Active Recombinant Human IL17RC protein, Fc-tagged
|Product Overview :||Recombinant Human IL17RC(Leu21-His465) fused Fc region of Human IgG1 at C-terminal was expressed in HEK293.|
- Gene Information
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|Description :||IL-17 receptor C (IL-17RC; also known as IL-17RL and IL-17Rhom) is an 85-110 kDa member of the IL-17 receptor family. IL-17 plays a key role in the development of autoimmunity and inflammation. Human IL-17 RC is a type I transmembrane glycoprotein that is expressed on neutrophils, endothelial cells, chondrocytes and osteoblasts, breast and prostatic epithelium, fibroblasts, renal tubular epithelium, and skeletal muscle cells. Mature human IL-17 RC consists of a 518 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 232 aa cytoplasmic region. It is estimated that there are over 90 alternative splice forms, with transmembrane-containing isoforms predominating. This recombinant protein corresponds to IL-17 RC isoform 1, the canonical form. Within the ECD, IL-17 RC isoform 1 shares 69% aa sequence identity with mouse IL-17 RC. IL-17 RC is the cognate receptor for IL-17F, and it binds IL-17A with similar affinity. IL-17 RC associates wiith IL-17 RA to form a receptor complex for both IL-17A and IL-17F.|
|Predicted N Terminal :||Leu21|
|Form :||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Bio-activity :||Measured by its binding ability in a functional ELISA. When Recombinant Human IL-17RC Isoform 1 Fc Chimera is coated at 0.5 µg/mL, Recombinant Human IL-17/IL-17A binds with an ED50 = 0.1-0.6 ng/mL.|
|Molecular Mass :||Predicted Molecular Mass: 76 kDa
SDS-PAGE: 95-113 kDa, reducing conditions
|Endotoxin :||<0.1 EU per 1 μg of the protein by the LAL method.|
|Purity :||>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.|
|Storage :||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
|Reconstitution :||Reconstitute at 500 μg/mL in PBS.|
|Gene Name :||IL17RC interleukin 17 receptor C [ Homo sapiens ]|
|Official Symbol :||IL17RC|
|Synonyms :||IL17RC; interleukin 17 receptor C; interleukin-17 receptor C; IL17 RL; IL-17RL; IL17Rhom; zcytoR14; IL17F receptor; IL-17 receptor C; interleukin-17 receptor homolog; interleukin-17 receptor-like protein; IL17RL; IL17-RL; FLJ95963; FLJ96005; MGC10763;|
|Gene ID :||84818|
|mRNA Refseq :||NM_001203263|
|Protein Refseq :||NP_001190192|
|UniProt ID :||Q8NAC3|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Co-stimulation assays, co-immunoprecipitation, and gene expression analysis reveal IL17RC's interplay with other immune pathways.
Structural studies provide insights into IL17RC's binding interface with ligands, aiding in understanding cytokine-receptor interactions.
In vitro cell migration assays, cytokine profiling, and adoptive transfer experiments investigate IL17RC's impact on immune cell functions.
Animal models, patient-derived cells, and genetic association studies explore IL17RC's involvement in autoimmune disorders.
Conditional knockout models, adoptive transfer experiments, and tissue-specific inflammation assays unveil IL17RC's role in disease contexts.
Biomarker analysis, patient stratification, and correlation studies validate the clinical relevance of IL17RC in human diseases.
Preclinical models, therapeutic antibodies, and disease amelioration studies assess IL17RC as a target for immune-mediated disorders.
Phosphorylation assays, reporter gene assays, and CRISPR screens dissect IL17RC-mediated signaling events and immune outcomes.
Immunofluorescence, flow cytometry, and single-cell RNA sequencing determine IL17RC expression profiles in diverse cell populations.
Perturbation studies, siRNA knockdown, and gene editing differentiate IL17RC's roles in distinct IL17 cytokine pathways.
Customer Reviews (3)Write a review
High purity. -
Suitable for signaling studies. -
Effective in neutrophil activation. -
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