Recombinant Human P4HB, His-tagged

Cat.No. : P4HB-30545TH
Product Overview : Recombinant Human P4HB fused at the N terminal to a His-tag, predicted Mwt: 58 kDa.
  • Specification
  • Gene Information
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Description : This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.
Conjugation : HIS
Molecular Weight : 58.000kDa
Source : E. coli
Biological activity : >200U/mg
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : pH: 7.50Constituents:0.61% Tris, 0.88% Sodium chloride, 5% Glycerol, 0.02% DTT, 0.03% EDTA
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein disulfide isomerase family.Contains 2 thioredoxin domains.
Gene Name : P4HB prolyl 4-hydroxylase, beta polypeptide [ Homo sapiens ]
Official Symbol : P4HB
Synonyms : P4HB; prolyl 4-hydroxylase, beta polypeptide; ERBA2L, PO4DB, procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide , procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide (prote
Gene ID : 5034
mRNA Refseq : NM_000918
Protein Refseq : NP_000909
MIM : 176790
Uniprot ID : P07237
Chromosome Location : 17q25
Pathway : Chylomicron-mediated lipid transport, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Lipoprotein metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem;
Function : electron carrier activity; isomerase activity; procollagen-proline 4-dioxygenase activity; protein binding; protein disulfide isomerase activity;

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