Recombinant Human IL-6 Protein

• Cat.No.: IL6R-1058H
• Product Overview: Recombinant Human interleukin-6 antigen is produced by E.coli expression system and the target gene encoding Pro29-Met212 is expressed. Predicted molecular weight: 21 kDa.

Specification

• Source: E.coli
• Species: Human
• Form: IL-6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is relevant to many disease processes such as diabetes, atherosclerosis, depression, Alzheimer's Disease, systemic lupus erythematosus, cancer, and rheumatoid arthritis. There is an interest in developing anti-IL-6 agents as therapy against many of these diseases. The first such is tocilizumab which has been approved for rheumatoid arthritis.
• Molecular Mass: 21 kDa
• Purity: > 90 % by SDS-PAGE
• Storage: -20 centigrade
• Concentration: 0.5 mg/ml when reconstituted with 100 µl of deionized water
• Storage Buffer: 20 mM Hac-NaAc, pH 5.0, 150 mM NaCl

Gene Information

• Gene Name: IL6R interleukin 6 receptor [ Homo sapiens ]
• Official Symbol: IL6R
• Synonyms: IL6R; interleukin 6 receptor; interleukin-6 receptor subunit alpha; CD126; IL-6R 1; CD126 antigen; membrane glycoprotein 80; IL-6 receptor subunit alpha; gp80; IL6RA; IL-6RA; IL-6R-1; MGC104991
• Gene ID: 3570
• mRNA Refseq: NM_000565
• Protein Refseq: NP_000556
• MIM: 147880
• UniProt ID: P08887