Lcn2
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Official Full Name
lipocalin 2
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Synonyms
LCN2; lipocalin 2; 24p3; MSFI; NGAL; neutrophil gelatinase-associated lipocalin; p25; lipocalin-2; oncogene 24p3; siderocalin LCN2; migration-stimulating factor inhibitor; 25 kDa alpha-2-microglobulin-related subunit of MMP-9;
- Recombinant Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Dog
- Gln21-Gly198
- Human
- Mouse
- Pig
- Rat
- Baculovirus-Infected Sf9 Cells
- C-His
- E.coli
- HEK293
- HEK293 cells
- HEK293F
- HEK293T
- Human Cell
- Human Neutrophil
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- P.pastoris
- Fc
- Flag
- GFP
- GST
- His
- Avi
- T7
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
Lcn2 involved in several pathways and played different roles in them. We selected most pathways Lcn2 participated on our site, such as Iron uptake and transport, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with Lcn2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Iron uptake and transport | CP;FLVCR1;TFA;FTH1B;SLC22A17;FTH1A;TCIRG1;LCN2;SLC46A1 |
| Transmembrane transport of small molecules | SLC6A6A;SLC9A8;PIP;SLC4A4A;SLC26A7;SLC4A1A;ATP13A1;SLC36A2;TSC22D3 |
Lcn2 has several biochemical functions, for example, iron ion binding, protease binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Lcn2 itself. We selected most functions Lcn2 had, and list some proteins which have the same functions with Lcn2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | CYP46A1.4;CYP2X7;CYP1B1;SC5DL;CYP2K22;CYP2B6;HBAA1;TMEM195;MFI2 |
| protease binding | ITGA3;SRI;LRP1;CFLAR;SERPINA1E;Cstb;BRCA2;CST3;CAST |
| protein homodimerization activity | XCL1;XDH;PEX7;TFAP2A;VEGFB;PSPH;NR6A1B;TREX1;NOS1 |
| small molecule binding | PAEP;MUP3;PTGDSB;LCN2;RBP4L;LCN15;MUP17;AMBP;MUP20 |
| transporter activity | MIPA;PMP2;SYPL2A;SLC5A11;NUP88;SLC37A4A;ABCA13;SLC22A13;SLC2A8 |
Lcn2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Lcn2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Lcn2.
Research Area
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Customer Reviews (3)
Write a reviewThey have a wide range of products and can always find LCN2 we need.
The reproducibility of LCN2 is almost 100 percent, and the results are very consistent in every experiment or application, which is an important reflection of its excellent quality.
Catalytic activity of LCN2 is really amazing, and every time it is used, it gives an unexpected catalytic effect and its performance is impressive.
Q&As (6)
Ask a questionMutations or abnormal expression of the LCN2 protein may be associated with a variety of diseases. For example, in hereditary kidney disease, mutations in the uNGAL gene can lead to kidney damage. In addition, in inflammatory diseases, tumors, and other diseases, the expression level of LCN2 protein may also change.
Studies have shown that the expression level of LCN2 protein is associated with a variety of diseases. For example, in kidney disease, expression levels of the LCN2 protein can be elevated and can be used as one of the biomarkers to assess the extent of kidney damage. In addition, in inflammatory diseases, tumors, and other diseases, the expression level of LCN2 protein can also change.
The interaction between the LCN2 protein and other proteins or molecules is complex. For example, it can participate in lipid metabolism processes by interacting with lipid molecules. In addition, it can interact with other signal transduction molecules to participate in the signal transduction process.
Kidney function can be assessed by measuring the level of uNGAL in urine, and to help diagnose kidney disease, etc. In addition, abnormal levels of LCN2 protein expression can also be used as an indicator to assess the risk and prognosis of other diseases.
The activity of the LCN2 protein is regulated by a variety of factors. First, its expression level is regulated by gene expression. Secondly, its activity is also regulated by a variety of small molecule compounds, hormones and other substances. In addition, the LCN2 protein can also regulate its activity by interacting with other proteins.
LCN2 protein has some association with other biomarkers. For example, in kidney disease, expression levels of uNGAL can be used alongside traditional biomarkers such as creatinine to assess kidney function and degree of impairment. In addition, in diseases such as tumors, expression levels of the LCN2 protein may also change and be associated with other biomarkers.
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