P4HB
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Official Full Name
prolyl 4-hydroxylase, beta polypeptide
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Overview
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to;the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this;enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase;containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other;known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a;concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of;S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein;complex. -
Synonyms
P4HB; prolyl 4-hydroxylase, beta polypeptide; ERBA2L, PO4DB, procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide , procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide (prote;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Chinese hamster
- Cricetulus Griseus
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human Cell
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Yeast
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
P4HB involved in several pathways and played different roles in them. We selected most pathways P4HB participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | DNAJC5G;DNAJC5GB;SAR1B;TUSC3;UBE2G1A;SAR1A;SEL1L2;MAN1A2;HSP90AA1 |
P4HB has several biochemical functions, for example, endopeptidase activity, enzyme binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HB itself. We selected most functions P4HB had, and list some proteins which have the same functions with P4HB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activity | NAPSA;KLK1B1;HTRA4;PSMB9A;CTSH;PSMA7;ACE2;TRAPPC12;KLK1B3 |
| enzyme binding | H2AFX;TRIO;NPM2;PARP4;YWHAE;DYM;RPS19BP1;TBP;CASC3 |
| integrin binding | ECM2;ACTN3;PTPN2;ADAM22;ITGB1;PPAP2B;Npnt;COL4A3;PXN |
| poly(A) RNA binding | RIMS1;THOC4;SRP68;BICC1;EIF4G1;APEX1;RBM15B;ISG20L2;LRRC59 |
| contributes_to procollagen-proline 4-dioxygenase activity | |
| protein binding | HHIPL2;CYLD;UBOX5;UCP3;TRAPPC2L;MLC1;EPB42;JMJD6;COLQ |
| protein disulfide isomerase activity | QSOX1;TXNDC5;PDIA4;TMX1;TXNDC11;PDIA6;PIGK;ITGB3;PDIA5 |
| protein heterodimerization activity | GCA;ADORA1;MAFA;BCL2L1;HIST1H4C;CEBPA;HIST1H4E;HIF1A;CHUK |
P4HB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HB here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HB.
ERO1L; heparin; GABARAPL2; TAP1; env; MAPT; MAPT; PRDX4; PDIA3
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