Recombinant Human JUN, His-tagged

• Cat.No.: JUN-8483H
• Product Overview: Recombinant Human JUN was expressed as 6*his-tagged fusion protein by E.Coli and puri?ed by Ni-sepharose.

Specification

• Description: This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-331
• AA Sequence: 1-331aa
• Storage: The protein is stored in PBS bu?er at -20 oC. Repeated freeze-thaw cycles should be avoided.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: JUN jun proto-oncogene [ Homo sapiens (human) ]
• Official Symbol: JUN
• Synonyms: JUN; AP1; AP-1; c-Jun; jun proto-oncogene; transcription factor AP-1; p39; jun oncogene; activator protein 1; proto-oncogene c-Jun; enhancer-binding protein AP1; Jun activation domain binding protein; v-jun sarcoma virus 17 oncogene homolog; v-jun avian sarcoma virus 17 oncogene homolog
• Gene ID: 3725
• mRNA Refseq: NM_002228
• Protein Refseq: NP_002219
• MIM: 165160
• UniProt ID: P05412
• Chromosome Location: 1p32-p31
• Pathway: AGE/RAGE pathway; Activated TLR4 signalling; B Cell Receptor Signaling Pathway
• Function: DNA binding; HMG box domain binding; RNA polymerase II activating transcription factor binding

Reviews

04/18/2022

The stability of the protein indicates ease of storage.

11/21/2021

High biological activity.

07/15/2021

Highly expressed in the expression system.

Q&As

How can diseases be treated by regulating the expression level of JUN?

There are currently no drugs that directly regulate the expression level of JUN, but some JUN-related diseases can be treated by inhibiting its activity or regulating its expression.

What is the relationship of JUN to other genes or proteins?

JUN has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.

How are mutations in JUN detected and analyzed?

Mutations in JUN can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

What are the mutation types of JUN?

The types of mutations in JUN include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

How to study the regulatory mechanism of JUN?

Studying the regulatory mechanism of JUN requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

What is the specific role of JUN in the cell cycle?

JUN plays an important role in the cell cycle, which can promote the transition of cells from G1 phase to S phase and promote cell proliferation and differentiation.