Recombinant Human Interleukin 6 Receptor
Cat.No. : | IL6R-1242H |
Product Overview : | Recombinant humanIL6R is a single, non-glycosylated polypeptide chain containing 338 aminoacids (aa 20-357) corresponding to the mature IL6R protein with an aminoterminal hexahistidine tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL6R-1242H |
Description : | The IL6R complex is composed of two membrane glycoproteins: thelow affinity receptor and the signaltransducing component. The soluble formof IL6R is found in the urine of healthy adult humans and the serum of HIVpositive individuals, as well as in the cell culture supernatants ofstimulated PBMC's. This soluble form of IL6R results from either proteolyticcleavage from the membrane, or an isoform derived splice variant. |
Source : | E. coli |
Species : | Human |
Form : | Liquid in 20 mM TrisHCl pH 8 + 50% glycerol. |
MolecularWeight : | 42.25 kDa |
Purity : | > 95% by SDS-PAGEand HPLC analyses |
Endotoxin Level : | <0.1 ng/µg of IL6R |
Storage : | Store at 2-4°C ifentire vial will be used within 2-4 weeks. Store, frozen at -20°C for longerperiods of time. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | IL6R |
Gene Name : | IL6R interleukin 6 receptor [ Homosapiens ] |
Synonyms : | IL6R; interleukin 6receptor; CD126; IL-6R-1; IL6R-alpha; IL-6R-alpha;IL6RA; MGC104991; OTTHUMP00000034320; gp80; CD126 antigen; IL-6R 1;Interleukin-6 receptor alpha chain precursor; B cell stimulatory factor-2;Membrane glycoprotein 80; interleukin 6 receptor; interleukin 6 receptoralpha subunit. |
Gene ID : | 3570 |
mRNA Refseq : | NM_000565 |
Protein Refseq : | NP_000556 |
MIM : | 147880 |
UniProt ID : | P08887 |
Chromosome Location : | 1q21 |
Pathway : | Cytokine-cytokine receptorinteraction; Hematopoietic cell lineage; Jak-STAT signaling pathway |
Function : | ciliary neurotrophic factor binding;ciliary neurotrophic factor receptor activity;enzyme binding; interleukin-6receptor activity; protein homodimerization activity; receptor binding |
Products Types
◆ Recombinant Protein | ||
IL6R-213H | Recombinant Human IL6R Protein (ECD), His-tagged(C-ter) | +Inquiry |
IL6R-1054H | Recombinant Human IL6R Protein, His-tagged | +Inquiry |
IL6R-517H | Recombinant Human IL6R Protein, C13 and N15 Labeled | +Inquiry |
IL6R-235I | Active Recombinant Human IL6R Protein | +Inquiry |
IL6R-3154H | Recombinant Human IL6R Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IL6R-2903HCL | Recombinant Human IL6R cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe dose and route of administration need to be determined according to the specific treatment situation. Common routes of administration include subcutaneous injection and intravenous injection.
It can be used to treat certain autoimmune diseases, such as rheumatoid arthritis and psoriasis.
The IL6R is primarily used to treat inflammatory diseases that have already occurred, rather than prevent them.
IL6R reduces inflammation by binding to interleukin-6 (IL-6), blocking the IL-6 signaling pathway.
Although IL6R can regulate the immune system, it is not a direct anti-tumor drug.
The efficacy of IL6R is usually evaluated based on improvement of clinical symptoms, changes in disease activity, and changes in biochemical markers.
Customer Reviews (3)
Write a reviewGood compatibility and stability with the surfactant.
Expression level and stability of clones were good.
Remarkable antibacterial activity and bactericidal effect on bacteria.
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