Recombinant Human Jun Oncogene, GST-tagged
Cat.No. : | JUN-646H |
Product Overview : | Recombinant Human Jun Oncogene was expressed in E. coli. It was fused at the N-terminus to a GST tag. MW=68 KDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | JUN-646H |
Description : | c-Jun is an important proto-oncogene and transactivating factor that is a component of the AP-1 and ATF-2 transcription factors. c-Jun is acutely regulated by a wide variety of cellular signals via modulation of its phosphorylation state, which can both inhibit and activate the proto-oncogene. Phosphorylation by GSK-3 at a region proxim al to the highly basic DNA binding domain (Thr239/Ser243/Ser249) prevents DNA association with c-Jun homodimers, but not with c-Jun-c-Fos heterodimers. Phosphorylation catalyzed by JNK/SAPK at Ser63 and Ser73, in a region proximal to the transactivation domain, activates the c-Jun/AP-1 and c-Jun/ATF2 transcriptional activator complexes to induce a number of genes. The MAP kinases ERK1 and ERK2 also phosphorylate c-Jun at Thr91/Thr93/Thr95. The preparations are suitable for studies on the kinetics, enzymology and regulation of the phosphorylation of the important proto-oncogene. The purified preparations are effective as substrate for JNK/SAPK, MAPK, GSK-3 and CK-2 among other protein kinases. |
Source : | E. coli. |
Purity : | > 90% by SDS-PAGE. |
Supplied : | Supplied 5 mg in 50 ml of 50 mM Tris-HCl pH 7.0 buffer containing 14 mM b-mercaptoethanol. |
Disclaimer : | GloboZymes products are for basic science research purposes only. They are not intended for human drug. |
Storage : | Maintain preparations in aliquots at -70oC. Avoid repeated thawing. |
Gene Name : | JUN jun oncogene [ Homo sapiens ] |
Synonyms : | JUN; jun oncogene; AP1; AP-1; c-Jun; activator protein 1; enhancer-binding protein AP1; Jun activation domain binding protein; v-jun sarcoma virus 17 oncogene homolog; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian) |
Gene ID : | 3725 |
mRNA Refseq : | NM_002228 |
Protein Refseq : | NP_002219 |
MIM : | 165160 |
UniProt ID : | P05412 |
Chromosome Location : | 1p32-p31 |
Pathway : | B cell receptor signaling pathway; Colorectal cancer; Epithelial cell signaling in Helicobacter pylori infection; ErbB signaling pathway; Focal adhesion; GnRH signaling pathway; MAPK signaling pathway; Neurotrophin signaling pathway; Pathways in cancer; Renal cell carcinoma; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Wnt signaling pathway |
Function : | R-SMAD binding; RNA polymerase II transcription factor activity; Rho GTPase activator activity; double-stranded DNA binding; promoter binding; protein dimerization activity; transcription factor activity; transcription factor binding |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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