P4HB

  • Official Full Name

    prolyl 4-hydroxylase, beta polypeptide

  • Overview

    This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to;the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this;enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase;containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other;known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a;concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of;S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein;complex.
  • Synonyms

    P4HB; prolyl 4-hydroxylase, beta polypeptide; ERBA2L, PO4DB, procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide , procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide (prote;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Chinese hamster
  • Cricetulus Griseus
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human P4HB-19H Active Recombinant Human P4HB protein, His-tagged E.coli His
Human P4HB-2760H Recombinant Human P4HB, His-tagged E.coli His
Human P4HB-310H Active Recombinant Human P4HB protein, His-tagged HEK293 His Met1-Lys505
Human P4HB-27008TH Recombinant Human P4HB, His-tagged E.coli His
Human P4HB-30545TH Recombinant Human P4HB, His-tagged E.coli His
Human P4HB-116H Recombinant Human P4HB, MYC/DDK-tagged HEK293 Myc/DDK
Human P4HB-2764HCL Recombinant Human P4HB cell lysate Human Cell N/A
Human P4HB-1478H Recombinant Human P4HB Protein (18-508 aa), His-tagged Yeast His 18-508 aa
Human P4HB-5138H Recombinant Human P4HB protein, GST-tagged E.coli GST 29-313aa
Human P4HB-5720HFL Recombinant Full Length Human P4HB, Flag-tagged Mamanlian cells Flag
Human P4HB-4780H Recombinant Human P4HB Protein (Asp18-Lys505), C-His tagged E.coli C-His Asp18-Lys505
Human P4HB-6656H Recombinant Human P4HB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human P4HB-4782H Recombinant Human P4HB Protein (Phe216-Gly465), N-GST tagged E.coli N-GST Phe216-Gly465
Mouse P4hb-1450M Recombinant Mouse P4hb protein, His & GST-tagged E.coli His/GST Asp212~Arg463 (Accession # P09103)
Mouse P4hb-1130M Active Recombinant Mouse P4hb protein, His-tagged HEK293 His Met1-Lys506
Mouse P4HB-33M Recombinant Mouse P4HB Protein, His-tagged Insect Cell His
Mouse P4HB-2121MCL Recombinant Mouse P4HB cell lysate Human Cell N/A
Mouse P4hb-7294M Recombinant Mouse P4hb Protein, His-tagged Insect Cell His 20-509
Mouse P4hb-4642M Recombinant Mouse P4hb Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat P4hb-1451R Recombinant Rat P4hb protein, His & GST-tagged E.coli His/GST Asp269~Asp507 (Accession # P04785)
Rat P4HB-4242R Recombinant Rat P4HB Protein Mammalian Cell His
Rat P4HB-3904R Recombinant Rat P4HB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat P4HB-3904R-B Recombinant Rat P4HB Protein Pre-coupled Magnetic Beads HEK293
Chinese hamster P4HB-5800C Recombinant Chinese hamster P4HB protein, His-tagged Yeast His 20-509aa
Cricetulus Griseus P4HB-2042C Recombinant Cricetulus Griseus P4HB Protein (20-509 aa), His-tagged E.coli His 20-509 aa
Zebrafish P4HB-12543Z Recombinant Zebrafish P4HB Mammalian Cell His
Chicken P4HB-4209C Recombinant Chicken P4HB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

P4HB involved in several pathways and played different roles in them. We selected most pathways P4HB participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulumMAN1A1;UBE2E1;ATF4B1;WFS1;TXNDC5;SEC13;HSP70;MAPK8A;PDIA6

P4HB has several biochemical functions, for example, endopeptidase activity, enzyme binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HB itself. We selected most functions P4HB had, and list some proteins which have the same functions with P4HB. You can find most of the proteins on our site.

Function Related Protein
endopeptidase activityMMP9;PSMB5;P4HB;KLK1B16;ELANE;PSMB10;KLK1B24;MMP1;KLK1B1
enzyme bindingKDM4C;TARBP2;BLZF1;USP22;RCOR2;PRKCE;HDAC2;TTN;PCCA
integrin bindingTSPAN8;ACTN3;FCER2;ICAM5;TGFBI;SYK;L1CAM;ADAM10;NF2
poly(A) RNA bindingZFP106;GRWD1;PSIP1;MPHOSPH10;FAM50A;ATP5A1;SAMD4B;RPL10;MTO1
contributes_to procollagen-proline 4-dioxygenase activity
protein bindingPAK2;RNF220;NAV1;HACE1;ZNF124;UBE2L3;PRLR;NKD1;SUMO3
protein disulfide isomerase activityTXNDC11;ERO1LB;ERP44;PDIA2;ERO1L;PDIA4;ZNF169;PDIA5;TXNDC5
protein heterodimerization activityTENM3;TCF4;HEYL;OSTB;ADRA1B;SDCBP2;EGFR;HIST1H4A;ADRB1

P4HB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HB here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HB.

ERO1L; heparin; GABARAPL2; TAP1; env; MAPT; MAPT; PRDX4; PDIA3

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