JUN

  • Official Full Name

    jun proto-oncogene

  • Overview

    Transcription factor AP-1; JUN; AP-1; AP1; c-Jun; jun proto-oncogene; p39; jun oncogene; activator protein 1; proto-oncogene c-Jun; enhancer-binding protein AP1; Jun activation domain binding protein; v-jun sarcoma virus 17 oncogene homolog; v-jun avian sarcoma virus 17 oncogene homolog
  • Synonyms

    JUN; jun proto-oncogene; jun oncogene ,v jun avian sarcoma virus 17 oncogene homolog ,v jun sarcoma virus 17 oncogene homolog (avian); transcription factor AP-1; AP 1; c Jun; Activator Protein 1; AP 1; AP1; cJun; Enhancer Binding Protein AP1; Jun Activation Domain Binding Protein; JUN; Jun oncogene; JUN protein; Jun proto oncogene; JUN_HUMAN; JUNC; Oncogene JUN; p39; Proto oncogene c jun; Proto oncogene cJun; Proto-oncogene c-jun; Transcription Factor AP 1; Transcription factor AP-1; Transcription Factor AP1; V jun avian sarcoma virus 17 oncogene homolog; V jun sarcoma virus 17 oncogene homolog (avian); V-jun avian sarcoma virus 17 oncogene homolog; vJun Avian Sarcoma Virus 17 Oncogene Homolog; p39; jun oncogene; OTTHUMP00000010036; activator protein 1; proto-oncogene c-Jun; enhancer-binding protein AP1; Jun activation domain binding protein; v-jun sarcoma virus 17 oncogene homolog; v-jun avian sarcoma virus 17 oncogene homolog; AP1; AP-1; c-Jun;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human JUN-105H Active Recombinant Human JUN, His-tagged Insect Cell His
Human JUN-1027H Active Recombinant Human Jun Oncogene Insect Cell N/A
Human JUN-646H Recombinant Human Jun Oncogene, GST-tagged E.coli GST
Human JUN-27752TH Recombinant Human JUN E.coli N/A
Human JUN-20H Recombinant Human jun oncogene, His-tagged E.coli His
Human JUN-792H Recombinant Human Jun, His-tagged, 27.3 kDa (261 aa) E.coli His
Human JUN-8483H Recombinant Human JUN, His-tagged E.coli His
Human JUN-4856H Recombinant Human Jun Proto-Oncogene, GST-tagged E.coli GST
Human JUN-18H Recombinant Human JUN protein, GST-tagged Wheat Germ GST
Human JUN-291H Recombinant Human JUN protein, His/MBP-tagged E.coli His/MBP
Human JUN-292H Recombinant Human JUN protein, His/MBP-tagged E.coli His/MBP
Human JUN-5095HCL Recombinant Human JUN 293 Cell Lysate HEK293 N/A
Human JUN-715HF Recombinant Full Length Human JUN Protein, GST-tagged In Vitro Cell Free System GST
Human JUN-3132H Recombinant Human JUN Protein (Met1-Phe331), N-His tagged E.coli N-His
Human JUN-3133H Recombinant Human JUN Protein (Asp11-Asn262), N-His tagged E.coli N-His
Mouse JUN-8438M Recombinant Mouse JUN Protein Mammalian Cell His
Mouse JUN-4693M Recombinant Mouse JUN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse JUN-4693M-B Recombinant Mouse JUN Protein Pre-coupled Magnetic Beads HEK293
Rat JUN-3146R Recombinant Rat JUN Protein Mammalian Cell His
Rat JUN-2802R Recombinant Rat JUN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat JUN-2802R-B Recombinant Rat JUN Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque JUN-2335R Recombinant Rhesus monkey JUN Protein, His-tagged Mammalian Cell His
Rhesus Macaque JUN-2156R Recombinant Rhesus Macaque JUN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque JUN-2156R-B Recombinant Rhesus Macaque JUN Protein Pre-coupled Magnetic Beads HEK293
Zebrafish JUN-10349Z Recombinant Zebrafish JUN Mammalian Cell His
Chicken JUN-2945C Recombinant Chicken JUN Mammalian Cell His
Chicken JUN-1498G Recombinant Gallus gallus JUN Protein (Full Length), N-His tagged E.coli N-His
Chicken JUN-1499G Recombinant Gallus gallus JUN Protein (Ser228-Gly298), N-His tagged E.coli N-His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • JUN Related Articles
  • JUN Related Research Area
  • JUN Related Signal Pathway

JUN involved in several pathways and played different roles in them. We selected most pathways JUN participated on our site, such as AGE/RAGE pathway, ATF-2 transcription factor network, Activated TLR4 signalling, which may be useful for your reference. Also, other proteins which involved in the same pathway with JUN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AGE/RAGE pathwayDIAPH1;CHUK;MAPK14;LGALS3;EGFR;MMP13;DDOST;JUN;ATF2
ATF-2 transcription factor networkRUVBL2;MAPK14;CBFB;CSRP2;DUSP10;DUSP5;JDP2;CREB1;CDK4
Activated TLR4 signallingPELI3;DHX9;AGER;DUSP3;SIGIRR;DUSP3B;NOD1;UBE2V1;S100B
Activation of the AP-1 family of transcription factorsMAPK14;JUN;ATF2
AhR pathwayJUND;NQO1;CDC37;FLG;AHR;PTGES3;EGFR;CYP1B1;CYP1A2
Androgen receptor signaling pathwayDAXX;JUN;RUNX2A;CARM1;SMAD3B;CDKN1A;CCDC102A;RHOB;GNB2L1
ApoptosisDSG1;FASLG;IRAK2;MAP3K14;DNM1L;PRKACAB;PKP1;PIK3R5;Casp3

JUN has several biochemical functions, for example, DNA binding, GTPase activator activity, HMG box domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JUN itself. We selected most functions JUN had, and list some proteins which have the same functions with JUN. You can find most of the proteins on our site.

