Recombinant Mouse/Rat Nog Protein

• Cat.No.: Nog-28M
• Product Overview: Recombinant mouse/rat noggin protein without tag was expressed in E. coli.
  Animal-free (AOF) and carrier protein-free.
  Mass spectrometry: single species with expected mass.
  Analytical reversed-phase: single sharp peak.
  Recovery from stock vial: >95%

Specification

• Description: Predicted to enable cytokine binding activity and protein homodimerization activity. Involved in several processes, including circulatory system development; negative regulation of cell differentiation; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including branchial arch; embryo ectoderm; heart; limb; and sensory organ. Used to study esophageal atresia/tracheoesophageal fistula. Human ortholog(s) of this gene implicated in Huntington's disease; cleft lip; dysostosis (multiple); hyperopia; and proximal symphalangism (multiple). Orthologous to human NOG (noggin).
• Source: E. coli
• Species: Mouse/Rat
• Molecular Mass: 46 kDa (dimer)
• Endotoxin: <0.005 EU/μg protein (below level of detection)
• Applications: Stem cell Expansion and maintenance; primary cell culture
• Storage: Resuspend in 10mM HCl at >100 μg/mL, prepare single use aliquots, add carrier protein if desired and store frozen at -20 or -80 centigrade
• Storage Buffer: Lyophilized from acetonitrile, TFA

Gene Information

• Gene Name: Nog noggin [ Mus musculus (house mouse) ]
• Official Symbol: Nog
• Synonyms: NOG; noggin; SYM1; SYNS1; SYNS1A; noggin; symphalangism 1 (proximal)
• Gene ID: 18121
• mRNA Refseq: NM_008711
• Protein Refseq: NP_032737
• UniProt ID: P97466