IL32
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Official Full Name
interleukin 32
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Background
This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. -
Synonyms
IL32; interleukin 32; NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd; IL-32beta; IL-32alpha; IL-32delta; IL-32gamma; interleukin-32; OTTHUMP00000236040; OTTHUMP00000236041; OTTHUMP00000236042; OTTHUMP00000236043; OTTHUMP00000236044; OTTHUMP00000236045; OTTHUMP00000236046; OTTHUMP00000236047; OTTHUMP00000236048; OTTHUMP00000236049; OTTHUMP00000236050; OTTHUMP00000236051; OTTHUMP00000236052; OTTHUMP00000236053; OTTHUMP00000236054; interleukin-32 theta; natural killer cells protein 4; natural killer cell transcript 4; tumor necrosis factor alpha-inducing factor;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL32 Related Research Area
IL32 involved in several pathways and played different roles in them. We selected most pathways IL32 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL32 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
IL32 has several biochemical functions, for example, cytokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL32 itself. We selected most functions IL32 had, and list some proteins which have the same functions with IL32. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | IFNA5;TNFRSF11B;CCL19A.1;IL21;Ifna15;IL33;IL28A;TNFSF15;CCL38A.4 |
| protein binding | CSNK2A2;FAM103A1;GNAI3;C6orf226;BCAP31;ZNF511;DNAIC2;ARPC2;PRSS21 |
IL32 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL32 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL32.
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- Q&As
- Reviews
Q&As (6)
Ask a questionAt present, research is ongoing, and IL32 is considered to have the potential to treat autoimmune diseases, but further clinical validation is required.
IL32, a protein of human origin, is an interferon-induced cytokine with a variety of biological functions.
IL32 is in clinical trials and will take time to evaluate its safety and efficacy.
IL32 induce and regulate inflammatory response and participate in immune and inflammatory processes.
Can enhance the activity and function of immune cells, thereby improving the body immunity.
So far, there have been no clear reports of side effects of IL32, but attention should be paid to reasonable dosage and method of use when using it.
Customer Reviews (3)
Write a reviewIL-32 has good structural stability under suitable storage conditions, which can maintain its structural integrity and functional activity, and the preservation and stability are very important in the process of production and use. -
Because the expression and function of IL-32 can vary across subtypes and shear variants, methods of producing IL-32 need to take into account the needs of specific subtypes to meet customized production needs. -
Through proper recombination technology and expression construction, the produced IL-32 can maintain good biological activity and function, and can play its immunomodulatory, anti-tumor, anti-inflammatory and antiviral effects. -
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