Function Related Protein
DNA bindingOTPB;SMAD6A;EEPD1;CDAN1;HER4.2;ZNF2;RORAB;DRL;HIST1H2AA
GTPase activator activityAXIN1;GDI1;RALBP1;TBC1D4;ARHGDIA;ASAP3;ALS2CL;TBC1D3C;TBC1D15
HMG box domain bindingGATA3;HHEX;PRRX1;HOXA3;CEBPA;MEOX1;OLIG2;DLX5;SP1
R-SMAD bindingZEB2;ZC3H3;SMAD6;FOS;JUN;ANKRD1;RANBP3;C18orf1;FOXH1
RNA polymerase II activating transcription factor bindingRB1;HIPK2;POU1F1;TBX3;EP300;HNF4A;ZFPM1;JUN;SMAD3
RNA polymerase II core promoter proximal region sequence-specific DNA bindingZNF486;GZF1;ZNF562;NFKB2;NR4A3;ZNF460;PAX5;PDX1;PHOX2B
RNA polymerase II distal enhancer sequence-specific DNA bindingCDX1;GATA2;NFE2L1;SPI1;HNRNPC;GZF1;ARX;RELA;FLI1
RNA polymerase II transcription factor activity, sequence-specific DNA bindingBMPR1A;TP73;ATF4B2;FOXJ3;RELB;ZNF18;HIF1AL;KLF11;SOX9B
cAMP response element bindingCREB3L2;CREB1;ATF2;HMGA2;ATF6;CREB3L4;ATF6B;JUN;CREB3L1
chromatin bindingARID5A;UBTFL;CRTC2;BAHCC1;AIRE;NFKB1;SMARCD3;MLL1;HMGXB4
enzyme bindingLUC7L2;C6orf211;MLL5;SRC;SNX12;PPP1R3B;DAOA;HDAC6;POR
poly(A) RNA bindingDKC1;EIF3A;RPS27A;RBM4;EIF3E;POLRMT;TES;PAN3;MRPL32
protein bindingAMIGO2;TP73;WDFY3;ISYNA1;UBE2W;NKX2-1;CCDC28A;ORM1;THRAP3
transcription coactivator activityTAF7L;CTBP2;NR2F1;APEX1;CALCOCO1;SUPT3H;HIF3A;CDK7;CD3D
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingNKX2;MEF2C;SNAI2;PAX3;NFIX;MYF6;FOXF1;MYF5;BHLHE40
transcription factor activity, sequence-specific DNA bindingFOXA3;HOXD3A;SCAND1;RFX3;MTA3;FOXN2;GTF2IRD1;RFXANK;PURBB
transcription factor bindingTAF7;ARNT;NFYC;PER1;RNF4;HIF1A;DACT2;MECP2;PPID
transcription regulatory region DNA bindingBCL11AA;ZNF174;GRHL2B;ZFP382;TFAP2A;SOX2;POU5F1;TBL1XR1;TAF2
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingMEF2B;MEF2A;ELF1;EGR1;ZFAT;FLI1;EGR2;CREB3L1;HLTF
transcriptional activator activity, RNA polymerase II transcription factor bindingCREB1;MED12;KLF4;PPARA;NR1H4;PITX1;KLF14;GBX2;NKX2

JUN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JUN here. Most of them are supplied by our site. Hope this information will be useful for your research of JUN.

FOS

Toyota, H; Sudo, K; et al. Thy28 protects against anti-CD3-mediated thymic cell death in vivo. APOPTOSIS 20:444-454(2015).
Rodriguez, AM; Davila, MP; et al. Tumor Necrosis Factor alpha Phosphorylates c-Jun N-Terminal Kinase in Stallion Spermatozoa: Effect of Cryopreservation. JOURNAL OF EQUINE VETERINARY SCIENCE 35:206-212(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How can diseases be treated by regulating the expression level of JUN? 12/03/2022

There are currently no drugs that directly regulate the expression level of JUN, but some JUN-related diseases can be treated by inhibiting its activity or regulating its expression.

What is the relationship of JUN to other genes or proteins? 09/06/2022

JUN has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

How are mutations in JUN detected and analyzed? 09/02/2022

Mutations in JUN can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

What are the mutation types of JUN? 12/06/2021

The types of mutations in JUN include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

How to study the regulatory mechanism of JUN? 11/02/2020

Studying the regulatory mechanism of JUN requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

What is the specific role of JUN in the cell cycle? 03/23/2020

JUN plays an important role in the cell cycle, which can promote the transition of cells from G1 phase to S phase and promote cell proliferation and differentiation.

Customer Reviews (3)

Write a review
Reviews
04/18/2022

    The stability of the protein indicates ease of storage.

    11/21/2021

      High biological activity.

      07/15/2021

        Highly expressed in the expression system.

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