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Recombinant Human P4HB, His-tagged

Cat.No. : P4HB-27008TH
Product Overview : Recombinant Full-length Human P4HB with an N-terminal 6xHis-tag is a single, non-glycosylated, polypeptide chain containing 508 amino acids and having a molecular mass of 57 kDa.
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Description : This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.
Conjugation : HIS
Source : E. coli
Biological activity : Reductase Activity:1.0 x 10-3 OD650nm/ min-2. By measuring the turbidity increase at 650 nm due to insulin reduction (Holmgren, A. (1979) J. Biol. Chem. 254, 9627–9632). The activity is expressed as the ratio of the slope of a linear part of the turbidity
Form : Lyophilised:Reconstitutein sterile 18Mohm/cmwater at not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50mM Potassium phosphate, pH 7.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Arg-Arg-Ala.
Sequence Similarities : Belongs to the protein disulfide isomerase family.Contains 2 thioredoxin domains.
Gene Name : P4HB prolyl 4-hydroxylase, beta polypeptide [ Homo sapiens ]
Official Symbol : P4HB
Synonyms : P4HB; prolyl 4-hydroxylase, beta polypeptide; ERBA2L, PO4DB, procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide , procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide (prote
Gene ID : 5034
mRNA Refseq : NM_000918
Protein Refseq : NP_000909
MIM : 176790
Uniprot ID : P07237
Chromosome Location : 17q25
Pathway : Chylomicron-mediated lipid transport, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Lipoprotein metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem;
Function : electron carrier activity; isomerase activity; procollagen-proline 4-dioxygenase activity; protein binding; protein disulfide isomerase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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