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Recombinant Human P4HB Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : P4HB-6656H
Product Overview : P4HB MS Standard C13 and N15-labeled recombinant protein (NP_000909) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 57.1 kDa
AA Sequence : MLRRALLCLAVAALVRADAPEEEDH VLVLRKSNFAEALAAHKYLLVEFYA PWCGHCKALAPEYAKAAGKLKAEGS EIRLAKVDATEESDLAQQYGVRGYP TIKFFRNGDTASPKEYTAGREADDI VNWLKKRTGPAATTLPDGAAAESLV ESSEVAVIGFFKDVESDSAKQFLQA AEAIDDIPFGITSNSDVFSKYQLDK DGVVLFKKFDEGRNNFEGEVTKENL LDFIKHNQLPLVIEFTEQTAPKIFG GEIKTHILLFLPKSVSDYDGKLSNF KTAAESFKGKILFIFIDSDHTDNQR ILEFFGLKKEECPAVRLITLEEEMT KYKPESEELTAERITEFCHRFLEGK IKPHLMSQELPEDWDKQPVKVLVGK NFEDVAFDEKKNVFVEFYAPWCGHC KQLAPIWDKLGETYKDHENIVIAKM DSTANEVEAVKVHSFPTLKFFPASA DRTVIDYNGERTLDGFKKFLESGGQ DGAGDDDDLEDLEEAEEPDMEEDDD QKAVKDELTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : P4HB prolyl 4-hydroxylase subunit beta [ Homo sapiens (human) ]
Official Symbol : P4HB
Synonyms : P4HB; prolyl 4-hydroxylase, beta polypeptide; ERBA2L, PO4DB, procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide, procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide (protein disulfide isomerase associated 1), procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55); protein disulfide-isomerase; collagen prolyl 4 hydroxylase beta; DSI; GIT; P4Hbeta; PDI; PDIA1; PO4HB; PROHB; protein disulfide isomerase family A; member 1; protein disulfide isomerase associated 1; p55; protocollagen hydroxylase; prolyl 4-hydroxylase subunit beta; collagen prolyl 4-hydroxylase beta; thyroid hormone-binding protein p55; glutathione-insulin transhydrogenase; cellular thyroid hormone-binding protein; protein disulfide isomerase-associated 1; protein disulfide isomerase/oxidoreductase; protein disulfide isomerase family A, member 1; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide; PHDB; PO4DB; ERBA2L;
Gene ID : 5034
mRNA Refseq : NM_000918
Protein Refseq : NP_000909
MIM : 176790
UniProt ID : P07237

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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