Suitable for signaling studies. -
Effective in neutrophil activation. -
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