Recombinant Human Interleukin 6 Receptor

• Cat.No.: IL6R-545H
• Product Overview: Recombinant human IL6Rwas expressed in HEK 293 cells and purified recombinant Human IL6R alphaprotein.

Specification

• Cat. No.: IL6R-545H
• Description: IL6 mediates itsbiological effects through the type I IL6 receptor system that consists oftwo chains, IL6R and gp130. The IL6R chain is the binding component specificto IL6; while the gp130 only transmits signals of IL6 when bound to IL6R. Thegp130 also can transmit signals from LIF, OSM, CNTF, IL11 and CT-1 inconjunction with other receptor subunits. The low-affinity binding site forIL6 is composed of IL6R alone. IL6R is expressed in a wide range of cellsincluding T cells, fibroblasts and macrophages. Soluble IL6R which consistsof only the extracellular domain of the IL6R chain, acts as an agonist of IL6activity at low concentrations.
• Source: Human
• Host: HEK 293 cells
• Form: Lyophilized from1xPBS. Reconstitute in 1XPBS to a concentration of 0.1-1.0 mg/ml. Whendissolved, dilute further into aqueous buffered solutions.
• Purity: > 98% pure by SDSPAGE and HPLC
• Sequence: Region of IL6Rprotein corresponding to amino acids LAPRRCPAQE VARGVLTSLP GDSVTLTCPGVEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQLSCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYIVSMCVASSVG SKFSK
• Molecular Mass: 37.6 kDa
• Applications: Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
• Storage: Store at 4 deg Cuntil reconstitution. Following reconstitution aliquot and freeze at -20 degC for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: IL6R

Gene Information

• Gene Name: IL6Rinterleukin 6 receptor [ Homo sapiens ]
• Synonyms: IL6R; interleukin 6 receptor;Interleukin-6 receptor subunit alpha; IL-6R-alpha; IL-6R 1; Membraneglycoprotein 80; gp80; CD126; IL-6R-1; MGC104991; OTTHUMP00000034320; CD126antigen
• Gene ID: 3570
• mRNA Refseq: NM_000565
• Protein Refseq: NP_000556
• MIM: 147880
• UniProt ID: P08887
• Chromosome Location: 1q21
• Pathway: Cytokine Signalingin Immune system; Cytokine-cytokine receptor interaction; Hematopoietic celllineage; IL-6 Signaling Pathway; IL6-mediated signaling events; Immune System;Interleukin-6 signaling; Jak-STAT signaling pathway; SIDS SusceptibilityPathways; Senescence and Autophagy; Signaling by Interleukins
• Function: ciliary neurotrophic factorbinding; ciliary neurotrophic factor receptor activity; enzyme binding;interleukin-6 receptor activity; interleukin-6 receptor binding; proteinhomodimerization activity; receptor activity; contributes_tointerleukin-6 receptor binding; protein binding