Active Recombinant Human IL6R Homodimer Protein, His tagged

• Cat.No.: IL6R-46H
• Product Overview: IL-6Rα protein dimer contains the IL-6Rα extracellular domain (UniProt# P08887) fused with a proprietary cis-dimer motif followed by a His tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293T
• Tag: His
• Protein Length: 20-365 aa
• Description: Human interleukin 6 receptor alpha (IL-6Rα) is a Type I transmembrane protein and Type I cytokine receptor and plays a crucial role in immune response, inflammation, and hematopoiesis. IL-6Rα is also known as Cluster of Differentiation 126 (CD126), IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, and gp80. IL-6Rα contains an extracellular domain with an Ig-like domain, cytokine binding module (CBM) domains, and a long flexible stalk region followed by a transmembrane domain and intracellular domains. IL-6Rα binding to its ligand interleukin 6 (IL-6) results in homodimerization and subsequent association with IL-6Rβ (gp130) dimer resulting in higher order complexes. IL-6Rα protein is involved in multiple disease processes due to its central role in IL-6 signaling. Dysregulation of IL-6Rα protein is implicated in many cancers and autoimmune diseases, therefore, a recombinant protein mimicking the IL-6Rα protein dimer conformation can be critical for basic research and therapeutic discovery.
• Molecular Mass: 93 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: SPR & ELISA for IL-6Rα and interleukin 6 (IL-6) ligand protein binding assays and ELISA for IL-6Rα-specific antibody binding assays. Suggested Applications: SPR & BLI for IL-6Rα-specific antibody and IL-6 protein binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: IL6R interleukin 6 receptor [ Homo sapiens (human) ]
• Official Symbol: IL6R
• Synonyms: IL6R; interleukin 6 receptor; interleukin-6 receptor subunit alpha; CD126; IL-6R 1; CD126 antigen; membrane glycoprotein 80; IL-6 receptor subunit alpha; gp80; IL6RA; IL-6RA; IL-6R-1; MGC104991
• Gene ID: 3570
• mRNA Refseq: NM_000565
• Protein Refseq: NP_000556
• MIM: 147880
• UniProt ID: P08887