Recombinant Human IL6R, Fc-tagged

• Cat.No.: IL6R-322H
• Product Overview: The extracellular domain of human IL-6R (aa 20-359) is fused to the N-terminus of the Fc region of human IgG1.

Specification

• Description: Interleukin-6 (IL-6) is a multifunctional factor, which exerts its activities through binding to a highaffinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6Ralpha;) and a signal transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for highaffinity binding of IL-6 by the complex. A soluble form of the IL-6Rα has been found in the urine of healthy adult humans.
• Source: CHO Cells
• Species: Human
• Tag: Fc
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Purity: ≥98% (SDS-PAGE)
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: IL6R interleukin 6 receptor [ Homo sapiens ]
• Official Symbol: IL6R
• Synonyms: IL6R; interleukin 6 receptor; interleukin-6 receptor subunit alpha; CD126; IL-6R 1; CD126 antigen; membrane glycoprotein 80; IL-6 receptor subunit alpha; gp80; IL6RA; IL-6RA; IL-6R-1; MGC104991
• Gene ID: 3570
• mRNA Refseq: NM_000565
• Protein Refseq: NP_000556
• MIM: 147880
• UniProt ID: P08887
• Chromosome Location: 1q21
• Pathway: Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; IL-6 Signaling Pathway, organism-specific biosystem; IL6-mediated signaling events, organism-specific biosystem
• Function: ciliary neurotrophic factor binding; contributes_to ciliary neurotrophic factor receptor activity; enzyme binding; interleukin-6 binding; contributes_to interleukin-6 receptor activity; contributes_to interleukin-6 receptor binding; protein binding; protein homodimerization activity; receptor activity

Reviews

02/23/2022

Good compatibility and stability with the surfactant.

11/23/2020

Expression level and stability of clones were good.

02/01/2019

Remarkable antibacterial activity and bactericidal effect on bacteria.

Q&As

What is the dose and route of administration of IL6R?

The dose and route of administration need to be determined according to the specific treatment situation. Common routes of administration include subcutaneous injection and intravenous injection.

Can recombinant IL6R be used in autoimmune diseases?

It can be used to treat certain autoimmune diseases, such as rheumatoid arthritis and psoriasis.

Can recombinant IL6R be used to prevent disease?

The IL6R is primarily used to treat inflammatory diseases that have already occurred, rather than prevent them.

How the action mechanism of IL6R?

IL6R reduces inflammation by binding to interleukin-6 (IL-6), blocking the IL-6 signaling pathway.

Does IL6R have anti-tumor effects?

Although IL6R can regulate the immune system, it is not a direct anti-tumor drug.

How to evaluate the efficacy of IL6R?

The efficacy of IL6R is usually evaluated based on improvement of clinical symptoms, changes in disease activity, and changes in biochemical markers.