Recombinant Human P4HB Protein (18-508 aa), His-tagged

Cat.No. : P4HB-1478H
Product Overview : Recombinant Human P4HB Protein (18-508 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Cancer. Protein Description: Full Length of Mature Protein.
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Description : This multifunctional protein catalyzes the formation, breakage and rearrangent of disulfide bonds. At the cell surface, ses to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, ses to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.
Source : Yeast
Species : Human
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 57.3 kDa
Protein length : 18-508 aa
AA Sequence : DAPEEEDHVLVLRKSNFAEALAAHK YLLVEFYAPWCGHCKALAPEYAKAA GKLKAEGSEIRLAKVDATEESDLAQ QYGVRGYPTIKFFRNGDTASPKEYT AGREADDIVNWLKKRTGPAATTLPD GAAAESLVESSEVAVIGFFKDVESD SAKQFLQAAEAIDDIPFGITSNSDV FSKYQLDKDGVVLFKKFDEGRNNFE GEVTKENLLDFIKHNQLPLVIEFTE QTAPKIFGGEIKTHILLFLPKSVSD YDGKLSNFKTAAESFKGKILFIFID SDHTDNQRILEFFGLKKEECPAVRL ITLEEEMTKYKPESEELTAERITEF CHRFLEGKIKPHLMSQELPEDWDKQ PVKVLVGKNFEDVAFDEKKNVFVEF YAPWCGHCKQLAPIWDKLGETYKDH ENIVIAKMDSTANEVEAVKVHSFPT LKFFPASADRTVIDYNGERTLDGFK KFLESGGQDGAGDDDDLEDLEEAEE PDMEEDDDQKAVKDEL
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
SDS-PAGE: (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Gene Name : P4HB prolyl 4-hydroxylase, beta polypeptide [ Homo sapiens ]
Official Symbol : P4HB
Synonyms : P4HB; DSI; GIT; P4Hbeta; PDI; PDIA1; PO4HB; PROHB; p55; PHDB; PO4DB; ERBA2L;
Gene ID : 5034
mRNA Refseq : NM_000918
Protein Refseq : NP_000909
MIM : 176790
UniProt ID : P07237

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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